Details
| Originalsprache | Englisch |
|---|---|
| Seiten (von - bis) | 3107-3109 |
| Seitenumfang | 3 |
| Fachzeitschrift | Organic letters |
| Jahrgang | 3 |
| Ausgabenummer | 20 |
| Publikationsstatus | Veröffentlicht - 4 Okt. 2001 |
Abstract
(equation presented) The enantioselective synthesis of callystatin A is descrided. The pivotal step in the synthesis is the stereoselective aldol reaction that generates the β-hydroxy ketone moiety. Utilizing the allylic strain within the ethyl ketone precursor, we were able to generate the all-syn configuration of callystatin A. For the construction of the two diene moieties, both a Heck coupling and a Wittig reaction were employed.
ASJC Scopus Sachgebiete
- Biochemie, Genetik und Molekularbiologie (insg.)
- Biochemie
- Chemie (insg.)
- Physikalische und Theoretische Chemie
- Chemie (insg.)
- Organische Chemie
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in: Organic letters, Jahrgang 3, Nr. 20, 04.10.2001, S. 3107-3109.
Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
}
TY - JOUR
T1 - Total synthesis of (-)-callystatin A
AU - Kalesse, Markus
AU - Quitschalle, Monika
AU - Khandavalli, Chary P.
AU - Saeed, Aamer
PY - 2001/10/4
Y1 - 2001/10/4
N2 - (equation presented) The enantioselective synthesis of callystatin A is descrided. The pivotal step in the synthesis is the stereoselective aldol reaction that generates the β-hydroxy ketone moiety. Utilizing the allylic strain within the ethyl ketone precursor, we were able to generate the all-syn configuration of callystatin A. For the construction of the two diene moieties, both a Heck coupling and a Wittig reaction were employed.
AB - (equation presented) The enantioselective synthesis of callystatin A is descrided. The pivotal step in the synthesis is the stereoselective aldol reaction that generates the β-hydroxy ketone moiety. Utilizing the allylic strain within the ethyl ketone precursor, we were able to generate the all-syn configuration of callystatin A. For the construction of the two diene moieties, both a Heck coupling and a Wittig reaction were employed.
UR - http://www.scopus.com/inward/record.url?scp=0035807580&partnerID=8YFLogxK
U2 - 10.1021/ol016365l
DO - 10.1021/ol016365l
M3 - Article
C2 - 11574006
AN - SCOPUS:0035807580
VL - 3
SP - 3107
EP - 3109
JO - Organic letters
JF - Organic letters
SN - 1523-7060
IS - 20
ER -