Details
| Original language | English |
|---|---|
| Pages (from-to) | 2436-2439 |
| Number of pages | 4 |
| Journal | ACS catalysis |
| Volume | 3 |
| Issue number | 11 |
| Early online date | 20 Sept 2013 |
| Publication status | Published - 1 Nov 2013 |
| Externally published | Yes |
Abstract
The oxidative lactonization of 1,4-, 1,5-, and 1,6-diols using horse liver alcohol dehydrogenase (HLADH) is reported. Molecular oxygen was used as terminal electron acceptor by utilization of the laccase-mediator concept to regenerate the oxidized nicotinamide cofactor and producing water as sole byproduct. Spontaneous hydrolysis of the lactone products was identified as a major limiting factor toward preparative application of the system, which can be alleviated by using a two liquid phase approach to extracting the product into an organic solvent.
Keywords
- alcohol dehydrogenase, biocatalysis, chemoenzymatic cascades, cofactor regeneration, laccase-mediator system, lactones, two liquid phase systems
ASJC Scopus subject areas
- Chemical Engineering(all)
- Catalysis
- Chemistry(all)
- General Chemistry
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In: ACS catalysis, Vol. 3, No. 11, 01.11.2013, p. 2436-2439.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - Access to lactone building blocks via horse liver alcohol dehydrogenase-catalyzed oxidative lactonization
AU - Kara, Selin
AU - Spickermann, Dominik
AU - Schrittwieser, Joerg H.
AU - Weckbecker, Andrea
AU - Leggewie, Christian
AU - Arends, Isabel W.C.E.
AU - Hollmann, Frank
PY - 2013/11/1
Y1 - 2013/11/1
N2 - The oxidative lactonization of 1,4-, 1,5-, and 1,6-diols using horse liver alcohol dehydrogenase (HLADH) is reported. Molecular oxygen was used as terminal electron acceptor by utilization of the laccase-mediator concept to regenerate the oxidized nicotinamide cofactor and producing water as sole byproduct. Spontaneous hydrolysis of the lactone products was identified as a major limiting factor toward preparative application of the system, which can be alleviated by using a two liquid phase approach to extracting the product into an organic solvent.
AB - The oxidative lactonization of 1,4-, 1,5-, and 1,6-diols using horse liver alcohol dehydrogenase (HLADH) is reported. Molecular oxygen was used as terminal electron acceptor by utilization of the laccase-mediator concept to regenerate the oxidized nicotinamide cofactor and producing water as sole byproduct. Spontaneous hydrolysis of the lactone products was identified as a major limiting factor toward preparative application of the system, which can be alleviated by using a two liquid phase approach to extracting the product into an organic solvent.
KW - alcohol dehydrogenase
KW - biocatalysis
KW - chemoenzymatic cascades
KW - cofactor regeneration
KW - laccase-mediator system
KW - lactones
KW - two liquid phase systems
UR - http://www.scopus.com/inward/record.url?scp=84887398585&partnerID=8YFLogxK
U2 - 10.1021/cs400535c
DO - 10.1021/cs400535c
M3 - Article
AN - SCOPUS:84887398585
VL - 3
SP - 2436
EP - 2439
JO - ACS catalysis
JF - ACS catalysis
SN - 2155-5435
IS - 11
ER -