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Trend tests for dichotomous endpoints with application to carcinogenicity studies

Publikation: Beitrag in FachzeitschriftArtikelForschungPeer-Review

Autoren

  • Markus Neuhäuser
  • Ludwig A. Hothorn

Organisationseinheiten

Externe Organisationen

  • SOLVAY GmbH

Details

OriginalspracheEnglisch
Seiten (von - bis)463-469
Seitenumfang7
FachzeitschriftTherapeutic Innovation & Regulatory Science
Jahrgang31
Ausgabenummer2
PublikationsstatusVeröffentlicht - 30 Dez. 1997

Abstract

A trend test for dichotomous endpoints analogous to the nonparametric Jonckheere test is developed. The power of this and all other single trend tests for dichotomous endpoints strongly depends on the shape of the dose response curve. Combined tests which have a stable power over a wide range of the ordered alternative are suggested. One can combine several contrast tests to a so-called adjustive test which is more powerful than a Cochran-Armitage test with equally-spaced scores. The latter was recommended by Armitage (1) in case there is no a priori knowledge of the type of the trend.

ASJC Scopus Sachgebiete

Ziele für nachhaltige Entwicklung

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Trend tests for dichotomous endpoints with application to carcinogenicity studies. / Neuhäuser, Markus; Hothorn, Ludwig A.
in: Therapeutic Innovation & Regulatory Science, Jahrgang 31, Nr. 2, 30.12.1997, S. 463-469.

Publikation: Beitrag in FachzeitschriftArtikelForschungPeer-Review

Neuhäuser M, Hothorn LA. Trend tests for dichotomous endpoints with application to carcinogenicity studies. Therapeutic Innovation & Regulatory Science. 1997 Dez 30;31(2):463-469. doi: 10.1177/009286159703100217, 10.15488/3057
Neuhäuser, Markus ; Hothorn, Ludwig A. / Trend tests for dichotomous endpoints with application to carcinogenicity studies. in: Therapeutic Innovation & Regulatory Science. 1997 ; Jahrgang 31, Nr. 2. S. 463-469.
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