Details
| Original language | English |
|---|---|
| Pages (from-to) | 8983-8992 |
| Number of pages | 10 |
| Journal | TETRAHEDRON |
| Volume | 51 |
| Issue number | 33 |
| Publication status | Published - 14 Aug 1995 |
Abstract
We describe herein an enantio- and diastereoselective total synthesis of two radicinin analogues 13 and 14. 13 has been subjected to biological tests, exhibiting the lowest toxicity of all radicinin analogues that have been investigated to date and it depresses the heart ventricular strip and histamine contraction. The key reaction to establish the radicinin skeleton is the reduction of the pseudo C2 symmetrical precursor 11 with the aid of TiCl4 and LiBH4.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Pharmacology, Toxicology and Pharmaceutics(all)
- Drug Discovery
- Chemistry(all)
- Organic Chemistry
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In: TETRAHEDRON, Vol. 51, No. 33, 14.08.1995, p. 8983-8992.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - An efficient synthesis of radicinin analogues
AU - Eh, Marcus
AU - Schomburg, Dietmar
AU - Schicht, Kathrin
AU - Kalesse, Markus
PY - 1995/8/14
Y1 - 1995/8/14
N2 - We describe herein an enantio- and diastereoselective total synthesis of two radicinin analogues 13 and 14. 13 has been subjected to biological tests, exhibiting the lowest toxicity of all radicinin analogues that have been investigated to date and it depresses the heart ventricular strip and histamine contraction. The key reaction to establish the radicinin skeleton is the reduction of the pseudo C2 symmetrical precursor 11 with the aid of TiCl4 and LiBH4.
AB - We describe herein an enantio- and diastereoselective total synthesis of two radicinin analogues 13 and 14. 13 has been subjected to biological tests, exhibiting the lowest toxicity of all radicinin analogues that have been investigated to date and it depresses the heart ventricular strip and histamine contraction. The key reaction to establish the radicinin skeleton is the reduction of the pseudo C2 symmetrical precursor 11 with the aid of TiCl4 and LiBH4.
UR - http://www.scopus.com/inward/record.url?scp=0029156824&partnerID=8YFLogxK
U2 - 10.1016/0040-4020(95)00491-P
DO - 10.1016/0040-4020(95)00491-P
M3 - Article
AN - SCOPUS:0029156824
VL - 51
SP - 8983
EP - 8992
JO - TETRAHEDRON
JF - TETRAHEDRON
SN - 0040-4020
IS - 33
ER -