Details
| Original language | English |
|---|---|
| Pages (from-to) | 744-759 |
| Number of pages | 16 |
| Journal | Engineering in life sciences |
| Volume | 22 |
| Issue number | 12 |
| Publication status | Published - 8 Dec 2022 |
Abstract
Since its invention in the 1980s, 3D printing has evolved into a versatile technique for the additive manufacturing of diverse objects and tools, using various materials. The relative flexibility, straightforwardness, and ability to enable rapid prototyping are tremendous advantages offered by this technique compared to conventional methods for miniaturized and microfluidic systems fabrication (such as soft lithography). The development of 3D printers exhibiting high printer resolution has enabled the fabrication of accurate miniaturized and microfluidic systems—which have, in turn, substantially reduced both device sizes and required sample volumes. Moreover, the continuing development of translucent, heat resistant, and biocompatible materials will make 3D printing more and more useful for applications in biotechnology in the coming years. Today, a wide variety of 3D-printed objects in biotechnology—ranging from miniaturized cultivation chambers to microfluidic lab-on-a-chip devices for diagnostics—are already being deployed in labs across the world. This review explains the 3D printing technologies that are currently used to fabricate such miniaturized microfluidic devices, and also seeks to offer some insight into recent developments demonstrating the use of these tools for biotechnological applications such as cell culture, separation techniques, and biosensors.
Keywords
- 3D printing, biosensors, cell culture, microfluidics, miniaturization
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Biotechnology
- Chemical Engineering(all)
- Bioengineering
- Environmental Science(all)
- Environmental Engineering
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In: Engineering in life sciences, Vol. 22, No. 12, 08.12.2022, p. 744-759.
Research output: Contribution to journal › Review article › Research › peer review
}
TY - JOUR
T1 - 3D printing in biotechnology
T2 - An insight into miniaturized and microfluidic systems for applications from cell culture to bioanalytics
AU - Heuer, Christopher
AU - Preuß, John Alexander
AU - Habib, Taieb
AU - Enders, Anton
AU - Bahnemann, Janina
N1 - Funding information: The authors acknowledge the financial support through the Emmy Noether Programme (346772917).
PY - 2022/12/8
Y1 - 2022/12/8
N2 - Since its invention in the 1980s, 3D printing has evolved into a versatile technique for the additive manufacturing of diverse objects and tools, using various materials. The relative flexibility, straightforwardness, and ability to enable rapid prototyping are tremendous advantages offered by this technique compared to conventional methods for miniaturized and microfluidic systems fabrication (such as soft lithography). The development of 3D printers exhibiting high printer resolution has enabled the fabrication of accurate miniaturized and microfluidic systems—which have, in turn, substantially reduced both device sizes and required sample volumes. Moreover, the continuing development of translucent, heat resistant, and biocompatible materials will make 3D printing more and more useful for applications in biotechnology in the coming years. Today, a wide variety of 3D-printed objects in biotechnology—ranging from miniaturized cultivation chambers to microfluidic lab-on-a-chip devices for diagnostics—are already being deployed in labs across the world. This review explains the 3D printing technologies that are currently used to fabricate such miniaturized microfluidic devices, and also seeks to offer some insight into recent developments demonstrating the use of these tools for biotechnological applications such as cell culture, separation techniques, and biosensors.
AB - Since its invention in the 1980s, 3D printing has evolved into a versatile technique for the additive manufacturing of diverse objects and tools, using various materials. The relative flexibility, straightforwardness, and ability to enable rapid prototyping are tremendous advantages offered by this technique compared to conventional methods for miniaturized and microfluidic systems fabrication (such as soft lithography). The development of 3D printers exhibiting high printer resolution has enabled the fabrication of accurate miniaturized and microfluidic systems—which have, in turn, substantially reduced both device sizes and required sample volumes. Moreover, the continuing development of translucent, heat resistant, and biocompatible materials will make 3D printing more and more useful for applications in biotechnology in the coming years. Today, a wide variety of 3D-printed objects in biotechnology—ranging from miniaturized cultivation chambers to microfluidic lab-on-a-chip devices for diagnostics—are already being deployed in labs across the world. This review explains the 3D printing technologies that are currently used to fabricate such miniaturized microfluidic devices, and also seeks to offer some insight into recent developments demonstrating the use of these tools for biotechnological applications such as cell culture, separation techniques, and biosensors.
KW - 3D printing
KW - biosensors
KW - cell culture
KW - microfluidics
KW - miniaturization
UR - http://www.scopus.com/inward/record.url?scp=85118533010&partnerID=8YFLogxK
U2 - 10.1002/elsc.202100081
DO - 10.1002/elsc.202100081
M3 - Review article
AN - SCOPUS:85118533010
VL - 22
SP - 744
EP - 759
JO - Engineering in life sciences
JF - Engineering in life sciences
SN - 1618-0240
IS - 12
ER -