Details
| Original language | English |
|---|---|
| Article number | 6771 |
| Number of pages | 12 |
| Journal | Sensors (Switzerland) |
| Volume | 20 |
| Issue number | 23 |
| Publication status | Published - 27 Nov 2020 |
Abstract
An all-optical plasmonic sensor platform designed for smartphones based on planar-optical waveguide structures integrated in a polymer chip is reported for the first time. To demonstrate the applicability of the sensor system for biosensing purposes, the detection of 25-hydroxyvitamin D (25OHD) in human serum samples using an AuNP-enhanced aptamer-based assay was demonstrated. With the aid of the developed assay sensitivity of 0.752 pixel/nM was achieved for 25OHD concentrations ranging from 0–100 nM. The waveguide structure of the sensor enables miniaturisation and parallelisation, thus, demonstrates the potential for simultaneous detection of various analytes including biomarkers. The entire optical arrangement can be integrated into a single polymer chip which allows for large scale and cost-efficient sensor fabrication. The broad utilization and access of smartphone electronics make the proposed design most attractive for its wider use in lab-on-chip applications.
Keywords
- Aptamers, Biosensor, Integrated optics, Optical waveguide, Surface plasmon resonance, Vitamin D
ASJC Scopus subject areas
- Chemistry(all)
- Analytical Chemistry
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Physics and Astronomy(all)
- Atomic and Molecular Physics, and Optics
- Physics and Astronomy(all)
- Instrumentation
- Engineering(all)
- Electrical and Electronic Engineering
Cite this
- Standard
- Harvard
- Apa
- Vancouver
- BibTeX
- RIS
In: Sensors (Switzerland), Vol. 20, No. 23, 6771, 27.11.2020.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - All-Optical Planar Polymer Waveguide-Based Biosensor Chip Designed for Smartphone-Assisted Detection of Vitamin D
AU - Walter, Johanna-Gabriela
AU - Alwis, Lourdes S.M.
AU - Roth, Bernhard
AU - Bremer, Kort
N1 - Funding Information: Funding: B.R. and K.B. acknowledges funding from the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany’s Excellence Strategy within the Cluster of Excellence PhoenixD (EXC 2122, Project ID 390833453). J.-G.W. and K.B. acknowledge support from the Bundesministerium für Wirtschaft und Energie (BMWi) as well as the European Social Fund (ESF) within Grant Number 03EFHNI059.
PY - 2020/11/27
Y1 - 2020/11/27
N2 - An all-optical plasmonic sensor platform designed for smartphones based on planar-optical waveguide structures integrated in a polymer chip is reported for the first time. To demonstrate the applicability of the sensor system for biosensing purposes, the detection of 25-hydroxyvitamin D (25OHD) in human serum samples using an AuNP-enhanced aptamer-based assay was demonstrated. With the aid of the developed assay sensitivity of 0.752 pixel/nM was achieved for 25OHD concentrations ranging from 0–100 nM. The waveguide structure of the sensor enables miniaturisation and parallelisation, thus, demonstrates the potential for simultaneous detection of various analytes including biomarkers. The entire optical arrangement can be integrated into a single polymer chip which allows for large scale and cost-efficient sensor fabrication. The broad utilization and access of smartphone electronics make the proposed design most attractive for its wider use in lab-on-chip applications.
AB - An all-optical plasmonic sensor platform designed for smartphones based on planar-optical waveguide structures integrated in a polymer chip is reported for the first time. To demonstrate the applicability of the sensor system for biosensing purposes, the detection of 25-hydroxyvitamin D (25OHD) in human serum samples using an AuNP-enhanced aptamer-based assay was demonstrated. With the aid of the developed assay sensitivity of 0.752 pixel/nM was achieved for 25OHD concentrations ranging from 0–100 nM. The waveguide structure of the sensor enables miniaturisation and parallelisation, thus, demonstrates the potential for simultaneous detection of various analytes including biomarkers. The entire optical arrangement can be integrated into a single polymer chip which allows for large scale and cost-efficient sensor fabrication. The broad utilization and access of smartphone electronics make the proposed design most attractive for its wider use in lab-on-chip applications.
KW - Aptamers
KW - Biosensor
KW - Integrated optics
KW - Optical waveguide
KW - Surface plasmon resonance
KW - Vitamin D
UR - http://www.scopus.com/inward/record.url?scp=85096720202&partnerID=8YFLogxK
U2 - 10.3390/s20236771
DO - 10.3390/s20236771
M3 - Article
AN - SCOPUS:85096720202
VL - 20
JO - Sensors (Switzerland)
JF - Sensors (Switzerland)
SN - 1424-8220
IS - 23
M1 - 6771
ER -