Details
| Original language | English |
|---|---|
| Title of host publication | 2022 IEEE Biomedical Circuits and Systems Conference (BioCAS) |
| Pages | 297-301 |
| Number of pages | 5 |
| ISBN (electronic) | 978-1-6654-6917-3 |
| Publication status | Published - 2022 |
Abstract
To support vascular tissue generation and maturation in vitro, a suitable environment providing dynamic cultivation is essential and can be achieved within specialized bioreactor systems. This paper describes the implementation and evaluation of a fluid circuit for automatically controlled flow and pressure conditions in medium to large vascular grafts with an inner diameter of up to 8 mm. Shear stresses exerted on the cultivating vascular graft's inner wall and fluid flow patterns were computed using Computational Fluid Dynamic simulations. Adjustment of the nutrient medium's viscosity ensures laminar flow and reduces the required flow rate for shear stresses of at least 20 dyn/cm2. A custom pressure sensor suited for steam sterilization with an accuracy of 0.1 mmHg was developed and optimized with regard to its impact on the laminar velocity profile. The presented system provides comprehensive conditioning for the cultivation of medium to large vessels to meet the clinical needs of viable tissue grafts but also for physiological research applications.
Keywords
- Bioreactor, Dynamic Cultivation, Large Vascular Graft, Pressure Sensor, Tissue Engineering
ASJC Scopus subject areas
- Computer Science(all)
- Artificial Intelligence
- Computer Science(all)
- Signal Processing
- Engineering(all)
- Biomedical Engineering
- Engineering(all)
- Electrical and Electronic Engineering
- Neuroscience(all)
- Neuroscience (miscellaneous)
- Physics and Astronomy(all)
- Instrumentation
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2022 IEEE Biomedical Circuits and Systems Conference (BioCAS). 2022. p. 297-301.
Research output: Chapter in book/report/conference proceeding › Conference contribution › Research › peer review
}
TY - GEN
T1 - Automatically Controlled Flow and Pressure Conditions in a Bioreactor System for Medium- to Large-Sized Tissue-Engineered Vascular Grafts
AU - Stanislawski, Nils
AU - Lindwedel, Noah
AU - Blume, Cornelia
AU - Blume, Holger
N1 - Funding Information: ACKNOWLEDGMENT This work was financially supported by the Ministry of Economy and Culture (MWK) of Lower Saxony, Germany, as part of the SMART BIOTECS initiative.
PY - 2022
Y1 - 2022
N2 - To support vascular tissue generation and maturation in vitro, a suitable environment providing dynamic cultivation is essential and can be achieved within specialized bioreactor systems. This paper describes the implementation and evaluation of a fluid circuit for automatically controlled flow and pressure conditions in medium to large vascular grafts with an inner diameter of up to 8 mm. Shear stresses exerted on the cultivating vascular graft's inner wall and fluid flow patterns were computed using Computational Fluid Dynamic simulations. Adjustment of the nutrient medium's viscosity ensures laminar flow and reduces the required flow rate for shear stresses of at least 20 dyn/cm2. A custom pressure sensor suited for steam sterilization with an accuracy of 0.1 mmHg was developed and optimized with regard to its impact on the laminar velocity profile. The presented system provides comprehensive conditioning for the cultivation of medium to large vessels to meet the clinical needs of viable tissue grafts but also for physiological research applications.
AB - To support vascular tissue generation and maturation in vitro, a suitable environment providing dynamic cultivation is essential and can be achieved within specialized bioreactor systems. This paper describes the implementation and evaluation of a fluid circuit for automatically controlled flow and pressure conditions in medium to large vascular grafts with an inner diameter of up to 8 mm. Shear stresses exerted on the cultivating vascular graft's inner wall and fluid flow patterns were computed using Computational Fluid Dynamic simulations. Adjustment of the nutrient medium's viscosity ensures laminar flow and reduces the required flow rate for shear stresses of at least 20 dyn/cm2. A custom pressure sensor suited for steam sterilization with an accuracy of 0.1 mmHg was developed and optimized with regard to its impact on the laminar velocity profile. The presented system provides comprehensive conditioning for the cultivation of medium to large vessels to meet the clinical needs of viable tissue grafts but also for physiological research applications.
KW - Bioreactor
KW - Dynamic Cultivation
KW - Large Vascular Graft
KW - Pressure Sensor
KW - Tissue Engineering
UR - http://www.scopus.com/inward/record.url?scp=85142921652&partnerID=8YFLogxK
U2 - 10.1109/biocas54905.2022.9948544
DO - 10.1109/biocas54905.2022.9948544
M3 - Conference contribution
SN - 978-1-6654-6918-0
SP - 297
EP - 301
BT - 2022 IEEE Biomedical Circuits and Systems Conference (BioCAS)
ER -