Tri-substituted imidazole analogues of SB203580 as inducers for cardiomyogenesis of human embryonic stem cells

Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review

Autoren

  • Joo Leng Low
  • Gerrit Jürjens
  • Jayasree Seayad
  • Jasmine Seow
  • Sherwin Ting
  • Filip Laco
  • Shaul Reuveny
  • Steve Oh
  • Christina L.L. Chai

Externe Organisationen

  • A-STAR
  • Bioprocessing Technology Institute, Agency for Science Technology and Research
  • National University of Singapore
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Details

OriginalspracheEnglisch
Seiten (von - bis)3300-3303
Seitenumfang4
FachzeitschriftBioorganic and Medicinal Chemistry Letters
Jahrgang23
Ausgabenummer11
Frühes Online-Datum3 Apr. 2013
PublikationsstatusVeröffentlicht - 1 Juni 2013
Extern publiziertJa

Abstract

The p38α mitogen-activated protein kinase (MAPK) inhibitor SB203580 had been reported to enhance the cardiomyogenesis of human embryonic stem cells (hESCs). To investigate if tri-substituted imidazole analogues of SB203580 are equally effective inducers for cardiomyogenesis of hESCs, and if there is a correlation between p38α MAPK inhibition and cardiomyogenesis, we designed and synthesized a series of novel tri-substituted imidazoles with a range of p38α MAPK inhibitory activities. Our studies demonstrated that suitably designed analogues of SB203580 can also be inducers of cardiomyogenesis in hESCs and that cell growth is affected by changes in the imidazole structures.

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Tri-substituted imidazole analogues of SB203580 as inducers for cardiomyogenesis of human embryonic stem cells. / Low, Joo Leng; Jürjens, Gerrit; Seayad, Jayasree et al.
in: Bioorganic and Medicinal Chemistry Letters, Jahrgang 23, Nr. 11, 01.06.2013, S. 3300-3303.

Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review

Low, JL, Jürjens, G, Seayad, J, Seow, J, Ting, S, Laco, F, Reuveny, S, Oh, S & Chai, CLL 2013, 'Tri-substituted imidazole analogues of SB203580 as inducers for cardiomyogenesis of human embryonic stem cells', Bioorganic and Medicinal Chemistry Letters, Jg. 23, Nr. 11, S. 3300-3303. https://doi.org/10.1016/j.bmcl.2013.03.103
Low, J. L., Jürjens, G., Seayad, J., Seow, J., Ting, S., Laco, F., Reuveny, S., Oh, S., & Chai, C. L. L. (2013). Tri-substituted imidazole analogues of SB203580 as inducers for cardiomyogenesis of human embryonic stem cells. Bioorganic and Medicinal Chemistry Letters, 23(11), 3300-3303. https://doi.org/10.1016/j.bmcl.2013.03.103
Low JL, Jürjens G, Seayad J, Seow J, Ting S, Laco F et al. Tri-substituted imidazole analogues of SB203580 as inducers for cardiomyogenesis of human embryonic stem cells. Bioorganic and Medicinal Chemistry Letters. 2013 Jun 1;23(11):3300-3303. Epub 2013 Apr 3. doi: 10.1016/j.bmcl.2013.03.103
Low, Joo Leng ; Jürjens, Gerrit ; Seayad, Jayasree et al. / Tri-substituted imidazole analogues of SB203580 as inducers for cardiomyogenesis of human embryonic stem cells. in: Bioorganic and Medicinal Chemistry Letters. 2013 ; Jahrgang 23, Nr. 11. S. 3300-3303.
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T1 - Tri-substituted imidazole analogues of SB203580 as inducers for cardiomyogenesis of human embryonic stem cells

AU - Low, Joo Leng

AU - Jürjens, Gerrit

AU - Seayad, Jayasree

AU - Seow, Jasmine

AU - Ting, Sherwin

AU - Laco, Filip

AU - Reuveny, Shaul

AU - Oh, Steve

AU - Chai, Christina L.L.

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