Details
| Original language | English |
|---|---|
| Pages (from-to) | 232-239 |
| Number of pages | 8 |
| Journal | International Journal of Psychiatry in Clinical Practice |
| Volume | 22 |
| Issue number | 3 |
| Early online date | 13 Dec 2017 |
| Publication status | Published - 3 Jul 2018 |
Abstract
Objective: A restrictive use of antipsychotic drugs in patients with Alzheimer’s disease (AD) is recommended due to an increased risk of cerebrovascular events and mortality. We hypothesise that the prescription of antipsychotics is associated with the patients’ socio-demographic and clinical status (e.g., dementia severity). Methods: The prescription of antipsychotics was cross-sectionally evaluated in 272 community-dwelling and 123 institutionalised patients with AD across all severity stages of dementia. The patients’ clinical characteristics covered the cognitive status, neuropsychiatric symptoms, daily activities, and quality of life (HrQoL). To determine associations with the use of antipsychotics bivariate and logistic regression analyses were conducted. Results: Totally, 25% of the patients were treated with antipsychotics. significantly less frequently than nursing home inhabitants (15.1% vs. 45.5%). Severely demented patients (MMSE 0–9) received antipsychotics most often (51.5%). Additionally, multiple regression analyses revealed a higher chance of prescription for participants with depressive symptoms (OR 2.3, 95% CI: 1.019–5.160) and those treated by neuropsychiatric specialists (OR 3.4, 95% CI: 1.408–8.328). Conclusions: Further longitudinal studies are required to assess the appropriateness of indications for antipsychotics and the reasons for a higher use in nursing home inhabitants and patients with severe dementia and depression.
Keywords
- Antipsychotics, BPSD, community-dwelling, dementia, nursing home
ASJC Scopus subject areas
- Medicine(all)
- Psychiatry and Mental health
Sustainable Development Goals
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In: International Journal of Psychiatry in Clinical Practice, Vol. 22, No. 3, 03.07.2018, p. 232-239.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Antipsychotic treatment of community-dwelling and institutionalised patients with dementia in Germany
AU - Hessmann, Philipp
AU - Dodel, Richard
AU - Baum, Erika
AU - Müller, Matthias J.
AU - Paschke, Greta
AU - Kis, Bernhard
AU - Zeidler, Jan
AU - Klora, Mike
AU - Reese, Jens Peter
AU - Balzer-Geldsetzer, Monika
N1 - Funding information: This study was supported by an unrestricted grant from the Ernst-and-Margot-Faber-Stiftung, Marburg, Germany.
PY - 2018/7/3
Y1 - 2018/7/3
N2 - Objective: A restrictive use of antipsychotic drugs in patients with Alzheimer’s disease (AD) is recommended due to an increased risk of cerebrovascular events and mortality. We hypothesise that the prescription of antipsychotics is associated with the patients’ socio-demographic and clinical status (e.g., dementia severity). Methods: The prescription of antipsychotics was cross-sectionally evaluated in 272 community-dwelling and 123 institutionalised patients with AD across all severity stages of dementia. The patients’ clinical characteristics covered the cognitive status, neuropsychiatric symptoms, daily activities, and quality of life (HrQoL). To determine associations with the use of antipsychotics bivariate and logistic regression analyses were conducted. Results: Totally, 25% of the patients were treated with antipsychotics. significantly less frequently than nursing home inhabitants (15.1% vs. 45.5%). Severely demented patients (MMSE 0–9) received antipsychotics most often (51.5%). Additionally, multiple regression analyses revealed a higher chance of prescription for participants with depressive symptoms (OR 2.3, 95% CI: 1.019–5.160) and those treated by neuropsychiatric specialists (OR 3.4, 95% CI: 1.408–8.328). Conclusions: Further longitudinal studies are required to assess the appropriateness of indications for antipsychotics and the reasons for a higher use in nursing home inhabitants and patients with severe dementia and depression.
AB - Objective: A restrictive use of antipsychotic drugs in patients with Alzheimer’s disease (AD) is recommended due to an increased risk of cerebrovascular events and mortality. We hypothesise that the prescription of antipsychotics is associated with the patients’ socio-demographic and clinical status (e.g., dementia severity). Methods: The prescription of antipsychotics was cross-sectionally evaluated in 272 community-dwelling and 123 institutionalised patients with AD across all severity stages of dementia. The patients’ clinical characteristics covered the cognitive status, neuropsychiatric symptoms, daily activities, and quality of life (HrQoL). To determine associations with the use of antipsychotics bivariate and logistic regression analyses were conducted. Results: Totally, 25% of the patients were treated with antipsychotics. significantly less frequently than nursing home inhabitants (15.1% vs. 45.5%). Severely demented patients (MMSE 0–9) received antipsychotics most often (51.5%). Additionally, multiple regression analyses revealed a higher chance of prescription for participants with depressive symptoms (OR 2.3, 95% CI: 1.019–5.160) and those treated by neuropsychiatric specialists (OR 3.4, 95% CI: 1.408–8.328). Conclusions: Further longitudinal studies are required to assess the appropriateness of indications for antipsychotics and the reasons for a higher use in nursing home inhabitants and patients with severe dementia and depression.
KW - Antipsychotics
KW - BPSD
KW - community-dwelling
KW - dementia
KW - nursing home
UR - http://www.scopus.com/inward/record.url?scp=85038037095&partnerID=8YFLogxK
U2 - 10.1080/13651501.2017.1414269
DO - 10.1080/13651501.2017.1414269
M3 - Article
C2 - 29235398
AN - SCOPUS:85038037095
VL - 22
SP - 232
EP - 239
JO - International Journal of Psychiatry in Clinical Practice
JF - International Journal of Psychiatry in Clinical Practice
SN - 1365-1501
IS - 3
ER -