Details
| Original language | English |
|---|---|
| Title of host publication | Aptamers in Biotechnology |
| Pages | 161-193 |
| Number of pages | 33 |
| Volume | 174 |
| Edition | 1 |
| ISBN (electronic) | 978-3-030-54061-6 |
| Publication status | Published - 2020 |
Publication series
| Name | Advances in Biochemical Engineering/Biotechnology |
|---|---|
| Volume | 174 |
| ISSN (Print) | 0724-6145 |
| ISSN (electronic) | 1616-8542 |
Abstract
Since aptamers have been selected against a broad range of target structures of medical interest and nanoparticles are available with diverse properties, aptamer-modified nanoparticles can be used in various diagnostic and therapeutic applications. While the aptamer is responsible for specificity and affinity of the conjugate, the nanoparticles’ function varies from signal generation in diagnostic approaches to drug loading in drug delivery systems. Within this chapter different medical applications of aptamer-modified nanoparticles will be summarized and underlying principles will be described.
Keywords
- Aptamer, Biosensor, Diagnostics, Drug delivery, Nanoparticle, Therapy
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Biotechnology
- Chemical Engineering(all)
- Bioengineering
- Immunology and Microbiology(all)
- Applied Microbiology and Biotechnology
Cite this
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Aptamers in Biotechnology. Vol. 174 1. ed. 2020. p. 161-193 (Advances in Biochemical Engineering/Biotechnology; Vol. 174).
Research output: Chapter in book/report/conference proceeding › Contribution to book/anthology › Research › peer review
}
TY - CHAP
T1 - Aptamer-Modified Nanoparticles in Medical Applications
AU - Eilers, Alina
AU - Witt, Sandra
AU - Walter, Johanna
N1 - Funding Information: This work was funded by the Ministry of Science and Culture of Lower Saxony (MWK Niedersachsen).
PY - 2020
Y1 - 2020
N2 - Since aptamers have been selected against a broad range of target structures of medical interest and nanoparticles are available with diverse properties, aptamer-modified nanoparticles can be used in various diagnostic and therapeutic applications. While the aptamer is responsible for specificity and affinity of the conjugate, the nanoparticles’ function varies from signal generation in diagnostic approaches to drug loading in drug delivery systems. Within this chapter different medical applications of aptamer-modified nanoparticles will be summarized and underlying principles will be described.
AB - Since aptamers have been selected against a broad range of target structures of medical interest and nanoparticles are available with diverse properties, aptamer-modified nanoparticles can be used in various diagnostic and therapeutic applications. While the aptamer is responsible for specificity and affinity of the conjugate, the nanoparticles’ function varies from signal generation in diagnostic approaches to drug loading in drug delivery systems. Within this chapter different medical applications of aptamer-modified nanoparticles will be summarized and underlying principles will be described.
KW - Aptamer
KW - Biosensor
KW - Diagnostics
KW - Drug delivery
KW - Nanoparticle
KW - Therapy
UR - http://www.scopus.com/inward/record.url?scp=85089125585&partnerID=8YFLogxK
U2 - 10.1007/10_2020_124
DO - 10.1007/10_2020_124
M3 - Contribution to book/anthology
C2 - 32157319
AN - SCOPUS:85089125585
SN - 978-3-030-54060-9
SN - 978-3-030-54063-0
VL - 174
T3 - Advances in Biochemical Engineering/Biotechnology
SP - 161
EP - 193
BT - Aptamers in Biotechnology
ER -