Details
| Original language | English |
|---|---|
| Article number | ST-2011-A0246-A |
| Pages (from-to) | 1416-1426 |
| Number of pages | 11 |
| Journal | Synlett |
| Volume | 23 |
| Issue number | 10 |
| Publication status | Published - 2012 |
Abstract
Blocked mutants of Actinosynnema pretiosum, the producer of the highly cytotoxic antitumor agent ansamitocin, serve as powerful tools that allow synthetic chemists to generate natural product libraries. The power of this approach can be dramatically expanded when mutasynthesis is combined with chemical synthesis. This report provides illustrative examples of the application of this strategy to produce libraries based on the ansamycin antibiotics.
Keywords
- ansamitocins, antitumor agents, biosynthesis, mutasynthesis, semisynthesis
ASJC Scopus subject areas
- Chemistry(all)
- Organic Chemistry
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In: Synlett, Vol. 23, No. 10, ST-2011-A0246-A, 2012, p. 1416-1426.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Ansamitocin libraries by combining mutasynthesis with chemical synthesis; A new version of total synthesis
AU - Taft, Florian
AU - Eichner, Simone
AU - Knobloch, Tobias
AU - Harmrolfs, Kirsten
AU - Hermane, Jekaterina
AU - Kirschning, Andreas
PY - 2012
Y1 - 2012
N2 - Blocked mutants of Actinosynnema pretiosum, the producer of the highly cytotoxic antitumor agent ansamitocin, serve as powerful tools that allow synthetic chemists to generate natural product libraries. The power of this approach can be dramatically expanded when mutasynthesis is combined with chemical synthesis. This report provides illustrative examples of the application of this strategy to produce libraries based on the ansamycin antibiotics.
AB - Blocked mutants of Actinosynnema pretiosum, the producer of the highly cytotoxic antitumor agent ansamitocin, serve as powerful tools that allow synthetic chemists to generate natural product libraries. The power of this approach can be dramatically expanded when mutasynthesis is combined with chemical synthesis. This report provides illustrative examples of the application of this strategy to produce libraries based on the ansamycin antibiotics.
KW - ansamitocins
KW - antitumor agents
KW - biosynthesis
KW - mutasynthesis
KW - semisynthesis
UR - http://www.scopus.com/inward/record.url?scp=84861395914&partnerID=8YFLogxK
U2 - 10.1055/s-0031-1290695
DO - 10.1055/s-0031-1290695
M3 - Article
AN - SCOPUS:84861395914
VL - 23
SP - 1416
EP - 1426
JO - Synlett
JF - Synlett
SN - 0936-5214
IS - 10
M1 - ST-2011-A0246-A
ER -