Details
| Original language | English |
|---|---|
| Pages (from-to) | 7278-7283 |
| Number of pages | 6 |
| Journal | Organic and Biomolecular Chemistry |
| Volume | 20 |
| Issue number | 36 |
| Publication status | Published - 26 Aug 2022 |
Abstract
Antroxazole A (1), a chamigrane type sesquiterpene dimer containing an oxazole moiety, has been characterized from cultures of the fungus Antrodiella albocinnamomea. The structure with absolute configuration was determined by extensive spectroscopic methods and single crystal X-ray diffraction. A plausible biosynthetic pathway for 1 was proposed. Compound 1 exhibits inhibition specifically against the LPS-induced proliferation of B lymphocyte cells with an IC50 value of 16.3 μM.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Chemistry(all)
- Physical and Theoretical Chemistry
- Chemistry(all)
- Organic Chemistry
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In: Organic and Biomolecular Chemistry, Vol. 20, No. 36, 26.08.2022, p. 7278-7283.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Antroxazole A, an oxazole-containing chamigrane dimer from the fungus Antrodiella albocinnamomea with immunosuppressive activity
AU - He, Juan
AU - Yu, Wei Wei
AU - Isaka, Masahiko
AU - Cox, Russell J.
AU - Liu, Ji Kai
AU - Feng, Tao
N1 - Funding Information: The work is financially supported by the National Natural Science Foundation of China (81872762, 22177139, 21961142008), the Fundamental Research Funds for the Central Universities, South-Central Minzu University (CZP21001), and the Thailand Research Fund (DBG6280008).
PY - 2022/8/26
Y1 - 2022/8/26
N2 - Antroxazole A (1), a chamigrane type sesquiterpene dimer containing an oxazole moiety, has been characterized from cultures of the fungus Antrodiella albocinnamomea. The structure with absolute configuration was determined by extensive spectroscopic methods and single crystal X-ray diffraction. A plausible biosynthetic pathway for 1 was proposed. Compound 1 exhibits inhibition specifically against the LPS-induced proliferation of B lymphocyte cells with an IC50 value of 16.3 μM.
AB - Antroxazole A (1), a chamigrane type sesquiterpene dimer containing an oxazole moiety, has been characterized from cultures of the fungus Antrodiella albocinnamomea. The structure with absolute configuration was determined by extensive spectroscopic methods and single crystal X-ray diffraction. A plausible biosynthetic pathway for 1 was proposed. Compound 1 exhibits inhibition specifically against the LPS-induced proliferation of B lymphocyte cells with an IC50 value of 16.3 μM.
UR - http://www.scopus.com/inward/record.url?scp=85138460529&partnerID=8YFLogxK
U2 - 10.1039/d2ob01443b
DO - 10.1039/d2ob01443b
M3 - Article
C2 - 36043515
AN - SCOPUS:85138460529
VL - 20
SP - 7278
EP - 7283
JO - Organic and Biomolecular Chemistry
JF - Organic and Biomolecular Chemistry
SN - 1477-0520
IS - 36
ER -