A general framework for the evaluation of genetic association studies using multiple marginal models

Research output: Contribution to journalArticleResearchpeer review

Authors

  • Andreas Kitsche
  • Christian Ritz
  • Ludwig A. Hothorn

Research Organisations

External Research Organisations

  • University of Copenhagen
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Details

Original languageEnglish
Pages (from-to)150-172
Number of pages23
JournalHuman heredity
Volume81
Issue number3
Publication statusPublished - 22 Dec 2016

Abstract

Objective: In this study, we present a simultaneous inference procedure as a unified analysis framework for genetic association studies. Methods: The method is based on the formulation of multiple marginal models that reflect different modes of inheritance. The basic advantage of this methodology is that no explicit formulation of the correlation between the test statistics is required. Moreover, the genotype scores are considered as a quantitative explanatory variable, i.e., regression models are used. Results: The proposed approach covers a wide variety of endpoints (binary, count, quantitative, and time-to-event data). In addition, multiple endpoints of different types can be assessed simultaneously. This allows the detection of pleiotropic effects while taking the mode of inheritance into account. Moreover, multiple loci can be assessed simultaneously. Conclusion: The flexibility of the proposed approach is demonstrated while analyzing a variety of data examples.

Keywords

    Generalized linear models, Genetic association, Pleiotropy, Simultaneous inference

ASJC Scopus subject areas

Cite this

A general framework for the evaluation of genetic association studies using multiple marginal models. / Kitsche, Andreas; Ritz, Christian; Hothorn, Ludwig A.
In: Human heredity, Vol. 81, No. 3, 22.12.2016, p. 150-172.

Research output: Contribution to journalArticleResearchpeer review

Kitsche A, Ritz C, Hothorn LA. A general framework for the evaluation of genetic association studies using multiple marginal models. Human heredity. 2016 Dec 22;81(3):150-172. doi: 10.1159/000448477
Kitsche, Andreas ; Ritz, Christian ; Hothorn, Ludwig A. / A general framework for the evaluation of genetic association studies using multiple marginal models. In: Human heredity. 2016 ; Vol. 81, No. 3. pp. 150-172.
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