Structure-Based Optimization of Pyridone α-Ketoamides as Inhibitors of the SARS-CoV-2 Main Protease

Akula, R. K., El Kilani, H., Metzen, A., Röske, J., Zhang, K., Göhl, M., Arisetti, N., Marsh, G. P., Maple, H. J., Cooper, M. S., Karadogan, B., Jochmans, D., Neyts, J., Rox, K., Hilgenfeld, R. & Brönstrup, M., 13 Feb 2025, In: Journal of medicinal chemistry. 68, 3, p. 2920–2941 22 p.

Research output: Contribution to journal › Article › Research › peer review

Antibacterials with Novel Chemical Scaffolds in Clinical Development

Heimann, D., Kohnhäuser, D., Kohnhäuser, A. J. & Brönstrup, M., 23 Jan 2025, (E-pub ahead of print) In: DRUGS. 31 p., 115484.

Research output: Contribution to journal › Article › Research › peer review

Cytotoxic and proliferation-inhibitory activity of natural and synthetic fungal tropolone sesquiterpenoids in various cell lines

Bergmann, T. C., Menssen, M., Schotte, C., Cox, R. J. & Lee-Thedieck, C., 30 Nov 2024, In: Heliyon. 10, 22, e37713.

Research output: Contribution to journal › Article › Research › peer review

Inceptor binds to and directs insulin towards lysosomal degradation in β cells

Siehler, J., Bilekova, S., Chapouton, P., Dema, A., Albanese, P., Tamara, S., Jain, C., Sterr, M., Enos, S. J., Chen, C., Malhotra, C., Villalba, A., Schomann, L., Bhattacharya, S., Feng, J., Akgün Canan, M., Ribaudo, F., Ansarullah, Burtscher, I., Ahlbrecht, C., Plettenburg, O., Kurth, T., Scharfmann, R., Speier, S., Scheltema, R. A. & Lickert, H., 25 Nov 2024, In: Nature Metabolism. 6, 12, p. 2374-2390 17 p., e202206132.

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A Targeted Click-to-Release Activation of the Last-Resort Antibiotic Colistin Reduces its Renal Cell Toxicity

Charoenpattarapreeda, J., Tegge, W., Xu, C., Harmrolfs, K., Hinkelmann, B., Wullenkord, H., Hotop, S. K., Beutling, U., Rox, K. & Brönstrup, M., 11 Nov 2024, In: Angewandte Chemie - International Edition. 63, 47, 8 p., e202408360.

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Synthetic studies on the tetrasubstituted D-ring of cystobactamids lead to potent terephthalic acid antibiotics

Stappert, M., Kohnhäuser, D., Seedorf, T., Coetzee, J., Rox, K., Fuchs, H. L. S., Cirnski, K., Leitner, C., Herrmann, J., Kirschning, A., Müller, R. & Brönstrup, M., 5 Nov 2024, In: Communications Chemistry. 7, 1, 252.

Research output: Contribution to journal › Article › Research › peer review

Optimization of the Central α-Amino Acid in Cystobactamids to the Broad-Spectrum, Resistance-Breaking Antibiotic CN-CC-861

Kohnhäuser, D., Seedorf, T., Cirnski, K., Heimann, D., Coetzee, J., Sordello, S., Richter, J., Stappert, M., Sabuco, J. F., Corbett, D., Bacque, E., Rox, K., Herrmann, J., Vassort, A., Muller, R., Kirschning, A. & Bronstrup, M., 10 Oct 2024, In: Journal of medicinal chemistry. 67, 19, p. 17162-17190 29 p.

Research output: Contribution to journal › Article › Research › peer review

Introducing co-review to RSC Advances

Fisher, L., Cox, R. J. & Faulds, K., 1 Oct 2024, In: RSC Advances. 14, 42, p. 30955-30956 2 p.

Research output: Contribution to journal › Editorial in journal › Research › peer review

Chemical tools for unpicking plant specialised metabolic pathways

Seligmann, B., Liu, S. & Franke, J., Aug 2024, In: Current opinion in plant biology. 80, 8 p., 102554.

Research output: Contribution to journal › Review article › Research › peer review

Tuning the photophysical properties of cyanine by barbiturate functionalization and nanoformulation for efficient optoacoustics- guided phototherapy

Liu, N., O'Connor, P., Gujrati, V., Shelar, D., Ma, X., Anzenhofer, P., Klemm, U., Su, X., Huang, Y., Kleigrewe, K., Feuchtinger, A., Walch, A., Sattler, M., Plettenburg, O. & Ntziachristos, V., Aug 2024, In: Journal of controlled release. 372, p. 522-530 9 p.

Research output: Contribution to journal › Article › Research › peer review

Outstanding Reviewers for RSC Advances in 2023

Alonso, G., Bacha, A. U. R., Biswas, S., Campana, F., Crawford, S., Ding, C., Ding, S., Figueira, F., Gill, F., Kordić, B., Liu, X., Matos, P. M., Maturi, M., Nkanga, C., Wang, C., Wang, L., Yan, H., Yin, Y., Yuan, K., Zhang, B., Zhou, Y., Zhu, Y., Bhattacharyya, S., Bracamonte, A., Cai, W., Chourey, S., Fahmy, S., Kalmode, H., Kasprzak, A., Kumar, S. G., Kuwahara, S., Li, F., Li, H., Li, J. M., Li, Y., Lindner, E., Matusiak, J., Nikolic, M. V., Pajerski, W., Sahu, A., Sarkar, A., Sheehan, J., Urgunde, A. B., Vargas-Bernal, R., Wang, L., Yamamoto, M., Fisher, L. (Contributor), Faulds, K. (Contributor) & Cox, R. J. (Contributor), 1 Jul 2024, In: RSC Advances. 14, 29, p. 20797-20798 2 p.

Research output: Contribution to journal › Editorial in journal › Research › peer review

Fabrication of a low-cost benchtop optical imager for quantum dot microarray-based stress biomarker detection

Kishore, A., Varughese, A. M., Roth, B. & Zeilinger, C., 7 Jun 2024, In: Biomedical optics express. 15, 7, p. 4147-4161 15 p.

Research output: Contribution to journal › Article › Research › peer review

Activity-Based Protein Profiling Identifies Protein Disulfide-Isomerases as Target Proteins of the Volatile Salinilactones

Jerye, K., Lüken, H., Steffen, A., Schlawis, C., Jänsch, L., Schulz, S. & Brönstrup, M., 15 May 2024, In: Advanced science. 11, 18, 11 p., 2309515.

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Is Simultaneous Binding to DNA and Gyrase Important for the Antibacterial Activity of Cystobactamids?

Solga, D., Wieske, L. H. E., Wilcox, S., Zeilinger, C., Jansen-Olliges, L., Cirnski, K., Herrmann, J., Müller, R., Erdelyi, M. & Kirschning, A., 5 Apr 2024, In: Chemistry - a European journal. 30, 19, 14 p., e202303796.

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Biosynthesis of the allelopathic alkaloid gramine in barley by a cryptic oxidative rearrangement

Leite Dias, S., Chuang, L., Liu, S., Seligmann, B., Brendel, F. L., Gabriel Chavez, B., Hoffie, R. E., Hoffie, I., Kumlehn, J., Bültemeier, A., Wolf, J., Herde, M., Witte, C. P., D’Auria, J. C. & Franke, J., 29 Mar 2024, In: SCIENCE. 383, 6690, p. 1448-1454 7 p.

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Reductive Release from a Hybrid PKS-NRPS during the Biosynthesis of Pyrichalasin H

Heinemann, H., Zhang, H. & Cox, R. J., 16 Jan 2024, In: Chemistry - a European journal. 30, 4, 8 p., e202302590.

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Engineered and total biosynthesis of fungal specialized metabolites

Cox, R. J., Jan 2024, In: Nature Reviews Chemistry. 8, 1, p. 61–78 18 p.

Research output: Contribution to journal › Review article › Research › peer review

Investigation of chain-length selection by the tenellin iterative highly-reducing polyketide synthase

Schmidt, K. & Cox, R. J., 2024, In: RSC Advances. 14, 13, p. 8963-8970 8 p.

Research output: Contribution to journal › Article › Research › peer review

Unraveling intragenomic polymorphisms in the high-quality genome of Hypoxylaceae: a comprehensive study of the rDNA cistron

Cedeño-Sanchez, M., Cheng, T., Lambert, C., Kolarík, M., Kuhnert, E., Cox, R. J., Kalinowski, J., Verwaaijen, B. & Stadler, M., 2024, In: Mycological progress. 23, 1, 5.

Research output: Contribution to journal › Article › Research › peer review