Details
| Original language | English |
|---|---|
| Pages (from-to) | 104-107 |
| Journal | Biomedizinische Technik |
| Volume | 59 |
| Publication status | Published - 2014 |
Abstract
Piezoelectric polymers have often been studied as films and bulk materials in various medical applications, nevertheless publications of investigations of piezoelectric fiber structures are still limited. In neural tissue engineering some piezoelectric polymers are being investigated as potential scaffolds for supporting the nerve regeneration processes. A promising material is polyvinylidine fluoride (PVDF) because of its proven biocompatibility and piezoelectric properties, which can possibly stimulate the cells ingrowth with its electrical activity when it is mechanically deformed. In a study to prove its suitability to regenerative medicine, PVDF was electrospun into fibrous scaffolds by testing different concentrations (20- 30 wt.%) of PVDF dissolved in N,N-dimethylformamide (DMF) and acetone (6:4 and 8:2). For the electrospinning process different flow rates (0.3-2 ml/h) and voltages (16-28 kV) were used to produce defined fibrous scaffolds. The structures of the electrospun PVDF scaffolds were observed and analysed with a scanning electron microscope (SEM) and then evaluated for its mechanical properties, biocompatibility and piezoelectric effect. Electrospun PVDF was compared to untreated/raw PVDF pellets with respect to the presence of the nonpolar α-phase and piezoelectric β-phase by using Fourier-transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC). The growing of mouse embryonic fibroblasts cells (3T3) was evaluated on electrospun PVDF scaffolds. Electrospun scaffolds with a concentration of 30 wt.% PVDF resulted in the formation of the piezoelectric β-phase with the highest β-phase ratio. 3T3 cells cultured on the scaffolds were well attached as indicated by spread morphology. The results demonstrate the potential for the use of PVDF scaffolds for tissue engineering applications.
ASJC Scopus subject areas
- Engineering(all)
- Biomedical Engineering
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In: Biomedizinische Technik, Vol. 59, 2014, p. 104-107.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Application of electrospun piezoelectric PVDF-scaffolds for nerve regeneration
AU - Al Halabi, Fedaa
AU - Behrens, Peter
AU - Glasmacher, Birgit
PY - 2014
Y1 - 2014
N2 - Piezoelectric polymers have often been studied as films and bulk materials in various medical applications, nevertheless publications of investigations of piezoelectric fiber structures are still limited. In neural tissue engineering some piezoelectric polymers are being investigated as potential scaffolds for supporting the nerve regeneration processes. A promising material is polyvinylidine fluoride (PVDF) because of its proven biocompatibility and piezoelectric properties, which can possibly stimulate the cells ingrowth with its electrical activity when it is mechanically deformed. In a study to prove its suitability to regenerative medicine, PVDF was electrospun into fibrous scaffolds by testing different concentrations (20- 30 wt.%) of PVDF dissolved in N,N-dimethylformamide (DMF) and acetone (6:4 and 8:2). For the electrospinning process different flow rates (0.3-2 ml/h) and voltages (16-28 kV) were used to produce defined fibrous scaffolds. The structures of the electrospun PVDF scaffolds were observed and analysed with a scanning electron microscope (SEM) and then evaluated for its mechanical properties, biocompatibility and piezoelectric effect. Electrospun PVDF was compared to untreated/raw PVDF pellets with respect to the presence of the nonpolar α-phase and piezoelectric β-phase by using Fourier-transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC). The growing of mouse embryonic fibroblasts cells (3T3) was evaluated on electrospun PVDF scaffolds. Electrospun scaffolds with a concentration of 30 wt.% PVDF resulted in the formation of the piezoelectric β-phase with the highest β-phase ratio. 3T3 cells cultured on the scaffolds were well attached as indicated by spread morphology. The results demonstrate the potential for the use of PVDF scaffolds for tissue engineering applications.
AB - Piezoelectric polymers have often been studied as films and bulk materials in various medical applications, nevertheless publications of investigations of piezoelectric fiber structures are still limited. In neural tissue engineering some piezoelectric polymers are being investigated as potential scaffolds for supporting the nerve regeneration processes. A promising material is polyvinylidine fluoride (PVDF) because of its proven biocompatibility and piezoelectric properties, which can possibly stimulate the cells ingrowth with its electrical activity when it is mechanically deformed. In a study to prove its suitability to regenerative medicine, PVDF was electrospun into fibrous scaffolds by testing different concentrations (20- 30 wt.%) of PVDF dissolved in N,N-dimethylformamide (DMF) and acetone (6:4 and 8:2). For the electrospinning process different flow rates (0.3-2 ml/h) and voltages (16-28 kV) were used to produce defined fibrous scaffolds. The structures of the electrospun PVDF scaffolds were observed and analysed with a scanning electron microscope (SEM) and then evaluated for its mechanical properties, biocompatibility and piezoelectric effect. Electrospun PVDF was compared to untreated/raw PVDF pellets with respect to the presence of the nonpolar α-phase and piezoelectric β-phase by using Fourier-transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC). The growing of mouse embryonic fibroblasts cells (3T3) was evaluated on electrospun PVDF scaffolds. Electrospun scaffolds with a concentration of 30 wt.% PVDF resulted in the formation of the piezoelectric β-phase with the highest β-phase ratio. 3T3 cells cultured on the scaffolds were well attached as indicated by spread morphology. The results demonstrate the potential for the use of PVDF scaffolds for tissue engineering applications.
UR - http://www.scopus.com/inward/record.url?scp=84908161202&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:84908161202
VL - 59
SP - 104
EP - 107
JO - Biomedizinische Technik
JF - Biomedizinische Technik
SN - 0013-5585
ER -