Details
| Original language | English |
|---|---|
| Pages (from-to) | 120-132 |
| Number of pages | 13 |
| Journal | International Journal for Vitamin and Nutrition Research |
| Volume | 94 |
| Issue number | 2 |
| Early online date | 30 Jan 2023 |
| Publication status | Published - 1 Apr 2024 |
Abstract
Elevated homocysteine (Hcy) levels (≥15 μmol/L) in the elderly are frequently associated with a higher risk of cardiovascular disease and cognitive decline. Several studies have already shown an Hcy-lowering effect of B vitamin supplementation in cohorts deficient in these nutrients. The aim of this randomized, double-blinded 12-week intervention study was to investigate whether Hcy levels in healthy elderly subjects (75.4±4.5 years, n=133) could be lowered with a micronutrient supplement (i.e., 400 μg folic acid, 100 μg cobalamin). Difference in mean initial Hcy levels between intervention (17.6±7.1 μmol/L, n=65) and placebo group (18.9±6.1 μmol/L, n=68) was not significant. The prevalence of cobalamin and folate deficiency in the total study population was low: 27% had serum-cobalamin levels ≤150 pmol/L, 12% holo-transcobalamin (Holo-TC) levels ≤50 pmol/L, 13% low cobalamin status using the aggregated cobalamin marker 4cB12 and 10% red blood cell (RBC) folate ≤570 nmol/L. Nevertheless, the treated subjects still showed improved cobalamin and folate biostatus (serum cobalamin Δt 12-t 0: 63±48 pmol/L; Holo-TC Δt 12-t 0: 17±19 pmol/L; RBC folate Δt 12-t 0: 326±253 nmol/L) and Hcy levels (Δt 12-t 0: -3.6±5.7 μmol/L). The effects were statistically significant compared to the placebo group with p=0.005 (serum cobalamin), p=0.021 (Holo-TC), p=0.014 (RBC-folate) and p<0.001 (Hcy). The Hcy-lowering effect was dependent on the initial Hcy levels (p<0.001). Our findings suggest that elevated Hcy levels in elderly subjects can be lowered regardless of the initial cobalamin and folate biostatus.
Keywords
- folate, homocysteine, hyperhomocysteinemia, multivitamin, vitamin B12
ASJC Scopus subject areas
- Nursing(all)
- Nutrition and Dietetics
- Medicine(all)
- Medicine (miscellaneous)
- Medicine(all)
- Endocrinology, Diabetes and Metabolism
Sustainable Development Goals
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In: International Journal for Vitamin and Nutrition Research, Vol. 94, No. 2, 01.04.2024, p. 120-132.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - A micronutrient supplement modulates homocysteine levels regardless of vitamin B biostatus in elderly subjects
AU - Savic-Hartwig, Marija
AU - Kerlikowsky, Felix
AU - van de Flierdt, Edda
AU - Hahn, Andreas
AU - Schuchardt, Jan Philipp
N1 - Funding Information: This research was partially funded by the Food Federation, Germany, Claire-Waldoff-Straße 7, 10117, Berlin. The authors declare that they have no competing interests. The authors are solely responsible for the design and implementation of the study and collection, management, analysis, and interpretation of the data, as well as preparation of the manuscript.
PY - 2024/4/1
Y1 - 2024/4/1
N2 - Elevated homocysteine (Hcy) levels (≥15 μmol/L) in the elderly are frequently associated with a higher risk of cardiovascular disease and cognitive decline. Several studies have already shown an Hcy-lowering effect of B vitamin supplementation in cohorts deficient in these nutrients. The aim of this randomized, double-blinded 12-week intervention study was to investigate whether Hcy levels in healthy elderly subjects (75.4±4.5 years, n=133) could be lowered with a micronutrient supplement (i.e., 400 μg folic acid, 100 μg cobalamin). Difference in mean initial Hcy levels between intervention (17.6±7.1 μmol/L, n=65) and placebo group (18.9±6.1 μmol/L, n=68) was not significant. The prevalence of cobalamin and folate deficiency in the total study population was low: 27% had serum-cobalamin levels ≤150 pmol/L, 12% holo-transcobalamin (Holo-TC) levels ≤50 pmol/L, 13% low cobalamin status using the aggregated cobalamin marker 4cB12 and 10% red blood cell (RBC) folate ≤570 nmol/L. Nevertheless, the treated subjects still showed improved cobalamin and folate biostatus (serum cobalamin Δt 12-t 0: 63±48 pmol/L; Holo-TC Δt 12-t 0: 17±19 pmol/L; RBC folate Δt 12-t 0: 326±253 nmol/L) and Hcy levels (Δt 12-t 0: -3.6±5.7 μmol/L). The effects were statistically significant compared to the placebo group with p=0.005 (serum cobalamin), p=0.021 (Holo-TC), p=0.014 (RBC-folate) and p<0.001 (Hcy). The Hcy-lowering effect was dependent on the initial Hcy levels (p<0.001). Our findings suggest that elevated Hcy levels in elderly subjects can be lowered regardless of the initial cobalamin and folate biostatus.
AB - Elevated homocysteine (Hcy) levels (≥15 μmol/L) in the elderly are frequently associated with a higher risk of cardiovascular disease and cognitive decline. Several studies have already shown an Hcy-lowering effect of B vitamin supplementation in cohorts deficient in these nutrients. The aim of this randomized, double-blinded 12-week intervention study was to investigate whether Hcy levels in healthy elderly subjects (75.4±4.5 years, n=133) could be lowered with a micronutrient supplement (i.e., 400 μg folic acid, 100 μg cobalamin). Difference in mean initial Hcy levels between intervention (17.6±7.1 μmol/L, n=65) and placebo group (18.9±6.1 μmol/L, n=68) was not significant. The prevalence of cobalamin and folate deficiency in the total study population was low: 27% had serum-cobalamin levels ≤150 pmol/L, 12% holo-transcobalamin (Holo-TC) levels ≤50 pmol/L, 13% low cobalamin status using the aggregated cobalamin marker 4cB12 and 10% red blood cell (RBC) folate ≤570 nmol/L. Nevertheless, the treated subjects still showed improved cobalamin and folate biostatus (serum cobalamin Δt 12-t 0: 63±48 pmol/L; Holo-TC Δt 12-t 0: 17±19 pmol/L; RBC folate Δt 12-t 0: 326±253 nmol/L) and Hcy levels (Δt 12-t 0: -3.6±5.7 μmol/L). The effects were statistically significant compared to the placebo group with p=0.005 (serum cobalamin), p=0.021 (Holo-TC), p=0.014 (RBC-folate) and p<0.001 (Hcy). The Hcy-lowering effect was dependent on the initial Hcy levels (p<0.001). Our findings suggest that elevated Hcy levels in elderly subjects can be lowered regardless of the initial cobalamin and folate biostatus.
KW - folate
KW - homocysteine
KW - hyperhomocysteinemia
KW - multivitamin
KW - vitamin B12
UR - http://www.scopus.com/inward/record.url?scp=85147350007&partnerID=8YFLogxK
U2 - 10.1024/0300-9831/a000777
DO - 10.1024/0300-9831/a000777
M3 - Article
C2 - 36715360
VL - 94
SP - 120
EP - 132
JO - International Journal for Vitamin and Nutrition Research
JF - International Journal for Vitamin and Nutrition Research
SN - 0300-9831
IS - 2
ER -