Details
| Original language | English |
|---|---|
| Pages (from-to) | 4871-4884 |
| Number of pages | 14 |
| Journal | Chemistry - a European journal |
| Volume | 25 |
| Issue number | 19 |
| Publication status | Published - 1 Apr 2019 |
| Externally published | Yes |
Abstract
This Minireview highlights the application of crystallization as a very powerful in situ product removal (ISPR) technique in biocatalytic process design. Special emphasis is placed on its use for in situ product crystallization (ISPC) to overcome unfavorable thermodynamic reaction equilibria, inhibition, and undesired reactions. The combination of these unit operations requires an interdisciplinary perspective to find a holistic solution for the underlying bioprocess intensification approach. Representative examples of successful integrated process options are selected, presented, and assessed regarding their overall productivity and applicability. In addition, parallels to the use of adsorption as a very similar technique are drawn and similarities discussed.
Keywords
- biosynthesis, crystal growth, enzymes, in situ product removal, process intensification
ASJC Scopus subject areas
- Chemical Engineering(all)
- Catalysis
- Chemistry(all)
- Organic Chemistry
Cite this
- Standard
- Harvard
- Apa
- Vancouver
- BibTeX
- RIS
In: Chemistry - a European journal, Vol. 25, No. 19, 01.04.2019, p. 4871-4884.
Research output: Contribution to journal › Review article › Research › peer review
}
TY - JOUR
T1 - Application of In Situ Product Crystallization and Related Techniques in Biocatalytic Processes
AU - Hülsewede, Dennis
AU - Meyer, Lars-Erik
AU - von Langermann, Jan
N1 - Funding information: We thank Prof. Udo Kragl (University of Rostock, Germany), Prof. Uwe Bornscheuer (University of Greifswald, Germany), and Prof. Andreas Seidel-Morgenstern (Otto von Guericke University Magdeburg, Germany) for their ongoing support and useful discussions. Funding for D.H. by the DFG (Deutsche Forschungsgemeinschaft, grant number LA 4183/1-1), for L.E.M. by the DFG (grant number KR 2491/11-1), and for J.v.L. by the BMBF (Bundesministerium für Bildung und Forschung; grant number: 031A123) is gratefully acknowledged. This research project is cofunded by the Leibniz Science Campus Phosphorus Research Rostock. We also thank Johanna Claus for her creative assistance with the TOC figure. We thank Prof. Udo Kragl (University of Rostock, Germany), Prof. Uwe Bornscheuer (University of Greifswald, Germany), and Prof. Andreas Seidel-Morgenstern (Otto von Guericke University Magdeburg, Germany) for their ongoing support and useful discussions. Funding for D.H. by the DFG (Deutsche For-schungsgemeinschaft, grant number LA 4183/1-1), for L.E.M. by the DFG (grant number KR 2491/11-1), and for J.v.L. by the BMBF (Bundesministerium für Bildung und Forschung; grant number: 031A123) is gratefully acknowledged. This research project is cofunded by the Leibniz Science Campus Phosphorus Research Rostock. We also thank Johanna Claus for her creative assistance with the TOC figure.
PY - 2019/4/1
Y1 - 2019/4/1
N2 - This Minireview highlights the application of crystallization as a very powerful in situ product removal (ISPR) technique in biocatalytic process design. Special emphasis is placed on its use for in situ product crystallization (ISPC) to overcome unfavorable thermodynamic reaction equilibria, inhibition, and undesired reactions. The combination of these unit operations requires an interdisciplinary perspective to find a holistic solution for the underlying bioprocess intensification approach. Representative examples of successful integrated process options are selected, presented, and assessed regarding their overall productivity and applicability. In addition, parallels to the use of adsorption as a very similar technique are drawn and similarities discussed.
AB - This Minireview highlights the application of crystallization as a very powerful in situ product removal (ISPR) technique in biocatalytic process design. Special emphasis is placed on its use for in situ product crystallization (ISPC) to overcome unfavorable thermodynamic reaction equilibria, inhibition, and undesired reactions. The combination of these unit operations requires an interdisciplinary perspective to find a holistic solution for the underlying bioprocess intensification approach. Representative examples of successful integrated process options are selected, presented, and assessed regarding their overall productivity and applicability. In addition, parallels to the use of adsorption as a very similar technique are drawn and similarities discussed.
KW - biosynthesis
KW - crystal growth
KW - enzymes
KW - in situ product removal
KW - process intensification
UR - http://www.scopus.com/inward/record.url?scp=85060568205&partnerID=8YFLogxK
U2 - 10.1002/chem.201804970
DO - 10.1002/chem.201804970
M3 - Review article
C2 - 30395380
AN - SCOPUS:85060568205
VL - 25
SP - 4871
EP - 4884
JO - Chemistry - a European journal
JF - Chemistry - a European journal
SN - 0947-6539
IS - 19
ER -