TY - JOUR

T1 - Understanding antibiotic resistance via outer membrane permeability

AU - Ghai, Ishan

AU - Ghai, Shashank

N1 - Funding Information: The publication of this article was funded by the Open Access fund of Leibniz Universität Hannover. The authors sincerely thank their research groups for their support.

PY - 2018/4/11

Y1 - 2018/4/11

N2 - Collective antibiotic drug resistance is a global threat, especially with respect to Gram-negative bacteria. The low permeability of the bacterial outer cell wall has been identified as a challenging barrier that prevents a sufficient antibiotic effect to be attained at low doses of the antibiotic. The Gram-negative bacterial cell envelope comprises an outer membrane that delimits the periplasm from the exterior milieu. The crucial mechanisms of antibiotic entry via outer membrane includes general diffusion porins (Omps) responsible for hydrophilic antibiotics and lipid-mediated pathway for hydrophobic antibiotics. The protein and lipid arrangements of the outer membrane have had a strong impact on the understanding of bacteria and their resistance to many types of antibiotics. Thus, one of the current challenges is effective interpretation at the molecular basis of the outer membrane permeability. This review attempts to develop a state of knowledge pertinent to Omps and their effective role in solute influx. Moreover, it aims toward further understanding and exploration of prospects to improve our knowledge of physicochemical limitations that direct the translocation of antibiotics via bacterial outer membrane.

AB - Collective antibiotic drug resistance is a global threat, especially with respect to Gram-negative bacteria. The low permeability of the bacterial outer cell wall has been identified as a challenging barrier that prevents a sufficient antibiotic effect to be attained at low doses of the antibiotic. The Gram-negative bacterial cell envelope comprises an outer membrane that delimits the periplasm from the exterior milieu. The crucial mechanisms of antibiotic entry via outer membrane includes general diffusion porins (Omps) responsible for hydrophilic antibiotics and lipid-mediated pathway for hydrophobic antibiotics. The protein and lipid arrangements of the outer membrane have had a strong impact on the understanding of bacteria and their resistance to many types of antibiotics. Thus, one of the current challenges is effective interpretation at the molecular basis of the outer membrane permeability. This review attempts to develop a state of knowledge pertinent to Omps and their effective role in solute influx. Moreover, it aims toward further understanding and exploration of prospects to improve our knowledge of physicochemical limitations that direct the translocation of antibiotics via bacterial outer membrane.

KW - Antibiotics

KW - Drug-resistance

KW - Gram-negative bacteria

KW - Influx

KW - Membrane permeability

KW - Outer membrane proteins

KW - Porins

UR - http://www.scopus.com/inward/record.url?scp=85046358213&partnerID=8YFLogxK

U2 - 10.2147/IDR.S156995

DO - 10.2147/IDR.S156995

M3 - Article

AN - SCOPUS:85046358213

VL - 11

SP - 523

EP - 530

JO - Infection and drug resistance

JF - Infection and drug resistance

SN - 1178-6973

ER -