Details
| Original language | English |
|---|---|
| Title of host publication | Biomedical Technology |
| Editors | Thomas Lenarz, Peter Wriggers |
| Pages | 41-53 |
| Number of pages | 13 |
| ISBN (electronic) | 978-3-319-10981-7 |
| Publication status | Published - 2015 |
Publication series
| Name | Lecture Notes in Applied and Computational Mechanics |
|---|---|
| Publisher | Springer Verlag |
| Volume | 74 |
| ISSN (Print) | 1613-7736 |
Abstract
In this work a biochemical fracture healing model coupled with mechanical stimulation of stem cell differentiation is investigated. A finite element scheme is applied to the underlaying advection-diffusion-reaction problem, using the Time Discontinuous Galerkin and Finite Calculus method to ensure stability of the calculation. Strains within the callus region are computed and used for a characterization of the local mechanical demand and the resulting stimulation of the healing process. A theoretical axisymmetric model of a sheep osteotomy is implemented and results of the presented FEM approach are discussed. The repair progresswill be determined by the interfragmentary movement (IFM) and the mean tissue densities.
Keywords
- Biomechanics, Bone repair, Finite element, Fracture healing
ASJC Scopus subject areas
- Engineering(all)
- Mechanical Engineering
- Computer Science(all)
- Computational Theory and Mathematics
Cite this
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Biomedical Technology. ed. / Thomas Lenarz; Peter Wriggers. 2015. p. 41-53 (Lecture Notes in Applied and Computational Mechanics; Vol. 74).
Research output: Chapter in book/report/conference proceeding › Contribution to book/anthology › Research › peer review
}
TY - CHAP
T1 - A mechanically stimulated fracture healing model using a finite element framework
AU - Sapotnick, Alexander
AU - Nackenhorst, Udo
N1 - Funding Information: This research was founded by the German Research Foundation (Deutsche Forschungsgemeinschaft Na330/8-1).
PY - 2015
Y1 - 2015
N2 - In this work a biochemical fracture healing model coupled with mechanical stimulation of stem cell differentiation is investigated. A finite element scheme is applied to the underlaying advection-diffusion-reaction problem, using the Time Discontinuous Galerkin and Finite Calculus method to ensure stability of the calculation. Strains within the callus region are computed and used for a characterization of the local mechanical demand and the resulting stimulation of the healing process. A theoretical axisymmetric model of a sheep osteotomy is implemented and results of the presented FEM approach are discussed. The repair progresswill be determined by the interfragmentary movement (IFM) and the mean tissue densities.
AB - In this work a biochemical fracture healing model coupled with mechanical stimulation of stem cell differentiation is investigated. A finite element scheme is applied to the underlaying advection-diffusion-reaction problem, using the Time Discontinuous Galerkin and Finite Calculus method to ensure stability of the calculation. Strains within the callus region are computed and used for a characterization of the local mechanical demand and the resulting stimulation of the healing process. A theoretical axisymmetric model of a sheep osteotomy is implemented and results of the presented FEM approach are discussed. The repair progresswill be determined by the interfragmentary movement (IFM) and the mean tissue densities.
KW - Biomechanics
KW - Bone repair
KW - Finite element
KW - Fracture healing
UR - http://www.scopus.com/inward/record.url?scp=84921651649&partnerID=8YFLogxK
U2 - 10.1007/978-3-319-10981-7_3
DO - 10.1007/978-3-319-10981-7_3
M3 - Contribution to book/anthology
AN - SCOPUS:84921651649
SN - 978-3-319-10980-0
SN - 978-3-319-36020-1
T3 - Lecture Notes in Applied and Computational Mechanics
SP - 41
EP - 53
BT - Biomedical Technology
A2 - Lenarz, Thomas
A2 - Wriggers, Peter
ER -