Details
| Original language | English |
|---|---|
| Pages (from-to) | 3756-3763 |
| Number of pages | 8 |
| Journal | Analytical chemistry |
| Volume | 82 |
| Issue number | 9 |
| Publication status | Published - 30 Mar 2010 |
Abstract
Ion mobility spectrometry (IMS) is a well-known method for detecting hazardous compounds in air. Typical applications are the detection of chemical warfare agents, highly toxic industrial compounds, explosives, and drugs of abuse. Detection limits in the low part per billion range, fast response times, and simple instrumentation make this technique more and more popular. Common ion mobility spectrometers work by employing a radioactive source to provide electrons with high energy to ionize analytes in a series of chemical reactions. General security as well as regulatory concerns related to radioactivity result in the need for a different ionization source which on the other hand produces ions in a similar manner as a radioactive source since the ion chemistry is well-known. Here we show the application of a novel nonradioactive source that produces spectra similar to those obtained with radioactive tritium sources. Using this source in a pulsed mode offers the additional advantage of selecting certain analytes by their recombination time and thus significantly increasing the selectivity. The successful isolation of a target signal in the presence of contaminants using a pulsed electron beam or more precisely the difference in recombination times will be demonstrated for the case of dimethyl- methylphosphonate (DMMP) showing the potential of this source to reduce the possibility for false-positive detection of corresponding chemical warfare agents (CWA) by IMS.
ASJC Scopus subject areas
- Chemistry(all)
- Analytical Chemistry
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In: Analytical chemistry, Vol. 82, No. 9, 30.03.2010, p. 3756-3763.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Application of a Nonradioactive Pulsed Electron Source for Ion Mobility Spectrometry
AU - Gunzer, Frank
AU - Zimmermann, Stefan
AU - Baether, Wolfgang
PY - 2010/3/30
Y1 - 2010/3/30
N2 - Ion mobility spectrometry (IMS) is a well-known method for detecting hazardous compounds in air. Typical applications are the detection of chemical warfare agents, highly toxic industrial compounds, explosives, and drugs of abuse. Detection limits in the low part per billion range, fast response times, and simple instrumentation make this technique more and more popular. Common ion mobility spectrometers work by employing a radioactive source to provide electrons with high energy to ionize analytes in a series of chemical reactions. General security as well as regulatory concerns related to radioactivity result in the need for a different ionization source which on the other hand produces ions in a similar manner as a radioactive source since the ion chemistry is well-known. Here we show the application of a novel nonradioactive source that produces spectra similar to those obtained with radioactive tritium sources. Using this source in a pulsed mode offers the additional advantage of selecting certain analytes by their recombination time and thus significantly increasing the selectivity. The successful isolation of a target signal in the presence of contaminants using a pulsed electron beam or more precisely the difference in recombination times will be demonstrated for the case of dimethyl- methylphosphonate (DMMP) showing the potential of this source to reduce the possibility for false-positive detection of corresponding chemical warfare agents (CWA) by IMS.
AB - Ion mobility spectrometry (IMS) is a well-known method for detecting hazardous compounds in air. Typical applications are the detection of chemical warfare agents, highly toxic industrial compounds, explosives, and drugs of abuse. Detection limits in the low part per billion range, fast response times, and simple instrumentation make this technique more and more popular. Common ion mobility spectrometers work by employing a radioactive source to provide electrons with high energy to ionize analytes in a series of chemical reactions. General security as well as regulatory concerns related to radioactivity result in the need for a different ionization source which on the other hand produces ions in a similar manner as a radioactive source since the ion chemistry is well-known. Here we show the application of a novel nonradioactive source that produces spectra similar to those obtained with radioactive tritium sources. Using this source in a pulsed mode offers the additional advantage of selecting certain analytes by their recombination time and thus significantly increasing the selectivity. The successful isolation of a target signal in the presence of contaminants using a pulsed electron beam or more precisely the difference in recombination times will be demonstrated for the case of dimethyl- methylphosphonate (DMMP) showing the potential of this source to reduce the possibility for false-positive detection of corresponding chemical warfare agents (CWA) by IMS.
UR - http://www.scopus.com/inward/record.url?scp=77951867484&partnerID=8YFLogxK
U2 - 10.1021/ac100166m
DO - 10.1021/ac100166m
M3 - Article
AN - SCOPUS:77951867484
VL - 82
SP - 3756
EP - 3763
JO - Analytical chemistry
JF - Analytical chemistry
SN - 0003-2700
IS - 9
ER -