Details
| Original language | English |
|---|---|
| Pages (from-to) | 5503-5510 |
| Number of pages | 8 |
| Journal | Organic and Biomolecular Chemistry |
| Volume | 9 |
| Issue number | 15 |
| Publication status | Published - 7 Aug 2011 |
Abstract
A practical synthesis of the Rho-Kinase inhibitor Y-27632 and two new fluoro derivatives was achieved in seven steps and with a good overall yield of 45% starting from commercially available (R)-1-phenylethylamine. Compared to Y-27632 the new fluoro derivatives showed reduced or no effect on hPSC vitality and expansion after dissociation in human pluripotent stem cells.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Chemistry(all)
- Physical and Theoretical Chemistry
- Chemistry(all)
- Organic Chemistry
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In: Organic and Biomolecular Chemistry, Vol. 9, No. 15, 07.08.2011, p. 5503-5510.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - A practical synthesis of Rho-Kinase inhibitor Y-27632 and fluoro derivatives and their evaluation in human pluripotent stem cells
AU - Paleek, Jií
AU - Zweigerdt, Robert
AU - Olmer, Ruth
AU - Martin, Ulrich
AU - Kirschning, Andreas
AU - Dräger, Gerald
PY - 2011/8/7
Y1 - 2011/8/7
N2 - A practical synthesis of the Rho-Kinase inhibitor Y-27632 and two new fluoro derivatives was achieved in seven steps and with a good overall yield of 45% starting from commercially available (R)-1-phenylethylamine. Compared to Y-27632 the new fluoro derivatives showed reduced or no effect on hPSC vitality and expansion after dissociation in human pluripotent stem cells.
AB - A practical synthesis of the Rho-Kinase inhibitor Y-27632 and two new fluoro derivatives was achieved in seven steps and with a good overall yield of 45% starting from commercially available (R)-1-phenylethylamine. Compared to Y-27632 the new fluoro derivatives showed reduced or no effect on hPSC vitality and expansion after dissociation in human pluripotent stem cells.
UR - http://www.scopus.com/inward/record.url?scp=79960347518&partnerID=8YFLogxK
U2 - 10.1039/c1ob05332a
DO - 10.1039/c1ob05332a
M3 - Article
C2 - 21677986
AN - SCOPUS:79960347518
VL - 9
SP - 5503
EP - 5510
JO - Organic and Biomolecular Chemistry
JF - Organic and Biomolecular Chemistry
SN - 1477-0520
IS - 15
ER -