Details
| Original language | English |
|---|---|
| Article number | A007 |
| Pages (from-to) | 121-154 |
| Number of pages | 34 |
| Journal | Advances in Biochemical Engineering/Biotechnology |
| Volume | 140 |
| Publication status | Published - 2014 |
Abstract
Aptamers are short oligonucleotides that are capable of selectively binding to their corresponding target. Therefore, they can be thought of as a nucleic acid-based alternative to antibodies and can substitute for their amino acid-based counterparts in analytical applications, including as receptors in biosensors. Here they offer several advantages because their nucleic acid nature and their binding via an induced fit mechanism enable novel sensing strategies. In this article, the utilization of aptamers as novel bio-receptors in combination with nanoparticles as transducer elements is reviewed. In addition to these analytical applications, the medical relevance of aptamer-modified nanoparticles is described.
Keywords
- Adsorption, Aptamers, Nucleotide/chemistry, Biosensing Techniques/methods, Luminescent Measurements/methods, Nanoparticles/chemistry, SELEX Aptamer Technique/methods, Surface Plasmon Resonance/methods, Nanoparticle, Biosensor, Aptamer, Aptasensor
ASJC Scopus subject areas
- Immunology and Microbiology(all)
- Applied Microbiology and Biotechnology
- Chemical Engineering(all)
- Bioengineering
- Biochemistry, Genetics and Molecular Biology(all)
- Biotechnology
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In: Advances in Biochemical Engineering/Biotechnology, Vol. 140, A007, 2014, p. 121-154.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Aptamer-modified nanoparticles as biosensors
AU - Lönne, Maren
AU - Zhu, Guohong
AU - Stahl, Frank
AU - Walter, Johanna-Gabriela
N1 - Publisher Copyright: © Springer-Verlag Berlin Heidelberg 2013. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2014
Y1 - 2014
N2 - Aptamers are short oligonucleotides that are capable of selectively binding to their corresponding target. Therefore, they can be thought of as a nucleic acid-based alternative to antibodies and can substitute for their amino acid-based counterparts in analytical applications, including as receptors in biosensors. Here they offer several advantages because their nucleic acid nature and their binding via an induced fit mechanism enable novel sensing strategies. In this article, the utilization of aptamers as novel bio-receptors in combination with nanoparticles as transducer elements is reviewed. In addition to these analytical applications, the medical relevance of aptamer-modified nanoparticles is described.
AB - Aptamers are short oligonucleotides that are capable of selectively binding to their corresponding target. Therefore, they can be thought of as a nucleic acid-based alternative to antibodies and can substitute for their amino acid-based counterparts in analytical applications, including as receptors in biosensors. Here they offer several advantages because their nucleic acid nature and their binding via an induced fit mechanism enable novel sensing strategies. In this article, the utilization of aptamers as novel bio-receptors in combination with nanoparticles as transducer elements is reviewed. In addition to these analytical applications, the medical relevance of aptamer-modified nanoparticles is described.
KW - Adsorption
KW - Aptamers, Nucleotide/chemistry
KW - Biosensing Techniques/methods
KW - Luminescent Measurements/methods
KW - Nanoparticles/chemistry
KW - SELEX Aptamer Technique/methods
KW - Surface Plasmon Resonance/methods
KW - Nanoparticle
KW - Biosensor
KW - Aptamer
KW - Aptasensor
UR - http://www.scopus.com/inward/record.url?scp=84902651587&partnerID=8YFLogxK
U2 - 10.1007/10_2013_231
DO - 10.1007/10_2013_231
M3 - Article
C2 - 23824145
VL - 140
SP - 121
EP - 154
JO - Advances in Biochemical Engineering/Biotechnology
JF - Advances in Biochemical Engineering/Biotechnology
SN - 0724-6145
M1 - A007
ER -