Details
| Original language | English |
|---|---|
| Pages (from-to) | 2004-2005 |
| Number of pages | 2 |
| Journal | Chemical communications |
| Volume | 2 |
| Issue number | 18 |
| Publication status | Published - 1 Jan 2002 |
| Externally published | Yes |
Abstract
A new, mild and high yielding synthesis of phosphoramidates is described: potassium salts of carboxylic acids are treated with ethylchloroformate and the resulting activated anhydride-carbonates are then treated with LiNHP(O)(OEt)2 in situ—the methodology is especially suited to acid sensitive systems featuring BOC,tBu or acetal protecting groups.
ASJC Scopus subject areas
- Chemical Engineering(all)
- Catalysis
- Materials Science(all)
- Electronic, Optical and Magnetic Materials
- Materials Science(all)
- Ceramics and Composites
- Chemistry(all)
- General Chemistry
- Materials Science(all)
- Surfaces, Coatings and Films
- Materials Science(all)
- Metals and Alloys
- Materials Science(all)
- Materials Chemistry
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In: Chemical communications, Vol. 2, No. 18, 01.01.2002, p. 2004-2005.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - A new synthesis of phosphoramidates
T2 - inhibitors of the key bacterial enzyme aspartate semi-aldehyde dehydrogenase
AU - Adams, Luke A.
AU - Cox, Russell J.
AU - Gibson, Jennifer S.
AU - Mayo-Martín, M. Belén
AU - Walter, Magnus
AU - Whittingham, William
PY - 2002/1/1
Y1 - 2002/1/1
N2 - A new, mild and high yielding synthesis of phosphoramidates is described: potassium salts of carboxylic acids are treated with ethylchloroformate and the resulting activated anhydride-carbonates are then treated with LiNHP(O)(OEt)2 in situ—the methodology is especially suited to acid sensitive systems featuring BOC,tBu or acetal protecting groups.
AB - A new, mild and high yielding synthesis of phosphoramidates is described: potassium salts of carboxylic acids are treated with ethylchloroformate and the resulting activated anhydride-carbonates are then treated with LiNHP(O)(OEt)2 in situ—the methodology is especially suited to acid sensitive systems featuring BOC,tBu or acetal protecting groups.
UR - http://www.scopus.com/inward/record.url?scp=0036400496&partnerID=8YFLogxK
U2 - 10.1039/b206199f
DO - 10.1039/b206199f
M3 - Article
C2 - 12357751
AN - SCOPUS:0036400496
VL - 2
SP - 2004
EP - 2005
JO - Chemical communications
JF - Chemical communications
SN - 1359-7345
IS - 18
ER -