Publikationen
- 2007
Mutational analysis reveals that all tailoring region genes are required for production of polyketide antibiotic mupirocin by Pseudomonas fluorescens: Pseudomonic acid B biosynthesis precedes pseudomonic acid A
Hothersall, J., Wu, J., Rahman, A. S., Shields, J. A., Haddock, J., Johnson, N., Cooper, S. M., Stephens, E. R., Cox, R. J., Crosby, J., Willis, C. L., Simpson, T. J. & Thomas, C. M., 25 Mai 2007, in: Journal of Biological Chemistry. 282, 21, S. 15451-15461 11 S.Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
An antibiotic produced by an insect-pathogenic bacterium suppresses host defenses through phenoloxidase inhibition
Eleftherianos, I., Boundy, S., Joyce, S. A., Aslam, S., Marshall, J. W., Cox, R. J., Simpson, T. J., Clarke, D. J., Ffrench-Constant, R. H. & Reynolds, S. E., 13 Feb. 2007, in: Proceedings of the National Academy of Sciences of the United States of America. 104, 7, S. 2419-2424 6 S.Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
Biosynthesis of the 2-pyridone tenellin in the insect pathogenic fungus Beauveria bassiana
Eley, K. L., Halo, L. M., Song, Z., Powles, H., Cox, R. J., Bailey, A. M., Lazarus, C. M. & Simpson, T. J., 12 Feb. 2007, in: CHEMBIOCHEM. 8, 3, S. 289-297 9 S.Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
Characterisation of 3-methylorcinaldehyde synthase (MOS) in Acremonium strictum: First observation of a reductive release mechanism during polyketide biosynthesis
Bailey, A. M., Cox, R. J., Harley, K., Lazarus, C. M., Simpson, T. J. & Skellam, E., 1 Jan. 2007, in: Chemical communications. 39, S. 4053-4055 3 S.Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
Mupirocin H, a novel metabolite resulting from mutation of the HMG-CoA synthase analogue, mupH in Pseudomonas fluorescens
Wu, J., Cooper, S. M., Cox, R. J., Crosby, J., Crump, M. P., Hothersall, J., Simpson, T. J., Thomas, C. M. & Willis, C. L., 1 Jan. 2007, in: Chemical communications. 20, S. 2040-2042 3 S.Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
Polyketides, proteins and genes in fungi: Programmed nano-machines begin to reveal their secrets
Cox, R. J., 1 Jan. 2007, in: Organic and Biomolecular Chemistry. 5, 13, S. 2010-2026 17 S.Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
Acyl palladium species in synthesis: Single-step synthesis of α,β-unsaturated ketones from acid chlorides
Cox, R. J. & Evitt, A. S., 2007, in: Organic and Biomolecular Chemistry. 5, 2, S. 229-232 4 S.Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
Synthesis of [1,2-13C2,15N]-L-homoserine and its incorporation by the PKS-NRPS system of Fusarium moniliforme into the mycotoxin fusarin C
Rees, D. O., Bushby, N., Cox, R. J., Harding, J. R., Simpson, T. J. & Willis, C. L., 2007, in: CHEMBIOCHEM. 8, 1, S. 46-50 5 S.Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
- 2006
Catalytic relationships between type I and type II iterative polyketide synthases: The Aspergillus parasiticus norsolorinic acid synthase
Ma, Y., Smith, L. H., Cox, R. J., Beltran-Alvarez, P., Arthur, C. J. & Simpson, T. J., 1 Dez. 2006, in: CHEMBIOCHEM. 7, 12, S. 1951-1958 8 S.Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
The Malonyl Transferase Activity of Type II Polyketide Synthase Acyl Carrier Proteins
Arthur, C. J., Szafranska, A. E., Long, J., Mills, J., Cox, R. J., Findlow, S. C., Simpson, T. J., Crump, M. P. & Crosby, J., 1 Juni 2006, in: Chemistry and Biology. 13, 6, S. 587-596 10 S.Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
- 2005
Design, synthesis and analysis of inhibitors of bacterial aspartate semialdehyde dehydrogenase
Cox, R. J., Gibson, J. S. & Hadfield, A. T., 1 Dez. 2005, in: CHEMBIOCHEM. 6, 12, S. 2255-2260 6 S.Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
A fragment-based approach to understanding inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase
Mercklé, L., De Andrés-Gómez, A., Dick, B., Cox, R. J. & Godfrey, C. R. A., 1 Okt. 2005, in: CHEMBIOCHEM. 6, 10, S. 1866-1874 9 S.Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
Shift to Pseudomonic Acid B Production in P. fluorescens NCIMB10586 by Mutation of Mupirocin Tailoring Genes mupO, mupU, mupV, and macpE
Cooper, S. M., Laosripaiboon, W., Rahman, A. S., Hothersall, J., El-Sayed, A. K., Winfield, C., Crosby, J., Cox, R. J., Simpson, T. J. & Thomas, C. M., 1 Juli 2005, in: Chemistry and Biology. 12, 7, S. 825-833 9 S.Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
Mupirocin W, a novel pseudomonic acid produced by targeted mutation of the mupirocin biosynthetic gene cluster
Cooper, S. M., Cox, R. J., Crosby, J., Crump, M. P., Hothersall, J., Laosripaiboon, W., Simpson, T. J. & Thomas, C. M., 7 März 2005, in: Chemical communications. 9, S. 1179-1181 3 S.Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
Room temperature palladium catalysed coupling of acyl chlorides with terminal alkynes
Cox, R. J., Ritson, D. J., Dane, T. A., Berge, J., Charmant, J. P. H. & Kantacha, A., 28 Feb. 2005, in: Chemical communications. 8, S. 1037-1039 3 S.Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
- Veröffentlicht
Cloning fungal polyketide synthase genes: The fusarin and squalestatin synthases
Cox, R., 2005, in: ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
- 2004
Rapid cloning and expression of a fungal polyketide synthase gene involved in squalestatin biosynthesis
Cox, R. J., Glod, F., Hurley, D., Lazarus, C. M., Nicholson, T. P., Rudd, B. A. M., Simpson, T. J., Wilkinson, B. & Zhang, Y., 21 Okt. 2004, in: Chemical communications. 20, S. 2260-2261 2 S.Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
Fusarin C biosynthesis in Fusarium moniliforme and Fusarium venenatum
Song, Z., Cox, R. J., Lazarus, C. M. & Simpson, T. J., 6 Sept. 2004, in: CHEMBIOCHEM. 5, 9, S. 1196-1203 8 S.Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
Indium mediated allylation of glyoxylate oxime ethers, esters and cyanoformates
Ritson, D. J., Cox, R. J. & Berge, J., 7 Juli 2004, in: Organic and Biomolecular Chemistry. 2, 13, S. 1921-1933 13 S.Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
Expression, purification and preliminary X-ray diffraction analysis of a ketoreductase from a type II polyketide synthase
Teartasin, W., Limpkin, C., Glod, F., Spencer, J., Cox, R. J., Simpson, T. J., Crosby, J., Crump, M. P. & Hadfield, A. T., 1 Juni 2004, in: Acta Crystallographica Section D: Biological Crystallography. 60, 6, S. 1137-1138 2 S.Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review