Details
| Original language | English |
|---|---|
| Pages (from-to) | W46-W50 |
| Journal | Nucleic acids research |
| Volume | 51 |
| Issue number | W1 |
| Early online date | 4 May 2023 |
| Publication status | Published - 5 Jul 2023 |
Abstract
Microorganisms produce small bioactive compounds as part of their secondary or specialised metabolism. Often, such metabolites have antimicrobial, anticancer, antifungal, antiviral or other bio-Activities and thus play an important role for applications in medicine and agriculture. In the past decade, genome mining has become a widely-used method to explore, access, and analyse the available biodiversity of these compounds. Since 2011, the 'antibiotics and secondary metabolite analysis shell-antiSMASH' (https://antismash.secondarymetabolites.org/) has supported researchers in their microbial genome mining tasks, both as a free to use web server and as a standalone tool under an OSI-Approved open source licence. It is currently the most widely used tool for detecting and characterising biosynthetic gene clusters (BGCs) in archaea, bacteria, and fungi. Here, we present the updated version 7 of antiSMASH. antiSMASH 7 increases the number of supported cluster types from 71 to 81, as well as containing improvements in the areas of chemical structure prediction, enzymatic assembly-line visualisation and gene cluster regulation.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Genetics
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In: Nucleic acids research, Vol. 51, No. W1, 05.07.2023, p. W46-W50.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - AntiSMASH 7.0
T2 - new and improved predictions for detection, regulation, chemical structures and visualisation
AU - Blin, Kai
AU - Shaw, Simon
AU - Augustijn, Hannah E.
AU - Reitz, Zachary L.
AU - Biermann, Friederike
AU - Alanjary, Mohammad
AU - Fetter, Artem
AU - Terlouw, Barbara R.
AU - Metcalf, William W.
AU - Helfrich, Eric J.N.
AU - Van Wezel, Gilles P.
AU - Medema, Marnix H.
AU - Weber, Tilmann
N1 - Funding Information: Novo Nordisk Foundation [NNF20CC0035580 to T.W., NNF16OC0021746 to T.W.]; Center for Microbial Secondary Metabolites (CeMiSt), Danish National Research Foundation [DNRF137 to T.W.]; ERC Starting Grant [948770-DECIPHER to M.H.M.]; Novel Antibacterial Compounds and Therapies Antagonising Resistance program (NACTAR) from the Dutch Research Council (NWO) [16440 to M.H.M.]; M.A is supported by the NWO Talent programme Veni science domain (VI.Veni.202.130). Funding for open access charge: Novo Nordisk Foundation.
PY - 2023/7/5
Y1 - 2023/7/5
N2 - Microorganisms produce small bioactive compounds as part of their secondary or specialised metabolism. Often, such metabolites have antimicrobial, anticancer, antifungal, antiviral or other bio-Activities and thus play an important role for applications in medicine and agriculture. In the past decade, genome mining has become a widely-used method to explore, access, and analyse the available biodiversity of these compounds. Since 2011, the 'antibiotics and secondary metabolite analysis shell-antiSMASH' (https://antismash.secondarymetabolites.org/) has supported researchers in their microbial genome mining tasks, both as a free to use web server and as a standalone tool under an OSI-Approved open source licence. It is currently the most widely used tool for detecting and characterising biosynthetic gene clusters (BGCs) in archaea, bacteria, and fungi. Here, we present the updated version 7 of antiSMASH. antiSMASH 7 increases the number of supported cluster types from 71 to 81, as well as containing improvements in the areas of chemical structure prediction, enzymatic assembly-line visualisation and gene cluster regulation.
AB - Microorganisms produce small bioactive compounds as part of their secondary or specialised metabolism. Often, such metabolites have antimicrobial, anticancer, antifungal, antiviral or other bio-Activities and thus play an important role for applications in medicine and agriculture. In the past decade, genome mining has become a widely-used method to explore, access, and analyse the available biodiversity of these compounds. Since 2011, the 'antibiotics and secondary metabolite analysis shell-antiSMASH' (https://antismash.secondarymetabolites.org/) has supported researchers in their microbial genome mining tasks, both as a free to use web server and as a standalone tool under an OSI-Approved open source licence. It is currently the most widely used tool for detecting and characterising biosynthetic gene clusters (BGCs) in archaea, bacteria, and fungi. Here, we present the updated version 7 of antiSMASH. antiSMASH 7 increases the number of supported cluster types from 71 to 81, as well as containing improvements in the areas of chemical structure prediction, enzymatic assembly-line visualisation and gene cluster regulation.
UR - http://www.scopus.com/inward/record.url?scp=85160292286&partnerID=8YFLogxK
U2 - 10.1093/nar/gkad344
DO - 10.1093/nar/gkad344
M3 - Article
C2 - 37140036
AN - SCOPUS:85160292286
VL - 51
SP - W46-W50
JO - Nucleic acids research
JF - Nucleic acids research
SN - 0305-1048
IS - W1
ER -