Details
| Original language | English |
|---|---|
| Pages (from-to) | 57-65 |
| Number of pages | 9 |
| Journal | Statistics in Biopharmaceutical Research |
| Volume | 4 |
| Issue number | 1 |
| Publication status | Published - 24 May 2012 |
Abstract
A modified Williams-type approach is proposed, which controls the family-wise error rate globally over both correlated endpoints and over dose comparisons. This order-restricted procedure is formulated for ratio-to-control comparisons, where the comparison of difference-to-control is included directly. Endpoint-specific variances are allowed, and even a modification for dose-group-specific variance heterogeneity is proposed. Therefore, this approach can be used simply for evaluation of real data by means of the R package SimComp. Both multiplicity-adjusted p-values and simultaneous confidence intervals are provided, whereas confidence intervals are clearly recommended to allow the interpretation for clinical relevance.
Keywords
- Correlated multiple endpoints, Trend test, Williams-type approach
ASJC Scopus subject areas
- Mathematics(all)
- Statistics and Probability
- Pharmacology, Toxicology and Pharmaceutics(all)
- Pharmaceutical Science
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In: Statistics in Biopharmaceutical Research, Vol. 4, No. 1, 24.05.2012, p. 57-65.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - A Multivariate Williams-Type Trend Procedure
AU - Hasler, Mario
AU - Hothorn, Ludwig A.
PY - 2012/5/24
Y1 - 2012/5/24
N2 - A modified Williams-type approach is proposed, which controls the family-wise error rate globally over both correlated endpoints and over dose comparisons. This order-restricted procedure is formulated for ratio-to-control comparisons, where the comparison of difference-to-control is included directly. Endpoint-specific variances are allowed, and even a modification for dose-group-specific variance heterogeneity is proposed. Therefore, this approach can be used simply for evaluation of real data by means of the R package SimComp. Both multiplicity-adjusted p-values and simultaneous confidence intervals are provided, whereas confidence intervals are clearly recommended to allow the interpretation for clinical relevance.
AB - A modified Williams-type approach is proposed, which controls the family-wise error rate globally over both correlated endpoints and over dose comparisons. This order-restricted procedure is formulated for ratio-to-control comparisons, where the comparison of difference-to-control is included directly. Endpoint-specific variances are allowed, and even a modification for dose-group-specific variance heterogeneity is proposed. Therefore, this approach can be used simply for evaluation of real data by means of the R package SimComp. Both multiplicity-adjusted p-values and simultaneous confidence intervals are provided, whereas confidence intervals are clearly recommended to allow the interpretation for clinical relevance.
KW - Correlated multiple endpoints
KW - Trend test
KW - Williams-type approach
UR - http://www.scopus.com/inward/record.url?scp=84865051053&partnerID=8YFLogxK
U2 - 10.1080/19466315.2011.633868
DO - 10.1080/19466315.2011.633868
M3 - Article
AN - SCOPUS:84865051053
VL - 4
SP - 57
EP - 65
JO - Statistics in Biopharmaceutical Research
JF - Statistics in Biopharmaceutical Research
SN - 1946-6315
IS - 1
ER -