13C Labeling reveals multiple amination reactions in the biosynthesis of a novel polyketide polyamine antibiotic zeamine from Dickeya zeae

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Authors

  • Jien Wu
  • Hai Bao Zhang
  • Jin Ling Xu
  • Russell J. Cox
  • Thomas J. Simpson
  • Lian Hui Zhang

External Research Organisations

  • A-STAR
  • University of Bristol
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Details

Original languageEnglish
Pages (from-to)333-335
Number of pages3
JournalChemical communications
Volume46
Issue number2
Publication statusPublished - 2010
Externally publishedYes

Abstract

The structure of zeamine, a novel polyamino-amide antibiotic metabolite of Dickeya zeae has been established by NMR and detailed MS analyses; labelling studies with 13C-labelled acetates suggest that the repeating secondary amine containing motif may be biosynthesised via a modular PKS containing aminotransferase domains.

ASJC Scopus subject areas

Cite this

13C Labeling reveals multiple amination reactions in the biosynthesis of a novel polyketide polyamine antibiotic zeamine from Dickeya zeae. / Wu, Jien; Zhang, Hai Bao; Xu, Jin Ling et al.
In: Chemical communications, Vol. 46, No. 2, 2010, p. 333-335.

Research output: Contribution to journalArticleResearchpeer review

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abstract = "The structure of zeamine, a novel polyamino-amide antibiotic metabolite of Dickeya zeae has been established by NMR and detailed MS analyses; labelling studies with 13C-labelled acetates suggest that the repeating secondary amine containing motif may be biosynthesised via a modular PKS containing aminotransferase domains.",
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