Biocompatibility of MgF2-coated MgNd2 specimens in contact with mucosa of the nasal sinus: A long term study

Research output: Contribution to journalArticleResearchpeer review

Authors

  • Constantin M. Weber
  • Rainer Eifler
  • Jan Marten Seitz
  • Hans J. Maier
  • Janin Reifenrath
  • Thomas Lenarz
  • Martin Durisin

Research Organisations

External Research Organisations

  • Hannover Medical School (MHH)
  • Michigan Technological University
  • University of Veterinary Medicine of Hannover, Foundation
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Details

Original languageEnglish
Pages (from-to)249-261
Number of pages13
JournalActa biomaterialia
Volume18
Publication statusPublished - 10 Mar 2015

Abstract

Up to now, different surgical techniques and stent systems have already been developed and tested for the continuous and adequate ventilation of the frontal sinuses. However, the results achieved still remain poor. Magnesium-based implants have been successfully used in numerous clinical applications. Offering excellent biocompatibility and biodegradability it may be the ideal material for the development of novel implants of the nasal sinus. Here, we present for the first time results on the behaviour of magnesium alloy in a unique environment, i.e. in contact to the nasal mucosa, air and nasal secretion. In a prospective longitudinal study, magnesium fluoride-coated MgNd2 specimens were implanted in the frontal sinuses of 12 minipigs for the investigation of biocompatibility and of the interface between the implant and the mucosa. Endoscopic examinations, histopathological evaluation and EDX measurements were performed regularly up to 180 days. Endoscopic evaluation showed focal mucosal reaction, however, without affecting the patency of the sinus. In addition, no signs of bacterial infections were observed. The EDX analyses showed a marginal but steady increase in the Mg concentration in the mucosa over 180 days. Histological analysis revealed a locally confined moderate mucosal hyperplasia and unspecific inflammatory reaction. Furthermore, we did not find any osteoinductive effects of the magnesium alloy. The results indicate the excellent biocompatibility of the MgNd2 alloy in contact with nasal mucosa and provide a novel material compound and solid proof-of-principle for the development of magnesium-based nasal stents.

Keywords

    Biocompatibility, ENT surgery, Magnesium, Nasal mucosa

ASJC Scopus subject areas

Cite this

Biocompatibility of MgF2-coated MgNd2 specimens in contact with mucosa of the nasal sinus: A long term study. / Weber, Constantin M.; Eifler, Rainer; Seitz, Jan Marten et al.
In: Acta biomaterialia, Vol. 18, 10.03.2015, p. 249-261.

Research output: Contribution to journalArticleResearchpeer review

Weber CM, Eifler R, Seitz JM, Maier HJ, Reifenrath J, Lenarz T et al. Biocompatibility of MgF2-coated MgNd2 specimens in contact with mucosa of the nasal sinus: A long term study. Acta biomaterialia. 2015 Mar 10;18:249-261. doi: 10.1016/j.actbio.2015.03.003
Weber, Constantin M. ; Eifler, Rainer ; Seitz, Jan Marten et al. / Biocompatibility of MgF2-coated MgNd2 specimens in contact with mucosa of the nasal sinus : A long term study. In: Acta biomaterialia. 2015 ; Vol. 18. pp. 249-261.
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abstract = "Up to now, different surgical techniques and stent systems have already been developed and tested for the continuous and adequate ventilation of the frontal sinuses. However, the results achieved still remain poor. Magnesium-based implants have been successfully used in numerous clinical applications. Offering excellent biocompatibility and biodegradability it may be the ideal material for the development of novel implants of the nasal sinus. Here, we present for the first time results on the behaviour of magnesium alloy in a unique environment, i.e. in contact to the nasal mucosa, air and nasal secretion. In a prospective longitudinal study, magnesium fluoride-coated MgNd2 specimens were implanted in the frontal sinuses of 12 minipigs for the investigation of biocompatibility and of the interface between the implant and the mucosa. Endoscopic examinations, histopathological evaluation and EDX measurements were performed regularly up to 180 days. Endoscopic evaluation showed focal mucosal reaction, however, without affecting the patency of the sinus. In addition, no signs of bacterial infections were observed. The EDX analyses showed a marginal but steady increase in the Mg concentration in the mucosa over 180 days. Histological analysis revealed a locally confined moderate mucosal hyperplasia and unspecific inflammatory reaction. Furthermore, we did not find any osteoinductive effects of the magnesium alloy. The results indicate the excellent biocompatibility of the MgNd2 alloy in contact with nasal mucosa and provide a novel material compound and solid proof-of-principle for the development of magnesium-based nasal stents.",
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note = "Funding Information: The project is funded by the German Research Foundation (Collaborative Research Center SFB 599 Project R1). We thank especially Tanja Meyer (MedImplant GmbH, Hannover, Germany) for excellent collaboration. We are very grateful with Nickolas Fedchenko (University of Veterinary Medicine, Foundation, Hannover, Germany) for support in histological preparation. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",
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T1 - Biocompatibility of MgF2-coated MgNd2 specimens in contact with mucosa of the nasal sinus

T2 - A long term study

AU - Weber, Constantin M.

AU - Eifler, Rainer

AU - Seitz, Jan Marten

AU - Maier, Hans J.

AU - Reifenrath, Janin

AU - Lenarz, Thomas

AU - Durisin, Martin

N1 - Funding Information: The project is funded by the German Research Foundation (Collaborative Research Center SFB 599 Project R1). We thank especially Tanja Meyer (MedImplant GmbH, Hannover, Germany) for excellent collaboration. We are very grateful with Nickolas Fedchenko (University of Veterinary Medicine, Foundation, Hannover, Germany) for support in histological preparation. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2015/3/10

Y1 - 2015/3/10

N2 - Up to now, different surgical techniques and stent systems have already been developed and tested for the continuous and adequate ventilation of the frontal sinuses. However, the results achieved still remain poor. Magnesium-based implants have been successfully used in numerous clinical applications. Offering excellent biocompatibility and biodegradability it may be the ideal material for the development of novel implants of the nasal sinus. Here, we present for the first time results on the behaviour of magnesium alloy in a unique environment, i.e. in contact to the nasal mucosa, air and nasal secretion. In a prospective longitudinal study, magnesium fluoride-coated MgNd2 specimens were implanted in the frontal sinuses of 12 minipigs for the investigation of biocompatibility and of the interface between the implant and the mucosa. Endoscopic examinations, histopathological evaluation and EDX measurements were performed regularly up to 180 days. Endoscopic evaluation showed focal mucosal reaction, however, without affecting the patency of the sinus. In addition, no signs of bacterial infections were observed. The EDX analyses showed a marginal but steady increase in the Mg concentration in the mucosa over 180 days. Histological analysis revealed a locally confined moderate mucosal hyperplasia and unspecific inflammatory reaction. Furthermore, we did not find any osteoinductive effects of the magnesium alloy. The results indicate the excellent biocompatibility of the MgNd2 alloy in contact with nasal mucosa and provide a novel material compound and solid proof-of-principle for the development of magnesium-based nasal stents.

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KW - Biocompatibility

KW - ENT surgery

KW - Magnesium

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ER -

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