Details
| Original language | English |
|---|---|
| Article number | 9455132 |
| Pages (from-to) | 1607-1622 |
| Number of pages | 16 |
| Journal | Proc. IEEE |
| Volume | 109 |
| Issue number | 9 |
| Publication status | Published - Sept 2021 |
Abstract
The development and progress of high-throughput sequencing technologies have transformed the sequencing of DNA from a scientific research challenge to practice. With the release of the latest generation of sequencing machines, the cost of sequencing a whole human genome has dropped to less than 600. Such achievements open the door to personalized medicine, where it is expected that genomic information of patients will be analyzed as a standard practice. However, the associated costs, related to storing, transmitting, and processing the large volumes of data, are already comparable to the costs of sequencing. To support the design of new and interoperable solutions for the representation, compression, and management of genomic sequencing data, the Moving Picture Experts Group (MPEG) jointly with working group 5 of ISO/TC276 'Biotechnology' has started to produce the ISO/IEC 23092 series, known as MPEG-G. MPEG-G does not only offer higher levels of compression compared with the state of the art but it also provides new functionalities, such as built-in support for random access in the compressed domain, support for data protection mechanisms, flexible storage, and streaming capabilities. MPEG-G only specifies the decoding syntax of compressed bitstreams, as well as a file format and a transport format. This allows for the development of new encoding solutions with higher degrees of optimization while maintaining compatibility with any existing MPEG-G decoder.
Keywords
- Bioinformatics, computational biology, data compression, DNA, genomics, standardization
ASJC Scopus subject areas
- Engineering(all)
- Electrical and Electronic Engineering
- Computer Science(all)
- General Computer Science
Sustainable Development Goals
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In: Proc. IEEE, Vol. 109, No. 9, 9455132, 09.2021, p. 1607-1622.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - An Introduction to MPEG-G
T2 - The First Open ISO/IEC Standard for the Compression and Exchange of Genomic Sequencing Data.
AU - Voges, Jan
AU - Hernaez, Mikel
AU - Mattavelli, Marco
AU - Ostermann, Jörn
N1 - Acknowledgment: The development of the MPEG-G specification is a collaborative effort. The following people contributed to the actual MPEG-G development: Junaid J. Ahmad, Claudio Alberti, Simone Casale-Brunet, Patrick Cheung, Jaime Delgado, Jan Fostier, Silvia Llorente, Liud- mila S. Mainzer, Fabian Müntefering, Daniel Naro, Ibrahim Numanagi ́c, Idoia Ochoa, Tom Paridaens, Massimo Ravasi, Daniele Renzi, Paolo Ribeca, and Giorgio Zoia. MPEG received additional input from other experts, including Bonnie Berger, Noah Daniels, Nicolas Guex, Christian Iseli, Raymond Krasinski, Christian Rohlfing, S. Cenk Sahinalp, and Ioannis Xenarios.
PY - 2021/9
Y1 - 2021/9
N2 - The development and progress of high-throughput sequencing technologies have transformed the sequencing of DNA from a scientific research challenge to practice. With the release of the latest generation of sequencing machines, the cost of sequencing a whole human genome has dropped to less than 600. Such achievements open the door to personalized medicine, where it is expected that genomic information of patients will be analyzed as a standard practice. However, the associated costs, related to storing, transmitting, and processing the large volumes of data, are already comparable to the costs of sequencing. To support the design of new and interoperable solutions for the representation, compression, and management of genomic sequencing data, the Moving Picture Experts Group (MPEG) jointly with working group 5 of ISO/TC276 'Biotechnology' has started to produce the ISO/IEC 23092 series, known as MPEG-G. MPEG-G does not only offer higher levels of compression compared with the state of the art but it also provides new functionalities, such as built-in support for random access in the compressed domain, support for data protection mechanisms, flexible storage, and streaming capabilities. MPEG-G only specifies the decoding syntax of compressed bitstreams, as well as a file format and a transport format. This allows for the development of new encoding solutions with higher degrees of optimization while maintaining compatibility with any existing MPEG-G decoder.
AB - The development and progress of high-throughput sequencing technologies have transformed the sequencing of DNA from a scientific research challenge to practice. With the release of the latest generation of sequencing machines, the cost of sequencing a whole human genome has dropped to less than 600. Such achievements open the door to personalized medicine, where it is expected that genomic information of patients will be analyzed as a standard practice. However, the associated costs, related to storing, transmitting, and processing the large volumes of data, are already comparable to the costs of sequencing. To support the design of new and interoperable solutions for the representation, compression, and management of genomic sequencing data, the Moving Picture Experts Group (MPEG) jointly with working group 5 of ISO/TC276 'Biotechnology' has started to produce the ISO/IEC 23092 series, known as MPEG-G. MPEG-G does not only offer higher levels of compression compared with the state of the art but it also provides new functionalities, such as built-in support for random access in the compressed domain, support for data protection mechanisms, flexible storage, and streaming capabilities. MPEG-G only specifies the decoding syntax of compressed bitstreams, as well as a file format and a transport format. This allows for the development of new encoding solutions with higher degrees of optimization while maintaining compatibility with any existing MPEG-G decoder.
KW - Bioinformatics
KW - computational biology
KW - data compression
KW - DNA
KW - genomics
KW - standardization
UR - http://www.scopus.com/inward/record.url?scp=85112220633&partnerID=8YFLogxK
U2 - 10.1109/JPROC.2021.3082027
DO - 10.1109/JPROC.2021.3082027
M3 - Article
VL - 109
SP - 1607
EP - 1622
JO - Proc. IEEE
JF - Proc. IEEE
SN - 1558-2256
IS - 9
M1 - 9455132
ER -