Details
| Original language | English |
|---|---|
| Pages (from-to) | 104-107 |
| Number of pages | 4 |
| Journal | Current Directions in Biomedical Engineering |
| Volume | 1 |
| Issue number | 1 |
| Publication status | Published - Sept 2015 |
Abstract
Electrospinning is a versatile method of producing micro- and nanofibers deposited in mats used as scaffolds for tissue engineering. Depending on the application, single or coaxial electrospinning can be used. Coaxial electrospinning enables the use of a broad spectrum of materials, the fabrication of hollow or core/shell fibers and an automatisation of the entire electrospinning process. In this regard, the design of coaxial nozzles plays a major role in a standardized as well as tailor-made scaffold fabrication. For this purpose an optimised coaxial nozzle has been designed and fabricated. Furthermore, tests have been carried out to validate the new nozzle design. With the use of the costum-made nozzle polymer concentration could be varied in a gradual manner. The variation in polymer concentration lead to fiber diameters between 0.75 to 3.25 μm. In addition, an increase in rotating velocity lead to an increase in fiber alignment as well as a slight decrease in fiber diameter. The demonstrated modifications of coaxial electrospinning proved to be a powerful tool for in-process adjustments of scaffold fabrication.
Keywords
- coaxial electrospinning, coaxial nozzle, in process adjustment, polycaprolactone, trifluorethanol
ASJC Scopus subject areas
- Engineering(all)
- Biomedical Engineering
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In: Current Directions in Biomedical Engineering, Vol. 1, No. 1, 09.2015, p. 104-107.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - A novel coaxial nozzle for in-process adjustment of electrospun scaffolds' fiber diameter Electrospun mats and their dependence on process parameters
AU - Becker, A.
AU - Zernetsch, H.
AU - Mueller, M.
AU - Glasmacher, B.
N1 - Publisher Copyright: © 2015 by Walter de Gruyter GmbH, Berlin/Boston 2015.
PY - 2015/9
Y1 - 2015/9
N2 - Electrospinning is a versatile method of producing micro- and nanofibers deposited in mats used as scaffolds for tissue engineering. Depending on the application, single or coaxial electrospinning can be used. Coaxial electrospinning enables the use of a broad spectrum of materials, the fabrication of hollow or core/shell fibers and an automatisation of the entire electrospinning process. In this regard, the design of coaxial nozzles plays a major role in a standardized as well as tailor-made scaffold fabrication. For this purpose an optimised coaxial nozzle has been designed and fabricated. Furthermore, tests have been carried out to validate the new nozzle design. With the use of the costum-made nozzle polymer concentration could be varied in a gradual manner. The variation in polymer concentration lead to fiber diameters between 0.75 to 3.25 μm. In addition, an increase in rotating velocity lead to an increase in fiber alignment as well as a slight decrease in fiber diameter. The demonstrated modifications of coaxial electrospinning proved to be a powerful tool for in-process adjustments of scaffold fabrication.
AB - Electrospinning is a versatile method of producing micro- and nanofibers deposited in mats used as scaffolds for tissue engineering. Depending on the application, single or coaxial electrospinning can be used. Coaxial electrospinning enables the use of a broad spectrum of materials, the fabrication of hollow or core/shell fibers and an automatisation of the entire electrospinning process. In this regard, the design of coaxial nozzles plays a major role in a standardized as well as tailor-made scaffold fabrication. For this purpose an optimised coaxial nozzle has been designed and fabricated. Furthermore, tests have been carried out to validate the new nozzle design. With the use of the costum-made nozzle polymer concentration could be varied in a gradual manner. The variation in polymer concentration lead to fiber diameters between 0.75 to 3.25 μm. In addition, an increase in rotating velocity lead to an increase in fiber alignment as well as a slight decrease in fiber diameter. The demonstrated modifications of coaxial electrospinning proved to be a powerful tool for in-process adjustments of scaffold fabrication.
KW - coaxial electrospinning
KW - coaxial nozzle
KW - in process adjustment
KW - polycaprolactone
KW - trifluorethanol
UR - http://www.scopus.com/inward/record.url?scp=85112016969&partnerID=8YFLogxK
U2 - 10.1515/cdbme-2015-0027
DO - 10.1515/cdbme-2015-0027
M3 - Article
AN - SCOPUS:85112016969
VL - 1
SP - 104
EP - 107
JO - Current Directions in Biomedical Engineering
JF - Current Directions in Biomedical Engineering
IS - 1
ER -