Details
| Original language | English |
|---|---|
| Pages (from-to) | 1401-1403 |
| Number of pages | 3 |
| Journal | Tetrahedron Letters |
| Volume | 43 |
| Issue number | 8 |
| Publication status | Published - 3 Feb 2002 |
Abstract
New reagents for the high yielding amidination of primary and secondary amines are described. By attaching a benzyl substituent to the 3,5-dimethyl-1H-pyrazole-1-carboxamidine ring, a reagent 1 is obtained which allows easy work-up after amidination because of solubility of byproducts in organic solvents. In addition, the polystyrene-bound analogue 2 was prepared which allows amidination of various amines with high purity.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Pharmacology, Toxicology and Pharmaceutics(all)
- Drug Discovery
- Chemistry(all)
- Organic Chemistry
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In: Tetrahedron Letters, Vol. 43, No. 8, 03.02.2002, p. 1401-1403.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - A new reagent and its polymer-supported variant for the amidination of amines
AU - Dräger, Gerald
AU - Solodenko, Wladimir
AU - Messinger, Josef
AU - Schön, Uwe
AU - Kirschning, Andreas
N1 - Funding information: Financial support by the Fonds der Chemischen Industrie is gratefully acknowledged. Particularly, we thank Dr. W. Kehrbach (Solvay Pharmaceuticals GmbH, Hannover) for financial and technical support. Part of the project was made possible by the expert technical assistance of Dr. F. Tries.
PY - 2002/2/3
Y1 - 2002/2/3
N2 - New reagents for the high yielding amidination of primary and secondary amines are described. By attaching a benzyl substituent to the 3,5-dimethyl-1H-pyrazole-1-carboxamidine ring, a reagent 1 is obtained which allows easy work-up after amidination because of solubility of byproducts in organic solvents. In addition, the polystyrene-bound analogue 2 was prepared which allows amidination of various amines with high purity.
AB - New reagents for the high yielding amidination of primary and secondary amines are described. By attaching a benzyl substituent to the 3,5-dimethyl-1H-pyrazole-1-carboxamidine ring, a reagent 1 is obtained which allows easy work-up after amidination because of solubility of byproducts in organic solvents. In addition, the polystyrene-bound analogue 2 was prepared which allows amidination of various amines with high purity.
UR - http://www.scopus.com/inward/record.url?scp=0037127517&partnerID=8YFLogxK
U2 - 10.1016/S0040-4039(01)02403-0
DO - 10.1016/S0040-4039(01)02403-0
M3 - Article
AN - SCOPUS:0037127517
VL - 43
SP - 1401
EP - 1403
JO - Tetrahedron Letters
JF - Tetrahedron Letters
SN - 0040-4039
IS - 8
ER -