ANGPTL8 (Betatrophin) is Expressed in Visceral Adipose Tissue and Relates to Human Hepatic Steatosis in Two Independent Clinical Collectives

Research output: Contribution to journal › Article › Research › peer review

Authors

  • Christian Von Loeffelholz
  • Andreas F.H. Pfeiffer
  • Johan F. Lock
  • Steffi Lieske
  • Stephanie Döcke
  • Veronica Murahovschi
  • Jennifer Kriebel
  • Tonia De Las Heras Gala
  • Harald Grallert
  • Natalia Rudovich
  • Martin Stockmann
  • Joachim Spranger
  • Gerhard Jahreis
  • Stefan R. Bornstein
  • George Lau
  • Aimin Xu
  • Jeanette Schulz-Menger
  • Louisa Exner
  • Sven Haufe
  • Jens Jordan
  • Stefan Engeli
  • Andreas L. Birkenfeld

External Research Organisations

  • German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE)
  • Friedrich Schiller University Jena
  • Charité - Universitätsmedizin Berlin
  • German Center for Diabetes Research (DZD)
  • Julius Maximilian University of Würzburg
  • University Hospital Carl Gustav Carus Dresden
  • Helmholtz Zentrum München - German Research Center for Environmental Health
  • The University of Hong Kong
  • Hannover Medical School (MHH)
  • German Aerospace Center (DLR)
  • Technische Universität Dresden
  • King's College London
  • Max Delbrück Center for Molecular Medicine (MDC) in the Helmholtz Association
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Details

Original languageEnglish
Pages (from-to)343-349
Number of pages7
JournalHormone and metabolic research
Volume49
Issue number5
Early online date28 Mar 2017
Publication statusPublished - 1 May 2017
Externally publishedYes

Abstract

Angiopoietin-like protein 8 (ANGPTL8)/betatrophin expression in visceral adipose tissue and associations with circulating fatty acid profile have not yet been investigated. Forty subjects were included in a cross-sectional study, 57 in a dietary weight reduction intervention. Circulating Angiopoietin-like protein 8/betatrophin was measured in all subjects. Liver and adipose tissue were sampled and plasma fatty acids and tissue Angiopoietin-like protein 8/betatrophin expression were evaluated in the cross-sectional study. In the intervention study oral glucose testing and liver magnetic resonance scanning at baseline and after 6 months were performed. Angiopoietin-like protein 8/betatrophin mRNA was increased in visceral compared to subcutaneous adipose tissue (p<0.001). Circulating ANGPTL8/betatrophin correlated with liver steatosis (r=0.42, p=0.047), triacylglycerols (r=0.34, p=0.046), saturated (r=0.43, p=0.022), monounsaturated (r=0.51, p=0.007), and polyunsaturated fatty acids (r=−0.53, p=0.004). In the intervention study, baseline Angiopoietin-like protein 8/betatrophin correlated with age (r=0.32, p=0.010) and triacylglycerols (r=0.30, p=0.02) and was increased with hepatic steatosis (p=0.033). Weight loss reduced liver fat by 45% and circulating Angiopoietin-like protein 8/betatrophin by 11% (288±17 vs. 258±17 pg/ml; p=0.015). Angiopoietin-like protein 8/betatrophin is related to liver steatosis, while visceral adipose tissue represents an additional site of expression in humans.

Keywords

    diabetes, fatty acids, fatty liver, HDL, hepatokine, insulin resistance, LDL, triacylglycerides

ASJC Scopus subject areas

Sustainable Development Goals

Cite this

ANGPTL8 (Betatrophin) is Expressed in Visceral Adipose Tissue and Relates to Human Hepatic Steatosis in Two Independent Clinical Collectives. / Von Loeffelholz, Christian; Pfeiffer, Andreas F.H.; Lock, Johan F. et al.
In: Hormone and metabolic research, Vol. 49, No. 5, 01.05.2017, p. 343-349.

Research output: Contribution to journal › Article › Research › peer review

Von Loeffelholz, C, Pfeiffer, AFH, Lock, JF, Lieske, S, Döcke, S, Murahovschi, V, Kriebel, J, De Las Heras Gala, T, Grallert, H, Rudovich, N, Stockmann, M, Spranger, J, Jahreis, G, Bornstein, SR, Lau, G, Xu, A, Schulz-Menger, J, Exner, L, Haufe, S, Jordan, J, Engeli, S & Birkenfeld, AL 2017, 'ANGPTL8 (Betatrophin) is Expressed in Visceral Adipose Tissue and Relates to Human Hepatic Steatosis in Two Independent Clinical Collectives', Hormone and metabolic research, vol. 49, no. 5, pp. 343-349. https://doi.org/10.1055/s-0043-102950
Von Loeffelholz, C., Pfeiffer, A. F. H., Lock, J. F., Lieske, S., Döcke, S., Murahovschi, V., Kriebel, J., De Las Heras Gala, T., Grallert, H., Rudovich, N., Stockmann, M., Spranger, J., Jahreis, G., Bornstein, S. R., Lau, G., Xu, A., Schulz-Menger, J., Exner, L., Haufe, S., ... Birkenfeld, A. L. (2017). ANGPTL8 (Betatrophin) is Expressed in Visceral Adipose Tissue and Relates to Human Hepatic Steatosis in Two Independent Clinical Collectives. Hormone and metabolic research, 49(5), 343-349. https://doi.org/10.1055/s-0043-102950
Von Loeffelholz C, Pfeiffer AFH, Lock JF, Lieske S, Döcke S, Murahovschi V et al. ANGPTL8 (Betatrophin) is Expressed in Visceral Adipose Tissue and Relates to Human Hepatic Steatosis in Two Independent Clinical Collectives. Hormone and metabolic research. 2017 May 1;49(5):343-349. Epub 2017 Mar 28. doi: 10.1055/s-0043-102950
Von Loeffelholz, Christian ; Pfeiffer, Andreas F.H. ; Lock, Johan F. et al. / ANGPTL8 (Betatrophin) is Expressed in Visceral Adipose Tissue and Relates to Human Hepatic Steatosis in Two Independent Clinical Collectives. In: Hormone and metabolic research. 2017 ; Vol. 49, No. 5. pp. 343-349.
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title = "ANGPTL8 (Betatrophin) is Expressed in Visceral Adipose Tissue and Relates to Human Hepatic Steatosis in Two Independent Clinical Collectives",
abstract = "Angiopoietin-like protein 8 (ANGPTL8)/betatrophin expression in visceral adipose tissue and associations with circulating fatty acid profile have not yet been investigated. Forty subjects were included in a cross-sectional study, 57 in a dietary weight reduction intervention. Circulating Angiopoietin-like protein 8/betatrophin was measured in all subjects. Liver and adipose tissue were sampled and plasma fatty acids and tissue Angiopoietin-like protein 8/betatrophin expression were evaluated in the cross-sectional study. In the intervention study oral glucose testing and liver magnetic resonance scanning at baseline and after 6 months were performed. Angiopoietin-like protein 8/betatrophin mRNA was increased in visceral compared to subcutaneous adipose tissue (p<0.001). Circulating ANGPTL8/betatrophin correlated with liver steatosis (r=0.42, p=0.047), triacylglycerols (r=0.34, p=0.046), saturated (r=0.43, p=0.022), monounsaturated (r=0.51, p=0.007), and polyunsaturated fatty acids (r=−0.53, p=0.004). In the intervention study, baseline Angiopoietin-like protein 8/betatrophin correlated with age (r=0.32, p=0.010) and triacylglycerols (r=0.30, p=0.02) and was increased with hepatic steatosis (p=0.033). Weight loss reduced liver fat by 45% and circulating Angiopoietin-like protein 8/betatrophin by 11% (288±17 vs. 258±17 pg/ml; p=0.015). Angiopoietin-like protein 8/betatrophin is related to liver steatosis, while visceral adipose tissue represents an additional site of expression in humans.",
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author = "{Von Loeffelholz}, Christian and Pfeiffer, {Andreas F.H.} and Lock, {Johan F.} and Steffi Lieske and Stephanie D{\"o}cke and Veronica Murahovschi and Jennifer Kriebel and {De Las Heras Gala}, Tonia and Harald Grallert and Natalia Rudovich and Martin Stockmann and Joachim Spranger and Gerhard Jahreis and Bornstein, {Stefan R.} and George Lau and Aimin Xu and Jeanette Schulz-Menger and Louisa Exner and Sven Haufe and Jens Jordan and Stefan Engeli and Birkenfeld, {Andreas L.}",
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T1 - ANGPTL8 (Betatrophin) is Expressed in Visceral Adipose Tissue and Relates to Human Hepatic Steatosis in Two Independent Clinical Collectives

AU - Von Loeffelholz, Christian

AU - Pfeiffer, Andreas F.H.

AU - Lock, Johan F.

AU - Lieske, Steffi

AU - Döcke, Stephanie

AU - Murahovschi, Veronica

AU - Kriebel, Jennifer

AU - De Las Heras Gala, Tonia

AU - Grallert, Harald

AU - Rudovich, Natalia

AU - Stockmann, Martin

AU - Spranger, Joachim

AU - Jahreis, Gerhard

AU - Bornstein, Stefan R.

AU - Lau, George

AU - Xu, Aimin

AU - Schulz-Menger, Jeanette

AU - Exner, Louisa

AU - Haufe, Sven

AU - Jordan, Jens

AU - Engeli, Stefan

AU - Birkenfeld, Andreas L.

PY - 2017/5/1

Y1 - 2017/5/1

N2 - Angiopoietin-like protein 8 (ANGPTL8)/betatrophin expression in visceral adipose tissue and associations with circulating fatty acid profile have not yet been investigated. Forty subjects were included in a cross-sectional study, 57 in a dietary weight reduction intervention. Circulating Angiopoietin-like protein 8/betatrophin was measured in all subjects. Liver and adipose tissue were sampled and plasma fatty acids and tissue Angiopoietin-like protein 8/betatrophin expression were evaluated in the cross-sectional study. In the intervention study oral glucose testing and liver magnetic resonance scanning at baseline and after 6 months were performed. Angiopoietin-like protein 8/betatrophin mRNA was increased in visceral compared to subcutaneous adipose tissue (p<0.001). Circulating ANGPTL8/betatrophin correlated with liver steatosis (r=0.42, p=0.047), triacylglycerols (r=0.34, p=0.046), saturated (r=0.43, p=0.022), monounsaturated (r=0.51, p=0.007), and polyunsaturated fatty acids (r=−0.53, p=0.004). In the intervention study, baseline Angiopoietin-like protein 8/betatrophin correlated with age (r=0.32, p=0.010) and triacylglycerols (r=0.30, p=0.02) and was increased with hepatic steatosis (p=0.033). Weight loss reduced liver fat by 45% and circulating Angiopoietin-like protein 8/betatrophin by 11% (288±17 vs. 258±17 pg/ml; p=0.015). Angiopoietin-like protein 8/betatrophin is related to liver steatosis, while visceral adipose tissue represents an additional site of expression in humans.

AB - Angiopoietin-like protein 8 (ANGPTL8)/betatrophin expression in visceral adipose tissue and associations with circulating fatty acid profile have not yet been investigated. Forty subjects were included in a cross-sectional study, 57 in a dietary weight reduction intervention. Circulating Angiopoietin-like protein 8/betatrophin was measured in all subjects. Liver and adipose tissue were sampled and plasma fatty acids and tissue Angiopoietin-like protein 8/betatrophin expression were evaluated in the cross-sectional study. In the intervention study oral glucose testing and liver magnetic resonance scanning at baseline and after 6 months were performed. Angiopoietin-like protein 8/betatrophin mRNA was increased in visceral compared to subcutaneous adipose tissue (p<0.001). Circulating ANGPTL8/betatrophin correlated with liver steatosis (r=0.42, p=0.047), triacylglycerols (r=0.34, p=0.046), saturated (r=0.43, p=0.022), monounsaturated (r=0.51, p=0.007), and polyunsaturated fatty acids (r=−0.53, p=0.004). In the intervention study, baseline Angiopoietin-like protein 8/betatrophin correlated with age (r=0.32, p=0.010) and triacylglycerols (r=0.30, p=0.02) and was increased with hepatic steatosis (p=0.033). Weight loss reduced liver fat by 45% and circulating Angiopoietin-like protein 8/betatrophin by 11% (288±17 vs. 258±17 pg/ml; p=0.015). Angiopoietin-like protein 8/betatrophin is related to liver steatosis, while visceral adipose tissue represents an additional site of expression in humans.

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