Details
| Titel in Übersetzung | Totalsynthese von Thuggacin B |
|---|---|
| Originalsprache | Englisch |
| Seiten (von - bis) | 9134-9137 |
| Seitenumfang | 4 |
| Fachzeitschrift | Angewandte Chemie |
| Jahrgang | 47 |
| Ausgabenummer | 47 |
| Publikationsstatus | Veröffentlicht - 5 Nov. 2008 |
Abstract
Final proof of the complete structures of thuggacins A-C was gained by a highly convergent and flexible total synthesis. Notable features include a substrate-controlled, titanium-mediated aldol reaction, a cross-metathesis approach for converting terminal alkenes into the corresponding vinyl iodides, and the cross-coupling of a complex vinyl iodide and terminal alkyne in the Sonogashira reaction. (Chemical Equation Presented).
ASJC Scopus Sachgebiete
- Chemische Verfahrenstechnik (insg.)
- Katalyse
- Chemie (insg.)
- Allgemeine Chemie
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in: Angewandte Chemie , Jahrgang 47, Nr. 47, 05.11.2008, S. 9134-9137.
Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
}
TY - JOUR
T1 - Total synthesis of thuggacin B
AU - Bock, Martin
AU - Dehn, Richard
AU - Kirschning, Andreas
PY - 2008/11/5
Y1 - 2008/11/5
N2 - Final proof of the complete structures of thuggacins A-C was gained by a highly convergent and flexible total synthesis. Notable features include a substrate-controlled, titanium-mediated aldol reaction, a cross-metathesis approach for converting terminal alkenes into the corresponding vinyl iodides, and the cross-coupling of a complex vinyl iodide and terminal alkyne in the Sonogashira reaction. (Chemical Equation Presented).
AB - Final proof of the complete structures of thuggacins A-C was gained by a highly convergent and flexible total synthesis. Notable features include a substrate-controlled, titanium-mediated aldol reaction, a cross-metathesis approach for converting terminal alkenes into the corresponding vinyl iodides, and the cross-coupling of a complex vinyl iodide and terminal alkyne in the Sonogashira reaction. (Chemical Equation Presented).
KW - Aldol reaction
KW - Antibiotics
KW - Sonogashira reaction
KW - Total synthesis
KW - Tuberculosis
UR - http://www.scopus.com/inward/record.url?scp=56249137235&partnerID=8YFLogxK
U2 - 10.1002/anie.200803271
DO - 10.1002/anie.200803271
M3 - Article
C2 - 18925593
AN - SCOPUS:56249137235
VL - 47
SP - 9134
EP - 9137
JO - Angewandte Chemie
JF - Angewandte Chemie
SN - 1433-7851
IS - 47
ER -