Details
| Original language | English |
|---|---|
| Article number | 133 |
| Journal | Nutrients |
| Volume | 10 |
| Issue number | 2 |
| Early online date | 27 Jan 2018 |
| Publication status | Published - Feb 2018 |
| Externally published | Yes |
Abstract
In addition to well-established risk factors like older age, female gender, and adiposity, oxidative stress may play a role in the pathophysiology of gallstone disease. Since vitamin E exerts important anti-oxidative functions, we hypothesized that circulating vitamin E levels might be inversely associated with prevalence of gallstone disease. In a cross-sectional study, we measured plasma levels of α- and γ-tocopherol using high performance liquid chromatography in a community-based sample (582 individuals; median age 62 years; 38.5% women). Gallstone disease status was assessed by ultrasound. Multivariable-adjusted logistic regression models were used to estimate the association of circulating α- and γ-tocopherol/cholesterol ratio levels with prevalent gallstone disease. Lower probabilities of having gallstone disease were observed in the top (compared to the bottom) tertile of the plasma α-tocopherol/cholesterol ratio in multivariable-adjusted models (OR (Odds Ratio): 0.31; 95% CI (Confidence Interval): 0.13-0.76). A lower probability of having gallstone disease was also observed for the γ-tocopherol/cholesterol ratio, though the association did not reach statistical significance (OR: 0.77; 95% CI: 0.35-1.69 for 3rd vs 1st tertile). In conclusion, our observations are consistent with the concept that higher vitamin E levels might protect from gallstone disease, a premise that needs to be further addressed in longitudinal studies.
Keywords
- Gallstone disease, Vitamin E, α-and γ-tocopherol, Body Mass Index, Prevalence, Cross-Sectional Studies, Oxidative Stress, Humans, Middle Aged, Risk Factors, European Continental Ancestry Group, Logistic Models, Male, alpha-Tocopherol/administration & dosage, Exercise, Cholesterol/blood, gamma-Tocopherol/administration & dosage, Biomarkers/blood, Female, Aged, Dietary Supplements, Germany, Gallstones/blood
ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)
- Food Science
- Nursing(all)
- Nutrition and Dietetics
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In: Nutrients, Vol. 10, No. 2, 133, 02.2018.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Association of circulating vitamin E (α- and γ-tocopherol) levels with gallstone disease
AU - Waniek, S.
AU - di Giuseppe, R.
AU - Esatbeyoglu, T.
AU - Ratjen, I.
AU - Enderle, J.
AU - Jacobs, G.
AU - Nöthlings, U.
AU - Koch, M.
AU - Schlesinger, S.
AU - Rimbach, G.
AU - Lieb, W.
N1 - Funding information: Acknowledgments: Romina di Giuseppe is supported by the Deutsche Forschungsgemeinschaft Excellence Cluster “Inflammation at Interfaces” (grants EXC306 and EXC306/2). The PopGen 2.0 Network was supported by the German Federal Ministry of Education and Research (01EY1103). The funding sponsors had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, and in the decision to publish the results.
PY - 2018/2
Y1 - 2018/2
N2 - In addition to well-established risk factors like older age, female gender, and adiposity, oxidative stress may play a role in the pathophysiology of gallstone disease. Since vitamin E exerts important anti-oxidative functions, we hypothesized that circulating vitamin E levels might be inversely associated with prevalence of gallstone disease. In a cross-sectional study, we measured plasma levels of α- and γ-tocopherol using high performance liquid chromatography in a community-based sample (582 individuals; median age 62 years; 38.5% women). Gallstone disease status was assessed by ultrasound. Multivariable-adjusted logistic regression models were used to estimate the association of circulating α- and γ-tocopherol/cholesterol ratio levels with prevalent gallstone disease. Lower probabilities of having gallstone disease were observed in the top (compared to the bottom) tertile of the plasma α-tocopherol/cholesterol ratio in multivariable-adjusted models (OR (Odds Ratio): 0.31; 95% CI (Confidence Interval): 0.13-0.76). A lower probability of having gallstone disease was also observed for the γ-tocopherol/cholesterol ratio, though the association did not reach statistical significance (OR: 0.77; 95% CI: 0.35-1.69 for 3rd vs 1st tertile). In conclusion, our observations are consistent with the concept that higher vitamin E levels might protect from gallstone disease, a premise that needs to be further addressed in longitudinal studies.
AB - In addition to well-established risk factors like older age, female gender, and adiposity, oxidative stress may play a role in the pathophysiology of gallstone disease. Since vitamin E exerts important anti-oxidative functions, we hypothesized that circulating vitamin E levels might be inversely associated with prevalence of gallstone disease. In a cross-sectional study, we measured plasma levels of α- and γ-tocopherol using high performance liquid chromatography in a community-based sample (582 individuals; median age 62 years; 38.5% women). Gallstone disease status was assessed by ultrasound. Multivariable-adjusted logistic regression models were used to estimate the association of circulating α- and γ-tocopherol/cholesterol ratio levels with prevalent gallstone disease. Lower probabilities of having gallstone disease were observed in the top (compared to the bottom) tertile of the plasma α-tocopherol/cholesterol ratio in multivariable-adjusted models (OR (Odds Ratio): 0.31; 95% CI (Confidence Interval): 0.13-0.76). A lower probability of having gallstone disease was also observed for the γ-tocopherol/cholesterol ratio, though the association did not reach statistical significance (OR: 0.77; 95% CI: 0.35-1.69 for 3rd vs 1st tertile). In conclusion, our observations are consistent with the concept that higher vitamin E levels might protect from gallstone disease, a premise that needs to be further addressed in longitudinal studies.
KW - Gallstone disease
KW - Vitamin E
KW - α-and γ-tocopherol
KW - Body Mass Index
KW - Prevalence
KW - Cross-Sectional Studies
KW - Oxidative Stress
KW - Humans
KW - Middle Aged
KW - Risk Factors
KW - European Continental Ancestry Group
KW - Logistic Models
KW - Male
KW - alpha-Tocopherol/administration & dosage
KW - Exercise
KW - Cholesterol/blood
KW - gamma-Tocopherol/administration & dosage
KW - Biomarkers/blood
KW - Female
KW - Aged
KW - Dietary Supplements
KW - Germany
KW - Gallstones/blood
UR - http://www.scopus.com/inward/record.url?scp=85041356479&partnerID=8YFLogxK
U2 - 10.3390/nu10020133
DO - 10.3390/nu10020133
M3 - Article
C2 - 29382041
VL - 10
JO - Nutrients
JF - Nutrients
SN - 2072-6643
IS - 2
M1 - 133
ER -