TY - JOUR

T1 - The life of plant mitochondrial complex I

AU - Braun, Hans Peter

AU - Binder, Stefan

AU - Brennicke, Axel

AU - Eubel, Holger

AU - Fernie, Alisdair R.

AU - Finkemeier, Iris

AU - Klodmann, Jennifer

AU - König, Ann Christine

AU - Kühn, Kristina

AU - Meyer, Etienne

AU - Obata, Toshihiro

AU - Schwarzländer, Markus

AU - Takenaka, Mizuki

AU - Zehrmann, Anja

N1 - Funding information: This article summarizes contributions related to plant mitochondrial complex I presented at the 8th International Conference on Plant Mitochondrial Biology (ICPMB) which was held from May 12 to 16, 2013 in Rosario, Argentina. The authors wish to thank the organizing committee for arranging a wonderful conference. Furthermore, the authors thank the Center for Advanced Studies (CAS) of the Ludwig-Maximilians-University Munich for supporting the Symposium “The life of plant mitochondrial complex I” held in Munich on November 4/5, 2013. We thank Christine Schikowsky, Leibniz University Hannover/Germany, for the artwork of the article. Our research is supported by the Deutsche Forschungsgemeinschaft (grants BR1829-10/2 [HPB], BR326-11/1 [AB], FE552-9/2 [ARF], IF1655-1/1 [IF], SCHW 1719-1/1 [MS], TA624-2/2 [MT] and TA624-4/1 [MT]).

PY - 2014/2/21

Y1 - 2014/2/21

N2 - The mitochondrial NADH dehydrogenase complex (complex I) of the respiratory chain has several remarkable features in plants: (i) particularly many of its subunits are encoded by the mitochondrial genome, (ii) its mitochondrial transcripts undergo extensive maturation processes (e.g. RNA editing, trans-splicing), (iii) its assembly follows unique routes, (iv) it includes an additional functional domain which contains carbonic anhydrases and (v) it is, indirectly, involved in photosynthesis. Comprising about 50 distinct protein subunits, complex I of plants is very large. However, an even larger number of proteins are required to synthesize these subunits and assemble the enzyme complex. This review aims to follow the complete "life cycle" of plant complex I from various molecular perspectives. We provide arguments that complex I represents an ideal model system for studying the interplay of respiration and photosynthesis, the cooperation of mitochondria and the nucleus during organelle biogenesis and the evolution of the mitochondrial oxidative phosphorylation system.

AB - The mitochondrial NADH dehydrogenase complex (complex I) of the respiratory chain has several remarkable features in plants: (i) particularly many of its subunits are encoded by the mitochondrial genome, (ii) its mitochondrial transcripts undergo extensive maturation processes (e.g. RNA editing, trans-splicing), (iii) its assembly follows unique routes, (iv) it includes an additional functional domain which contains carbonic anhydrases and (v) it is, indirectly, involved in photosynthesis. Comprising about 50 distinct protein subunits, complex I of plants is very large. However, an even larger number of proteins are required to synthesize these subunits and assemble the enzyme complex. This review aims to follow the complete "life cycle" of plant complex I from various molecular perspectives. We provide arguments that complex I represents an ideal model system for studying the interplay of respiration and photosynthesis, the cooperation of mitochondria and the nucleus during organelle biogenesis and the evolution of the mitochondrial oxidative phosphorylation system.

KW - Carbonic anhydrase

KW - Oxidative phosphorylation

KW - Oxidoreductase

KW - Plant mitochondria

KW - Reactive oxygen species

KW - RNA editing

UR - http://www.scopus.com/inward/record.url?scp=84914170647&partnerID=8YFLogxK

U2 - 10.15488/11656

DO - 10.15488/11656

M3 - Article

C2 - 24561573

AN - SCOPUS:84914170647

VL - 19

SP - 295

EP - 313

JO - MITOCHONDRION

JF - MITOCHONDRION

SN - 1567-7249

IS - PB

ER -