Details
| Original language | English |
|---|---|
| Pages (from-to) | 976-986 |
| Number of pages | 11 |
| Journal | Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences |
| Volume | 67 |
| Issue number | 10 |
| Publication status | Published - 2 Jun 2014 |
Abstract
Aptamers are single-stranded oligonucleotides composed of RNA or DNA that are able to bind their corresponding targets via molecular recognition. Thus, aptamers can be thought of as nucleic acidbased alternatives to antibodies and have attracted attention as receptors in biosensors. Aptamers seem to be ideal biological recognition elements, since they enable the design of intelligent sensors based on their specific properties. Especially the fact that most aptamers undergo conformational changes during the binding of the target and their oligonucleotide nature can be used to rationally design novel sensing strategies. This review focuses on aptasensors for the detection of small molecules. In the first part, aptamers, their generation and their properties are briefly described. In the second part, different design strategies for aptasensors are reviewed, and examples for the detection of small molecules are given.
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In: Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, Vol. 67, No. 10, 02.06.2014, p. 976-986.
Research output: Contribution to journal › Review article › Research › peer review
}
TY - JOUR
T1 - Aptasensors for Small Molecule Detection
AU - Walter, Johanna Gabriela
AU - Heilkenbrinker, Alexandra
AU - Austerjost, Jonas
AU - Timur, Suna
AU - Stahl, Frank
AU - Scheper, Thomas
N1 - Copyright: Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2014/6/2
Y1 - 2014/6/2
N2 - Aptamers are single-stranded oligonucleotides composed of RNA or DNA that are able to bind their corresponding targets via molecular recognition. Thus, aptamers can be thought of as nucleic acidbased alternatives to antibodies and have attracted attention as receptors in biosensors. Aptamers seem to be ideal biological recognition elements, since they enable the design of intelligent sensors based on their specific properties. Especially the fact that most aptamers undergo conformational changes during the binding of the target and their oligonucleotide nature can be used to rationally design novel sensing strategies. This review focuses on aptasensors for the detection of small molecules. In the first part, aptamers, their generation and their properties are briefly described. In the second part, different design strategies for aptasensors are reviewed, and examples for the detection of small molecules are given.
AB - Aptamers are single-stranded oligonucleotides composed of RNA or DNA that are able to bind their corresponding targets via molecular recognition. Thus, aptamers can be thought of as nucleic acidbased alternatives to antibodies and have attracted attention as receptors in biosensors. Aptamers seem to be ideal biological recognition elements, since they enable the design of intelligent sensors based on their specific properties. Especially the fact that most aptamers undergo conformational changes during the binding of the target and their oligonucleotide nature can be used to rationally design novel sensing strategies. This review focuses on aptasensors for the detection of small molecules. In the first part, aptamers, their generation and their properties are briefly described. In the second part, different design strategies for aptasensors are reviewed, and examples for the detection of small molecules are given.
KW - Aptamer
KW - Aptasensor
KW - Biosensor
KW - Small molecule
UR - http://www.scopus.com/inward/record.url?scp=84867950754&partnerID=8YFLogxK
U2 - 10.5560/ZNB.2012-0147
DO - 10.5560/ZNB.2012-0147
M3 - Review article
AN - SCOPUS:84867950754
VL - 67
SP - 976
EP - 986
JO - Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences
JF - Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences
SN - 0932-0776
IS - 10
ER -