Details
| Originalsprache | Englisch |
|---|---|
| Seiten (von - bis) | 6938-6942 |
| Seitenumfang | 5 |
| Fachzeitschrift | Angewandte Chemie |
| Jahrgang | 60 |
| Ausgabenummer | 13 |
| Frühes Online-Datum | 15 Jan. 2021 |
| Publikationsstatus | Veröffentlicht - 22 März 2021 |
Abstract
The first total synthesis of chondrochloren A is accomplished using a 1,2-metallate rearrangement addition as an alternative for the Nozaki-Hiyama-Kishi reaction. This transformation also avoids the inherent challenges of this polyketide segment and provides a new, unprecedented strategy to assemble polyketidal frameworks. The formation of the Z-enamide is accomplished using a Z-selective cross coupling of the corresponding amide to a Z-vinyl bromide.
ASJC Scopus Sachgebiete
- Chemische Verfahrenstechnik (insg.)
- Katalyse
- Chemie (insg.)
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in: Angewandte Chemie , Jahrgang 60, Nr. 13, 22.03.2021, S. 6938-6942.
Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
}
TY - JOUR
T1 - The Total Synthesis of Chondrochloren A
AU - Linne, Yannick
AU - Bonandi, Elisa
AU - Tabet, Christopher
AU - Geldsetzer, Jan
AU - Kalesse, Markus
PY - 2021/3/22
Y1 - 2021/3/22
N2 - The first total synthesis of chondrochloren A is accomplished using a 1,2-metallate rearrangement addition as an alternative for the Nozaki-Hiyama-Kishi reaction. This transformation also avoids the inherent challenges of this polyketide segment and provides a new, unprecedented strategy to assemble polyketidal frameworks. The formation of the Z-enamide is accomplished using a Z-selective cross coupling of the corresponding amide to a Z-vinyl bromide.
AB - The first total synthesis of chondrochloren A is accomplished using a 1,2-metallate rearrangement addition as an alternative for the Nozaki-Hiyama-Kishi reaction. This transformation also avoids the inherent challenges of this polyketide segment and provides a new, unprecedented strategy to assemble polyketidal frameworks. The formation of the Z-enamide is accomplished using a Z-selective cross coupling of the corresponding amide to a Z-vinyl bromide.
KW - 1,2-metallate rearrangement
KW - chondrochloren
KW - Hoppe anion
KW - natural product synthesis
KW - polyketides
UR - http://www.scopus.com/inward/record.url?scp=85101587803&partnerID=8YFLogxK
U2 - 10.1002/anie.202016072
DO - 10.1002/anie.202016072
M3 - Article
C2 - 33450788
AN - SCOPUS:85101587803
VL - 60
SP - 6938
EP - 6942
JO - Angewandte Chemie
JF - Angewandte Chemie
SN - 1433-7851
IS - 13
ER -