Details
| Originalsprache | Englisch |
|---|---|
| Aufsatznummer | 139 |
| Seiten (von - bis) | 139 |
| Seitenumfang | 14 |
| Fachzeitschrift | Communications Biology |
| Jahrgang | 8 |
| Ausgabenummer | 1 |
| Publikationsstatus | Angenommen/Im Druck - 14 Jan. 2025 |
Abstract
Transmission of Zika virus (ZIKV) has been reported in 92 countries and the geographical spread of invasive virus-borne vectors has increased in recent years. Arboviruses naturally survive between vertebrate hosts and arthropod vectors. Transmission success requires the mosquito to feed on viraemic hosts. There is little specific understanding of factors that may promote ZIKV transmission-success. Here we show that mosquito host-seeking behaviour is impacted by viral infection of the vertebrae host and may be essential for the effective transmission of arboviruses like ZIKV. Human skin fibroblasts produce a variety of metabolites, and we show that ZIKV immediately alters gene/protein expression patterns in infected-dermal fibroblasts, altering their metabolism to increase the release of mosquito-attractive volatile organic compounds (VOCs), which improves its transmission success. We demonstrate that at the invasion stage, ZIKV differentially altered the emission of VOCs by significantly increasing or decreasing their amounts, while at the transmission stage of the virus, all VOCs are significantly increased. The findings are complemented by an extensive meta-proteome analysis. Overall, we demonstrate a multifaceted role of virus-host interaction and shed light on how arboviruses may influence the behaviour of their vectors as an evolved means of improving transmission-success.
ASJC Scopus Sachgebiete
- Medizin (insg.)
- Medizin (sonstige)
- Biochemie, Genetik und Molekularbiologie (insg.)
- Allgemeine Biochemie, Genetik und Molekularbiologie
- Agrar- und Biowissenschaften (insg.)
- Allgemeine Agrar- und Biowissenschaften
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in: Communications Biology, Jahrgang 8, Nr. 1, 139, 12.2025, S. 139.
Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
}
TY - JOUR
T1 - Zika virus modulates human fibroblasts to enhance transmission success in a controlled lab-setting
AU - Mozūraitis, Raimondas
AU - Cirksena, Karsten
AU - Raftari, Mohammad
AU - Hajkazemian, Melika
AU - Mustapha Abiodun, Musa
AU - Brahimi, Juela
AU - Radžiutė, Sandra
AU - Apšegaitė, Violeta
AU - Bernotienė, Rasa
AU - Ignatowicz, Lech
AU - Hick, Tessy
AU - Kirschning, Andreas
AU - Lenman, Annasara
AU - Gerold, Gisa
AU - Emami, S. Noushin
N1 - Publisher Copyright: © 2025. The Author(s).
PY - 2025/1/14
Y1 - 2025/1/14
N2 - Transmission of Zika virus (ZIKV) has been reported in 92 countries and the geographical spread of invasive virus-borne vectors has increased in recent years. Arboviruses naturally survive between vertebrate hosts and arthropod vectors. Transmission success requires the mosquito to feed on viraemic hosts. There is little specific understanding of factors that may promote ZIKV transmission-success. Here we show that mosquito host-seeking behaviour is impacted by viral infection of the vertebrae host and may be essential for the effective transmission of arboviruses like ZIKV. Human skin fibroblasts produce a variety of metabolites, and we show that ZIKV immediately alters gene/protein expression patterns in infected-dermal fibroblasts, altering their metabolism to increase the release of mosquito-attractive volatile organic compounds (VOCs), which improves its transmission success. We demonstrate that at the invasion stage, ZIKV differentially altered the emission of VOCs by significantly increasing or decreasing their amounts, while at the transmission stage of the virus, all VOCs are significantly increased. The findings are complemented by an extensive meta-proteome analysis. Overall, we demonstrate a multifaceted role of virus-host interaction and shed light on how arboviruses may influence the behaviour of their vectors as an evolved means of improving transmission-success.
AB - Transmission of Zika virus (ZIKV) has been reported in 92 countries and the geographical spread of invasive virus-borne vectors has increased in recent years. Arboviruses naturally survive between vertebrate hosts and arthropod vectors. Transmission success requires the mosquito to feed on viraemic hosts. There is little specific understanding of factors that may promote ZIKV transmission-success. Here we show that mosquito host-seeking behaviour is impacted by viral infection of the vertebrae host and may be essential for the effective transmission of arboviruses like ZIKV. Human skin fibroblasts produce a variety of metabolites, and we show that ZIKV immediately alters gene/protein expression patterns in infected-dermal fibroblasts, altering their metabolism to increase the release of mosquito-attractive volatile organic compounds (VOCs), which improves its transmission success. We demonstrate that at the invasion stage, ZIKV differentially altered the emission of VOCs by significantly increasing or decreasing their amounts, while at the transmission stage of the virus, all VOCs are significantly increased. The findings are complemented by an extensive meta-proteome analysis. Overall, we demonstrate a multifaceted role of virus-host interaction and shed light on how arboviruses may influence the behaviour of their vectors as an evolved means of improving transmission-success.
UR - http://www.scopus.com/inward/record.url?scp=85217623533&partnerID=8YFLogxK
U2 - 10.1038/s42003-025-07543-9
DO - 10.1038/s42003-025-07543-9
M3 - Article
C2 - 39885287
AN - SCOPUS:85217623533
VL - 8
SP - 139
JO - Communications Biology
JF - Communications Biology
IS - 1
M1 - 139
ER -