Details
| Original language | English |
|---|---|
| Article number | 107571 |
| Journal | Biotechnology advances |
| Volume | 43 |
| Publication status | Published - 1 Nov 2020 |
| Externally published | Yes |
Abstract
Antibiotic resistance is rising at a pace that is difficult to cope with; circumvention of this issue requires fast and efficient alternatives to conventional antibiotics. Algae inhabit a wide span of ecosystems, which contributes to their ability to synthesize diverse classes of highly active biogenic metabolites. Here, for the first time, we reviewed all possible algal metabolites with broad spectra antibacterial activity against pathogenic bacteria, including antibiotic-resistant strains, and categorized different metabolites of both freshwater and marine algae, linking them on the basis of their target sites and mechanistic actions along with their probable nanoconjugates. Algae can be considered a boon for novel drug discovery in the era of antibiotic resistance, as various algal primary and secondary metabolites possess potential antibacterial properties. The diversity of these metabolites from indigenous sources provides a promising gateway enabling researchers and pharmaceutical companies to develop novel nontoxic, cost-effective and highly efficient antibacterial medicines.
Keywords
- Anti-Bacterial Agents/pharmacology, Bacteria, Drug Resistance, Microbial, Ecosystem, Plants, Multidrug resistant (MDR), Marine, Antibacterial activity, Freshwater, Algal metabolites
ASJC Scopus subject areas
- Immunology and Microbiology(all)
- Applied Microbiology and Biotechnology
- Chemical Engineering(all)
- Bioengineering
- Biochemistry, Genetics and Molecular Biology(all)
- Biotechnology
Sustainable Development Goals
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In: Biotechnology advances, Vol. 43, 107571, 01.11.2020.
Research output: Contribution to journal › Article › Research
}
TY - JOUR
T1 - Algal metabolites
T2 - An inevitable substitute for antibiotics
AU - Bhowmick, Sukanya
AU - Mazumdar, Aninda
AU - Moulick, Amitava
AU - Adam, Vojtech
N1 - Funding information: This work was financially supported by CEITEC 2020 ( LQ1601 ) and by the ERDF project “Multidisciplinary research to increase the application potential of nanomaterials in agriculture” (No. CZ.02.1.01/0.0/0.0/16_025/0007314).
PY - 2020/11/1
Y1 - 2020/11/1
N2 - Antibiotic resistance is rising at a pace that is difficult to cope with; circumvention of this issue requires fast and efficient alternatives to conventional antibiotics. Algae inhabit a wide span of ecosystems, which contributes to their ability to synthesize diverse classes of highly active biogenic metabolites. Here, for the first time, we reviewed all possible algal metabolites with broad spectra antibacterial activity against pathogenic bacteria, including antibiotic-resistant strains, and categorized different metabolites of both freshwater and marine algae, linking them on the basis of their target sites and mechanistic actions along with their probable nanoconjugates. Algae can be considered a boon for novel drug discovery in the era of antibiotic resistance, as various algal primary and secondary metabolites possess potential antibacterial properties. The diversity of these metabolites from indigenous sources provides a promising gateway enabling researchers and pharmaceutical companies to develop novel nontoxic, cost-effective and highly efficient antibacterial medicines.
AB - Antibiotic resistance is rising at a pace that is difficult to cope with; circumvention of this issue requires fast and efficient alternatives to conventional antibiotics. Algae inhabit a wide span of ecosystems, which contributes to their ability to synthesize diverse classes of highly active biogenic metabolites. Here, for the first time, we reviewed all possible algal metabolites with broad spectra antibacterial activity against pathogenic bacteria, including antibiotic-resistant strains, and categorized different metabolites of both freshwater and marine algae, linking them on the basis of their target sites and mechanistic actions along with their probable nanoconjugates. Algae can be considered a boon for novel drug discovery in the era of antibiotic resistance, as various algal primary and secondary metabolites possess potential antibacterial properties. The diversity of these metabolites from indigenous sources provides a promising gateway enabling researchers and pharmaceutical companies to develop novel nontoxic, cost-effective and highly efficient antibacterial medicines.
KW - Anti-Bacterial Agents/pharmacology
KW - Bacteria
KW - Drug Resistance, Microbial
KW - Ecosystem
KW - Plants
KW - Multidrug resistant (MDR)
KW - Marine
KW - Antibacterial activity
KW - Freshwater
KW - Algal metabolites
UR - http://www.scopus.com/inward/record.url?scp=85086525386&partnerID=8YFLogxK
U2 - 10.1016/j.biotechadv.2020.107571
DO - 10.1016/j.biotechadv.2020.107571
M3 - Article
C2 - 32505655
VL - 43
JO - Biotechnology advances
JF - Biotechnology advances
SN - 0734-9750
M1 - 107571
ER -