Details
| Original language | English |
|---|---|
| Pages (from-to) | 2370-2374 |
| Number of pages | 5 |
| Journal | Organic letters |
| Volume | 23 |
| Issue number | 6 |
| Early online date | 10 Mar 2021 |
| Publication status | Published - 19 Mar 2021 |
| Externally published | Yes |
Abstract
A modular flow platform for natural product synthesis was designed. To access different reaction setups with a maximum of flexibility, interchangeable 3D-printed components serve as backbone. By switching from liquid- to gas-driven flow, reagent and solvent waste is minimized, which translates into an advantageous sustainability profile. To enable inert conditions, "Schlenk-in-flow"techniques for the safe handling of oxygen- and moisture sensitive reagents were developed. Adopting these techniques, reproducible transformations in natural product synthesis were achieved.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Chemistry(all)
- Physical and Theoretical Chemistry
- Chemistry(all)
- Organic Chemistry
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In: Organic letters, Vol. 23, No. 6, 19.03.2021, p. 2370-2374.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - A Modular, Argon-Driven Flow Platform for Natural Product Synthesis and Late-Stage Transformations
AU - Kleoff, Merlin
AU - Schwan, Johannes
AU - Christmann, Mathias
AU - Heretsch, Philipp
N1 - Funding information: This work was funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) ? 452127669 and Boehringer Ingelheim Stiftung (Plus 3 Perspectives Programme to PH). We are grateful to Prof. Kerry Gilmore (University of Connecticut) and Dr. Simon Steinhauer (Freie Universität Berlin) for helpful discussions and to Dr. Thomas Siemon, Dr. Franziska Reuß, and Lisa Boeser (all Freie Universitat Berlin) for preparative support. We acknowledge the assistance of the Core Facility BioSupraMol supported by the DFG. This work was funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) – 452127669 and Boehringer Ingelheim Stiftung (Plus 3 Perspectives Programme to PH). We are grateful to Prof. Kerry Gilmore (University of Connecticut) and Dr. Simon Steinhauer (Freie Universität Berlin) for helpful discussions and to Dr. Thomas Siemon, Dr. Franziska Reuß, and Lisa Boeser (all Freie Universität Berlin) for preparative support. We acknowledge the assistance of the Core Facility BioSupraMol supported by the DFG.
PY - 2021/3/19
Y1 - 2021/3/19
N2 - A modular flow platform for natural product synthesis was designed. To access different reaction setups with a maximum of flexibility, interchangeable 3D-printed components serve as backbone. By switching from liquid- to gas-driven flow, reagent and solvent waste is minimized, which translates into an advantageous sustainability profile. To enable inert conditions, "Schlenk-in-flow"techniques for the safe handling of oxygen- and moisture sensitive reagents were developed. Adopting these techniques, reproducible transformations in natural product synthesis were achieved.
AB - A modular flow platform for natural product synthesis was designed. To access different reaction setups with a maximum of flexibility, interchangeable 3D-printed components serve as backbone. By switching from liquid- to gas-driven flow, reagent and solvent waste is minimized, which translates into an advantageous sustainability profile. To enable inert conditions, "Schlenk-in-flow"techniques for the safe handling of oxygen- and moisture sensitive reagents were developed. Adopting these techniques, reproducible transformations in natural product synthesis were achieved.
UR - http://www.scopus.com/inward/record.url?scp=85103228877&partnerID=8YFLogxK
U2 - 10.1021/acs.orglett.1c00661
DO - 10.1021/acs.orglett.1c00661
M3 - Article
VL - 23
SP - 2370
EP - 2374
JO - Organic letters
JF - Organic letters
SN - 1523-7060
IS - 6
ER -