Details
| Original language | English |
|---|---|
| Article number | 84 |
| Journal | CATALYSTS |
| Volume | 14 |
| Issue number | 1 |
| Publication status | Published - 19 Jan 2024 |
Abstract
Biocatalysis holds immense potential for pharmaceutical development as it enables synthetic routes to various chiral building blocks with unparalleled selectivity. Therein, solvent and water use account for a large contribution to the environmental impact of the reactions. In the spirit of Green Chemistry, a transition from traditional highly diluted aqueous systems to intensified non-aqueous media to overcome limitations (e.g., water shortages, recalcitrant wastewater treatments, and low substrate loadings) has been observed. Benefiting from the spectacular advances in various enzyme stabilization techniques, a plethora of biotransformations in non-conventional media have been established. Deep eutectic solvents (DESs) emerge as a sort of (potentially) greener non-aqueous medium with increasing use in biocatalysis. This review discusses the state-of-the-art of biotransformations in DESs with a focus on biocatalytic pathways for the synthesis of active pharmaceutical ingredients (APIs). Representative examples of different enzyme classes are discussed, together with a critical vision of the limitations and discussing prospects of using DESs for biocatalysis.
Keywords
- active pharmaceutical active ingredients, biocatalysis, deep eutectic solvents, enzymes, green chemistry
ASJC Scopus subject areas
- Environmental Science(all)
- Chemical Engineering(all)
- Catalysis
- Chemistry(all)
- Physical and Theoretical Chemistry
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In: CATALYSTS, Vol. 14, No. 1, 84, 19.01.2024.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Biocatalysis for the Synthesis of Active Pharmaceutical Ingredients in Deep Eutectic Solvents: State-of-the-Art and Prospects
AU - Zhang, Ningning
AU - María, Pablo Domínguez de
AU - Kara, Selin
N1 - This project has received funding from the EU’s Horizon Europe Doctoral Network Program under the Marie Skłodowska-Curie grant agreement no. 101072731. The authors acknowledge the financial support from Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under grant no. 391127961.
PY - 2024/1/19
Y1 - 2024/1/19
N2 - Biocatalysis holds immense potential for pharmaceutical development as it enables synthetic routes to various chiral building blocks with unparalleled selectivity. Therein, solvent and water use account for a large contribution to the environmental impact of the reactions. In the spirit of Green Chemistry, a transition from traditional highly diluted aqueous systems to intensified non-aqueous media to overcome limitations (e.g., water shortages, recalcitrant wastewater treatments, and low substrate loadings) has been observed. Benefiting from the spectacular advances in various enzyme stabilization techniques, a plethora of biotransformations in non-conventional media have been established. Deep eutectic solvents (DESs) emerge as a sort of (potentially) greener non-aqueous medium with increasing use in biocatalysis. This review discusses the state-of-the-art of biotransformations in DESs with a focus on biocatalytic pathways for the synthesis of active pharmaceutical ingredients (APIs). Representative examples of different enzyme classes are discussed, together with a critical vision of the limitations and discussing prospects of using DESs for biocatalysis.
AB - Biocatalysis holds immense potential for pharmaceutical development as it enables synthetic routes to various chiral building blocks with unparalleled selectivity. Therein, solvent and water use account for a large contribution to the environmental impact of the reactions. In the spirit of Green Chemistry, a transition from traditional highly diluted aqueous systems to intensified non-aqueous media to overcome limitations (e.g., water shortages, recalcitrant wastewater treatments, and low substrate loadings) has been observed. Benefiting from the spectacular advances in various enzyme stabilization techniques, a plethora of biotransformations in non-conventional media have been established. Deep eutectic solvents (DESs) emerge as a sort of (potentially) greener non-aqueous medium with increasing use in biocatalysis. This review discusses the state-of-the-art of biotransformations in DESs with a focus on biocatalytic pathways for the synthesis of active pharmaceutical ingredients (APIs). Representative examples of different enzyme classes are discussed, together with a critical vision of the limitations and discussing prospects of using DESs for biocatalysis.
KW - active pharmaceutical active ingredients
KW - biocatalysis
KW - deep eutectic solvents
KW - enzymes
KW - green chemistry
UR - http://www.scopus.com/inward/record.url?scp=85183395247&partnerID=8YFLogxK
U2 - 10.3390/catal14010084
DO - 10.3390/catal14010084
M3 - Article
VL - 14
JO - CATALYSTS
JF - CATALYSTS
SN - 2073-4344
IS - 1
M1 - 84
ER -