Details
| Original language | English |
|---|---|
| Pages (from-to) | 37-52 |
| Number of pages | 16 |
| Journal | MRS communications |
| Volume | 9 |
| Issue number | 1 |
| Early online date | 25 Sept 2018 |
| Publication status | Published - 15 Mar 2019 |
| Externally published | Yes |
Abstract
The complex interaction between hematopoietic stem cells (HSCs) and their microenvironment in the human bone marrow ensures a life-long blood production by balancing stem cell maintenance and differentiation. This so-called HSC niche can be disturbed by malignant diseases. Investigating their consequences on hematopoiesis requires a deep understanding of how the niches function in health and disease. To facilitate this, biomimetic models of the bone marrow are needed to analyze HSC maintenance and hematopoiesis under steady state and diseased conditions. Here, 3D bone marrow models, their fabrication methods (including 3D bioprinting), and implementations recapturing bone marrow functions in health and diseases are presented.
ASJC Scopus subject areas
Sustainable Development Goals
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In: MRS communications, Vol. 9, No. 1, 15.03.2019, p. 37-52.
Research output: Contribution to journal › Article › Research › peer review
}
TY - JOUR
T1 - 3D models of the bone marrow in health and disease
T2 - yesterday, today, and tomorrow
AU - Raic, Annamarija
AU - Naolou, Toufik
AU - Mohra, Anna
AU - Chatterjee, Chandralekha
AU - Lee-Thedieck, Cornelia
N1 - © Materials Research Society, 2018
PY - 2019/3/15
Y1 - 2019/3/15
N2 - The complex interaction between hematopoietic stem cells (HSCs) and their microenvironment in the human bone marrow ensures a life-long blood production by balancing stem cell maintenance and differentiation. This so-called HSC niche can be disturbed by malignant diseases. Investigating their consequences on hematopoiesis requires a deep understanding of how the niches function in health and disease. To facilitate this, biomimetic models of the bone marrow are needed to analyze HSC maintenance and hematopoiesis under steady state and diseased conditions. Here, 3D bone marrow models, their fabrication methods (including 3D bioprinting), and implementations recapturing bone marrow functions in health and diseases are presented.
AB - The complex interaction between hematopoietic stem cells (HSCs) and their microenvironment in the human bone marrow ensures a life-long blood production by balancing stem cell maintenance and differentiation. This so-called HSC niche can be disturbed by malignant diseases. Investigating their consequences on hematopoiesis requires a deep understanding of how the niches function in health and disease. To facilitate this, biomimetic models of the bone marrow are needed to analyze HSC maintenance and hematopoiesis under steady state and diseased conditions. Here, 3D bone marrow models, their fabrication methods (including 3D bioprinting), and implementations recapturing bone marrow functions in health and diseases are presented.
UR - http://www.scopus.com/inward/record.url?scp=85054959493&partnerID=8YFLogxK
U2 - 10.1557/mrc.2018.203
DO - 10.1557/mrc.2018.203
M3 - Article
C2 - 30931174
VL - 9
SP - 37
EP - 52
JO - MRS communications
JF - MRS communications
SN - 2159-6859
IS - 1
ER -