Details
| Original language | English |
|---|---|
| Pages (from-to) | 185-192 |
| Number of pages | 8 |
| Journal | Acta Biotechnologica |
| Volume | 16 |
| Issue number | 2-3 |
| Publication status | Published - 1996 |
Abstract
In this article, attention is focussed on an on-line sampling device for bioreactors and its characterization regarding sterility and response time. The integration of this device into analytical systems for biotechnology (FIA with biosensors) resulted in on-line analysis systems for bioprocess control. The new ESIP version of an in situ sampling system for bioprocess analysis produced by the EPPENDORF-NETHELER-HINZ GmbH, Germany, had a short response time of 8 min (99%), which was determined by means of conductivity measurement after an increase of the medium conductivity due to the gradual addition of KCl. Effectiveness and reliability of the module were tested by bubble point measurement resulting in a bubble point pressure of 2.1 bars. The sampling probe was tested successfully for use in a broad variety of microorganisms and cultivations.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Biotechnology
- Chemical Engineering(all)
- Bioengineering
- Immunology and Microbiology(all)
- Applied Microbiology and Biotechnology
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In: Acta Biotechnologica, Vol. 16, No. 2-3, 1996, p. 185-192.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - A New Version of an In situ Sampling System for Bioprocess Analysis
AU - Hilmer, J. M.
AU - Scheper, Th
PY - 1996
Y1 - 1996
N2 - In this article, attention is focussed on an on-line sampling device for bioreactors and its characterization regarding sterility and response time. The integration of this device into analytical systems for biotechnology (FIA with biosensors) resulted in on-line analysis systems for bioprocess control. The new ESIP version of an in situ sampling system for bioprocess analysis produced by the EPPENDORF-NETHELER-HINZ GmbH, Germany, had a short response time of 8 min (99%), which was determined by means of conductivity measurement after an increase of the medium conductivity due to the gradual addition of KCl. Effectiveness and reliability of the module were tested by bubble point measurement resulting in a bubble point pressure of 2.1 bars. The sampling probe was tested successfully for use in a broad variety of microorganisms and cultivations.
AB - In this article, attention is focussed on an on-line sampling device for bioreactors and its characterization regarding sterility and response time. The integration of this device into analytical systems for biotechnology (FIA with biosensors) resulted in on-line analysis systems for bioprocess control. The new ESIP version of an in situ sampling system for bioprocess analysis produced by the EPPENDORF-NETHELER-HINZ GmbH, Germany, had a short response time of 8 min (99%), which was determined by means of conductivity measurement after an increase of the medium conductivity due to the gradual addition of KCl. Effectiveness and reliability of the module were tested by bubble point measurement resulting in a bubble point pressure of 2.1 bars. The sampling probe was tested successfully for use in a broad variety of microorganisms and cultivations.
UR - http://www.scopus.com/inward/record.url?scp=0029852271&partnerID=8YFLogxK
U2 - 10.1002/abio.370160216
DO - 10.1002/abio.370160216
M3 - Article
AN - SCOPUS:0029852271
VL - 16
SP - 185
EP - 192
JO - Acta Biotechnologica
JF - Acta Biotechnologica
SN - 0138-4988
IS - 2-3
ER -