Details
| Original language | English |
|---|---|
| Pages (from-to) | 2161-2170 |
| Number of pages | 10 |
| Journal | European Journal of Radiology |
| Volume | 84 |
| Issue number | 11 |
| Early online date | 5 Aug 2015 |
| Publication status | Published - Nov 2015 |
Abstract
Background Previous studies showed that myocardial T2 relaxation times measured by cardiac T2-mapping vary significantly depending on sequence and field strength. Therefore, a systematic comparison of different T2-mapping sequences and the establishment of dedicated T2 reference values is mandatory for diagnostic decision-making. Methods Phantom experiments using gel probes with a range of different T1 and T2 times were performed on a clinical 1.5T and 3T scanner. In addition, 30 healthy volunteers were examined at 1.5 and 3T in immediate succession. In each examination, three different T2-mapping sequences were performed at three short-axis slices: Multi Echo Spin Echo (MESE), T2-prepared balanced SSFP (T2prep), and Gradient Spin Echo with and without fat saturation (GraSEFS/GraSE). Segmented T2-Maps were generated according to the AHA 16-segment model and statistical analysis was performed. Results Significant intra-individual differences between mean T2 times were observed for all sequences. In general, T2prep resulted in lowest and GraSE in highest T2 times. A significant variation with field strength was observed for mean T2 in phantom as well as in vivo, with higher T2 values at 1.5T compared to 3T, regardless of the sequence used. Segmental T2 values for each sequence at 1.5 and 3T are presented. Conclusions Despite a careful selection of sequence parameters and volunteers, significant variations of the measured T2 values were observed between field strengths, MR sequences and myocardial segments. Therefore, we present segmental T2 values for each sequence at 1.5 and 3T with the inherent potential to serve as reference values for future studies.
Keywords
- Cardiovascular magnetic resonance imaging, Parametric imaging, Phantom study, T2 mapping
ASJC Scopus subject areas
- Medicine(all)
- Radiology Nuclear Medicine and imaging
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In: European Journal of Radiology, Vol. 84, No. 11, 11.2015, p. 2161-2170.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - A systematic evaluation of three different cardiac T2-mapping sequences at 1.5 and 3T in healthy volunteers
AU - Baeßler, Bettina
AU - Schaarschmidt, Frank
AU - Stehning, Christian
AU - Schnackenburg, Bernhard
AU - Maintz, David
AU - Bunck, Alexander C.
N1 - Publisher Copyright: © 2015 Elsevier Ireland Ltd. All rights reserved.
PY - 2015/11
Y1 - 2015/11
N2 - Background Previous studies showed that myocardial T2 relaxation times measured by cardiac T2-mapping vary significantly depending on sequence and field strength. Therefore, a systematic comparison of different T2-mapping sequences and the establishment of dedicated T2 reference values is mandatory for diagnostic decision-making. Methods Phantom experiments using gel probes with a range of different T1 and T2 times were performed on a clinical 1.5T and 3T scanner. In addition, 30 healthy volunteers were examined at 1.5 and 3T in immediate succession. In each examination, three different T2-mapping sequences were performed at three short-axis slices: Multi Echo Spin Echo (MESE), T2-prepared balanced SSFP (T2prep), and Gradient Spin Echo with and without fat saturation (GraSEFS/GraSE). Segmented T2-Maps were generated according to the AHA 16-segment model and statistical analysis was performed. Results Significant intra-individual differences between mean T2 times were observed for all sequences. In general, T2prep resulted in lowest and GraSE in highest T2 times. A significant variation with field strength was observed for mean T2 in phantom as well as in vivo, with higher T2 values at 1.5T compared to 3T, regardless of the sequence used. Segmental T2 values for each sequence at 1.5 and 3T are presented. Conclusions Despite a careful selection of sequence parameters and volunteers, significant variations of the measured T2 values were observed between field strengths, MR sequences and myocardial segments. Therefore, we present segmental T2 values for each sequence at 1.5 and 3T with the inherent potential to serve as reference values for future studies.
AB - Background Previous studies showed that myocardial T2 relaxation times measured by cardiac T2-mapping vary significantly depending on sequence and field strength. Therefore, a systematic comparison of different T2-mapping sequences and the establishment of dedicated T2 reference values is mandatory for diagnostic decision-making. Methods Phantom experiments using gel probes with a range of different T1 and T2 times were performed on a clinical 1.5T and 3T scanner. In addition, 30 healthy volunteers were examined at 1.5 and 3T in immediate succession. In each examination, three different T2-mapping sequences were performed at three short-axis slices: Multi Echo Spin Echo (MESE), T2-prepared balanced SSFP (T2prep), and Gradient Spin Echo with and without fat saturation (GraSEFS/GraSE). Segmented T2-Maps were generated according to the AHA 16-segment model and statistical analysis was performed. Results Significant intra-individual differences between mean T2 times were observed for all sequences. In general, T2prep resulted in lowest and GraSE in highest T2 times. A significant variation with field strength was observed for mean T2 in phantom as well as in vivo, with higher T2 values at 1.5T compared to 3T, regardless of the sequence used. Segmental T2 values for each sequence at 1.5 and 3T are presented. Conclusions Despite a careful selection of sequence parameters and volunteers, significant variations of the measured T2 values were observed between field strengths, MR sequences and myocardial segments. Therefore, we present segmental T2 values for each sequence at 1.5 and 3T with the inherent potential to serve as reference values for future studies.
KW - Cardiovascular magnetic resonance imaging
KW - Parametric imaging
KW - Phantom study
KW - T2 mapping
UR - http://www.scopus.com/inward/record.url?scp=84944352369&partnerID=8YFLogxK
U2 - 10.1016/j.ejrad.2015.08.002
DO - 10.1016/j.ejrad.2015.08.002
M3 - Article
C2 - 26276731
AN - SCOPUS:84944352369
VL - 84
SP - 2161
EP - 2170
JO - European Journal of Radiology
JF - European Journal of Radiology
SN - 0720-048X
IS - 11
ER -