Details
| Original language | English |
|---|---|
| Pages (from-to) | 2574-2580 |
| Number of pages | 7 |
| Journal | Journal of Biomedical Materials Research - Part B Applied Biomaterials |
| Volume | 105 |
| Issue number | 8 |
| Early online date | 4 Oct 2016 |
| Publication status | Published - Nov 2017 |
Abstract
In cochlear implant (CI) patients, an increase in electrode impedance due to fibrotic encapsulation is frequently observed. Several attempts have been proposed to reduce fibroblast growth at the electrode contacts, but none proved to be satisfactory so far. Here, a silicone fiber coating of the electrode contacts is presented that provides a complex micro-scale surface topography and increases hydrophobicity to inhibit fibroblast growth and adhesion. A silicone fiber electrospinning process was developed to create a thin and porous fiber mesh. Fiber coatings were applied on graphite specimen holders, glass cover slips and CI electrode contacts. For characterization of the coating's pore distribution, water contact angle and electrical impedance were analyzed. Cytotoxicity and in vitro fibroblast growth were evaluated to assess biological efficacy of the coatings. It could be shown that the silicone fiber mesh itself had only minor influence on electrode impedance. A uniform, hydrophobic fiber coating could be achieved that decreased fibroblast growth without showing toxic effects. Finally, CI electrode contacts were successfully coated in order to present this promising approach for a long-term improvement of CI electrodes. We are one of the first groups that could successfully adapt the electrospinning technique on the utilization of silicone. Silicone was chosen because of its high hydrophobicity, chemical stability and excellent biocompatibility and as it is one of the biomaterials already used in CIs.
Keywords
- cochlear implant, electrospinning, silicone fiber
ASJC Scopus subject areas
- Materials Science(all)
- Biomaterials
- Engineering(all)
- Biomedical Engineering
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In: Journal of Biomedical Materials Research - Part B Applied Biomaterials, Vol. 105, No. 8, 11.2017, p. 2574-2580.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - A silicone fiber coating as approach for the reduction of fibroblast growth on implant electrodes
AU - Dencker, Folke
AU - Dreyer, Lutz
AU - Müller, Dietrich
AU - Zernetsch, Holger
AU - Paasche, Gerrit
AU - Sindelar, Ralf
AU - Glasmacher, Birgit
N1 - Publisher Copyright: © 2016 Wiley Periodicals, Inc. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2017/11
Y1 - 2017/11
N2 - In cochlear implant (CI) patients, an increase in electrode impedance due to fibrotic encapsulation is frequently observed. Several attempts have been proposed to reduce fibroblast growth at the electrode contacts, but none proved to be satisfactory so far. Here, a silicone fiber coating of the electrode contacts is presented that provides a complex micro-scale surface topography and increases hydrophobicity to inhibit fibroblast growth and adhesion. A silicone fiber electrospinning process was developed to create a thin and porous fiber mesh. Fiber coatings were applied on graphite specimen holders, glass cover slips and CI electrode contacts. For characterization of the coating's pore distribution, water contact angle and electrical impedance were analyzed. Cytotoxicity and in vitro fibroblast growth were evaluated to assess biological efficacy of the coatings. It could be shown that the silicone fiber mesh itself had only minor influence on electrode impedance. A uniform, hydrophobic fiber coating could be achieved that decreased fibroblast growth without showing toxic effects. Finally, CI electrode contacts were successfully coated in order to present this promising approach for a long-term improvement of CI electrodes. We are one of the first groups that could successfully adapt the electrospinning technique on the utilization of silicone. Silicone was chosen because of its high hydrophobicity, chemical stability and excellent biocompatibility and as it is one of the biomaterials already used in CIs.
AB - In cochlear implant (CI) patients, an increase in electrode impedance due to fibrotic encapsulation is frequently observed. Several attempts have been proposed to reduce fibroblast growth at the electrode contacts, but none proved to be satisfactory so far. Here, a silicone fiber coating of the electrode contacts is presented that provides a complex micro-scale surface topography and increases hydrophobicity to inhibit fibroblast growth and adhesion. A silicone fiber electrospinning process was developed to create a thin and porous fiber mesh. Fiber coatings were applied on graphite specimen holders, glass cover slips and CI electrode contacts. For characterization of the coating's pore distribution, water contact angle and electrical impedance were analyzed. Cytotoxicity and in vitro fibroblast growth were evaluated to assess biological efficacy of the coatings. It could be shown that the silicone fiber mesh itself had only minor influence on electrode impedance. A uniform, hydrophobic fiber coating could be achieved that decreased fibroblast growth without showing toxic effects. Finally, CI electrode contacts were successfully coated in order to present this promising approach for a long-term improvement of CI electrodes. We are one of the first groups that could successfully adapt the electrospinning technique on the utilization of silicone. Silicone was chosen because of its high hydrophobicity, chemical stability and excellent biocompatibility and as it is one of the biomaterials already used in CIs.
KW - cochlear implant
KW - electrospinning
KW - silicone fiber
UR - http://www.scopus.com/inward/record.url?scp=84990180469&partnerID=8YFLogxK
U2 - 10.1002/jbm.b.33798
DO - 10.1002/jbm.b.33798
M3 - Article
C2 - 27701814
AN - SCOPUS:84990180469
VL - 105
SP - 2574
EP - 2580
JO - Journal of Biomedical Materials Research - Part B Applied Biomaterials
JF - Journal of Biomedical Materials Research - Part B Applied Biomaterials
SN - 1552-4973
IS - 8
ER -