Details
| Translated title of the contribution | Wärmesensibles Polymer und dessen Verwendung in einem Zellkulturträger |
|---|---|
| Original language | English |
| Patent number | EP3301121A1 |
| IPC | C08G65/22,C08G65/332,C08G65/331,C08G65/26 |
| Priority date | 30 Sept 2016 |
| Filing date | 30 Sept 2016 |
| Publication status | Published - 4 Apr 2018 |
| Externally published | Yes |
Abstract
The present invention relates to a thermoresponsive polymer comprising a linear polyether chain of the general formulae (I) Nu-[CH 2 -CR 1 R 2 O] m -[CH 2 -CR 3 R 4 O] m -[CH 2 -CR 5 R 6 O] o -[CH 2 -CR 7 R 8 O] p -H; wherein R 1 , R 3 , R 5 and R 7 are in each case H or a C 1 -C 10 alkyl side chain, wherein R 1 , R 3 , R 5 and R 7 may be the same or different; R 2 and R 4 are in each case a side chain comprising at least one thermoresponsive moiety, wherein R 2 and R 4 may be the same or different; R 6 and R 8 are in each case H, a moiety containing at least one C=C double bond or a photo-crosslinkable moiety selected from a group of aromatic and heteroaromatic compounds, wherein R 6 and R 8 may the same or different, wherein at least one of R 6 and R 8 has to be a photo-crosslinkable moiety, Nu is nucleophilic moiety selected from a group comprising halogen or alkoxy; m, n are in each case or in sum 10-5000, preferably 10-1000, more preferably 100-500; o, p are in each case 1-20 or in sum 2-20, preferably 3-15, more preferably 5-10. The invention also relates to a cell substrate support comprising the polymer.
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Patent No.: EP3301121A1. Apr 04, 2018.
Research output: Patent
}
TY - PAT
T1 - A thermoresponsive polymer and its use in a cell culture support
AU - Weinhart, Heidemarie
AU - Stöbener, Daniel
PY - 2018/4/4
Y1 - 2018/4/4
N2 - The present invention relates to a thermoresponsive polymer comprising a linear polyether chain of the general formulae (I) Nu-[CH 2 -CR 1 R 2 O] m -[CH 2 -CR 3 R 4 O] m -[CH 2 -CR 5 R 6 O] o -[CH 2 -CR 7 R 8 O] p -H; wherein R 1 , R 3 , R 5 and R 7 are in each case H or a C 1 -C 10 alkyl side chain, wherein R 1 , R 3 , R 5 and R 7 may be the same or different; R 2 and R 4 are in each case a side chain comprising at least one thermoresponsive moiety, wherein R 2 and R 4 may be the same or different; R 6 and R 8 are in each case H, a moiety containing at least one C=C double bond or a photo-crosslinkable moiety selected from a group of aromatic and heteroaromatic compounds, wherein R 6 and R 8 may the same or different, wherein at least one of R 6 and R 8 has to be a photo-crosslinkable moiety, Nu is nucleophilic moiety selected from a group comprising halogen or alkoxy; m, n are in each case or in sum 10-5000, preferably 10-1000, more preferably 100-500; o, p are in each case 1-20 or in sum 2-20, preferably 3-15, more preferably 5-10. The invention also relates to a cell substrate support comprising the polymer.
AB - The present invention relates to a thermoresponsive polymer comprising a linear polyether chain of the general formulae (I) Nu-[CH 2 -CR 1 R 2 O] m -[CH 2 -CR 3 R 4 O] m -[CH 2 -CR 5 R 6 O] o -[CH 2 -CR 7 R 8 O] p -H; wherein R 1 , R 3 , R 5 and R 7 are in each case H or a C 1 -C 10 alkyl side chain, wherein R 1 , R 3 , R 5 and R 7 may be the same or different; R 2 and R 4 are in each case a side chain comprising at least one thermoresponsive moiety, wherein R 2 and R 4 may be the same or different; R 6 and R 8 are in each case H, a moiety containing at least one C=C double bond or a photo-crosslinkable moiety selected from a group of aromatic and heteroaromatic compounds, wherein R 6 and R 8 may the same or different, wherein at least one of R 6 and R 8 has to be a photo-crosslinkable moiety, Nu is nucleophilic moiety selected from a group comprising halogen or alkoxy; m, n are in each case or in sum 10-5000, preferably 10-1000, more preferably 100-500; o, p are in each case 1-20 or in sum 2-20, preferably 3-15, more preferably 5-10. The invention also relates to a cell substrate support comprising the polymer.
M3 - Patent
M1 - EP3301121A1
Y2 - 2016/09/30
ER -