Details
| Original language | English |
|---|---|
| Pages (from-to) | 69-74 |
| Number of pages | 6 |
| Journal | Sensors and Actuators, A: Physical |
| Volume | 198 |
| Early online date | 2 May 2013 |
| Publication status | Published - 15 Aug 2013 |
Abstract
Many applications of sonic velocity measurements for material testing are known and widely employed. Yet the technique is rarely employed in biotechnology especially for process monitoring. The ultrasonic resonator technology allows a highly precise measurement of the sonic velocity in small volumes, which makes this technology interesting for process analytics. New techniques give information about various process parameters on-line and in real time. Nowadays special interest is the on-line product analytic. Not only is the product concentration is in focus, but the purity and activity, which are currently rarely accessible on-line. The ultrasonic resonator is an opportunity to close this gap. An evaluation method will be introduced to ensure a maximum in precision and accuracy during the measurement. The best obtained precision of less than 0.3 mm s-1 sonic velocity and an accuracy of 0.027 m s -1, for water at different temperatures, give the possibility to detect slightest changes and recover worthwhile information during the measurements.
Keywords
- On-line process monitoring, Protein detection, Protein folding, Sonic velocity evaluation, Ultrasonic resonator
ASJC Scopus subject areas
- Materials Science(all)
- Electronic, Optical and Magnetic Materials
- Physics and Astronomy(all)
- Instrumentation
- Physics and Astronomy(all)
- Condensed Matter Physics
- Materials Science(all)
- Surfaces, Coatings and Films
- Materials Science(all)
- Metals and Alloys
- Engineering(all)
- Electrical and Electronic Engineering
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In: Sensors and Actuators, A: Physical, Vol. 198, 15.08.2013, p. 69-74.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Automated sonic velocity calculation based on ultrasonic resonator measurements for on-line process monitoring
AU - Stanke, Marc
AU - Lindner, Patrick
AU - Holz, Stephanie
AU - Hitzmann, Bernd
PY - 2013/8/15
Y1 - 2013/8/15
N2 - Many applications of sonic velocity measurements for material testing are known and widely employed. Yet the technique is rarely employed in biotechnology especially for process monitoring. The ultrasonic resonator technology allows a highly precise measurement of the sonic velocity in small volumes, which makes this technology interesting for process analytics. New techniques give information about various process parameters on-line and in real time. Nowadays special interest is the on-line product analytic. Not only is the product concentration is in focus, but the purity and activity, which are currently rarely accessible on-line. The ultrasonic resonator is an opportunity to close this gap. An evaluation method will be introduced to ensure a maximum in precision and accuracy during the measurement. The best obtained precision of less than 0.3 mm s-1 sonic velocity and an accuracy of 0.027 m s -1, for water at different temperatures, give the possibility to detect slightest changes and recover worthwhile information during the measurements.
AB - Many applications of sonic velocity measurements for material testing are known and widely employed. Yet the technique is rarely employed in biotechnology especially for process monitoring. The ultrasonic resonator technology allows a highly precise measurement of the sonic velocity in small volumes, which makes this technology interesting for process analytics. New techniques give information about various process parameters on-line and in real time. Nowadays special interest is the on-line product analytic. Not only is the product concentration is in focus, but the purity and activity, which are currently rarely accessible on-line. The ultrasonic resonator is an opportunity to close this gap. An evaluation method will be introduced to ensure a maximum in precision and accuracy during the measurement. The best obtained precision of less than 0.3 mm s-1 sonic velocity and an accuracy of 0.027 m s -1, for water at different temperatures, give the possibility to detect slightest changes and recover worthwhile information during the measurements.
KW - On-line process monitoring
KW - Protein detection
KW - Protein folding
KW - Sonic velocity evaluation
KW - Ultrasonic resonator
UR - http://www.scopus.com/inward/record.url?scp=84877976666&partnerID=8YFLogxK
U2 - 10.1016/j.sna.2013.03.024
DO - 10.1016/j.sna.2013.03.024
M3 - Article
AN - SCOPUS:84877976666
VL - 198
SP - 69
EP - 74
JO - Sensors and Actuators, A: Physical
JF - Sensors and Actuators, A: Physical
SN - 0924-4247
ER -