Details
| Original language | English |
|---|---|
| Pages (from-to) | 3032-3038 |
| Number of pages | 7 |
| Journal | Journal of Materials Chemistry B |
| Volume | 13 |
| Issue number | 9 |
| Publication status | Published - 21 Jan 2025 |
Abstract
The increasing prevalence of antimicrobial resistance and adverse effects of systemic treatments calls for urgent reevaluation of current methods that rely on excessive, uncontrolled drug administration. In recent years triggerable systems have emerged as promising alternatives, enabling time-controlled and localized drug release, which are only activated if necessary. Light is an obvious candidate as an external trigger, since it allows for localized activation, is non-invasive and its wavelength and intensity can be tailored to fit the demands of the drug release system. Such localized and triggered systems minimize off-target effects and undesired exposure, making it a promising tool for combating health threats such as antimicrobial resistance. However, the limited tissue penetration of visible light significantly limits the applicability of this concept in vivo. Here, we introduce an innovative triggerable drug release system, based on mono-, bi-, and tri-functionalized mesoporous organosilica particles (MOPs). The limited tissue penetration is addressed by an advanced trigger system featuring two-photon absorption. Two-photon absorption enables utilization of near-infrared (NIR) light as a trigger, which is known to exhibit an enhanced penetration depth. The particles are designed to release reactive oxygen species (ROS) upon NIR irradiation and undergo Förster resonance energy transfer (FRET) to a ROS producing dye. Moreover, by oxidative cleavage, an additional therapeutic agent is released in a cascade reaction, enhancing the system's effectiveness. The ROS release is microscopically demonstrated in situ and, for the first time, release of a fluorescent compound (therapeutic agent) in a cascade reaction is observed in real-time, providing valuable insights into the behavior and performance of our particles. This novel sequential dual-release platform for light-triggered therapeutic delivery has great potential for advanced therapeutic applications in both superficial and deep tissue treatments.
ASJC Scopus subject areas
- Chemistry(all)
- General Chemistry
- Engineering(all)
- Biomedical Engineering
- Materials Science(all)
- General Materials Science
Cite this
- Standard
- Harvard
- Apa
- Vancouver
- BibTeX
- RIS
In: Journal of Materials Chemistry B, Vol. 13, No. 9, 21.01.2025, p. 3032-3038.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - A versatile two-light mode triggered system for highly localized sequential release of reactive oxygen species and conjugated drugs from mesoporous organosilica particles
AU - Bronner, Hannah
AU - Doll-Nikutta, Katharina
AU - Donath, Sören
AU - Ehlert, Nina
AU - Krysiak, Yaşar
AU - Heisterkamp, Alexander
AU - Stiesch, Meike
AU - Kalies, Stefan
AU - Polarz, Sebastian
N1 - Publisher Copyright: © 2025 The Royal Society of Chemistry.
PY - 2025/1/21
Y1 - 2025/1/21
N2 - The increasing prevalence of antimicrobial resistance and adverse effects of systemic treatments calls for urgent reevaluation of current methods that rely on excessive, uncontrolled drug administration. In recent years triggerable systems have emerged as promising alternatives, enabling time-controlled and localized drug release, which are only activated if necessary. Light is an obvious candidate as an external trigger, since it allows for localized activation, is non-invasive and its wavelength and intensity can be tailored to fit the demands of the drug release system. Such localized and triggered systems minimize off-target effects and undesired exposure, making it a promising tool for combating health threats such as antimicrobial resistance. However, the limited tissue penetration of visible light significantly limits the applicability of this concept in vivo. Here, we introduce an innovative triggerable drug release system, based on mono-, bi-, and tri-functionalized mesoporous organosilica particles (MOPs). The limited tissue penetration is addressed by an advanced trigger system featuring two-photon absorption. Two-photon absorption enables utilization of near-infrared (NIR) light as a trigger, which is known to exhibit an enhanced penetration depth. The particles are designed to release reactive oxygen species (ROS) upon NIR irradiation and undergo Förster resonance energy transfer (FRET) to a ROS producing dye. Moreover, by oxidative cleavage, an additional therapeutic agent is released in a cascade reaction, enhancing the system's effectiveness. The ROS release is microscopically demonstrated in situ and, for the first time, release of a fluorescent compound (therapeutic agent) in a cascade reaction is observed in real-time, providing valuable insights into the behavior and performance of our particles. This novel sequential dual-release platform for light-triggered therapeutic delivery has great potential for advanced therapeutic applications in both superficial and deep tissue treatments.
AB - The increasing prevalence of antimicrobial resistance and adverse effects of systemic treatments calls for urgent reevaluation of current methods that rely on excessive, uncontrolled drug administration. In recent years triggerable systems have emerged as promising alternatives, enabling time-controlled and localized drug release, which are only activated if necessary. Light is an obvious candidate as an external trigger, since it allows for localized activation, is non-invasive and its wavelength and intensity can be tailored to fit the demands of the drug release system. Such localized and triggered systems minimize off-target effects and undesired exposure, making it a promising tool for combating health threats such as antimicrobial resistance. However, the limited tissue penetration of visible light significantly limits the applicability of this concept in vivo. Here, we introduce an innovative triggerable drug release system, based on mono-, bi-, and tri-functionalized mesoporous organosilica particles (MOPs). The limited tissue penetration is addressed by an advanced trigger system featuring two-photon absorption. Two-photon absorption enables utilization of near-infrared (NIR) light as a trigger, which is known to exhibit an enhanced penetration depth. The particles are designed to release reactive oxygen species (ROS) upon NIR irradiation and undergo Förster resonance energy transfer (FRET) to a ROS producing dye. Moreover, by oxidative cleavage, an additional therapeutic agent is released in a cascade reaction, enhancing the system's effectiveness. The ROS release is microscopically demonstrated in situ and, for the first time, release of a fluorescent compound (therapeutic agent) in a cascade reaction is observed in real-time, providing valuable insights into the behavior and performance of our particles. This novel sequential dual-release platform for light-triggered therapeutic delivery has great potential for advanced therapeutic applications in both superficial and deep tissue treatments.
UR - http://www.scopus.com/inward/record.url?scp=85216613782&partnerID=8YFLogxK
U2 - 10.1039/d4tb02691h
DO - 10.1039/d4tb02691h
M3 - Article
AN - SCOPUS:85216613782
VL - 13
SP - 3032
EP - 3038
JO - Journal of Materials Chemistry B
JF - Journal of Materials Chemistry B
SN - 2050-750X
IS - 9
ER -