Details
| Originalsprache | Englisch |
|---|---|
| Seiten (von - bis) | 1523-1543 |
| Seitenumfang | 21 |
| Fachzeitschrift | Comptes Rendus Chimie (Print) |
| Jahrgang | 11 |
| Ausgabenummer | 11-12 |
| Publikationsstatus | Veröffentlicht - 5 Sept. 2008 |
Abstract
Maytansine (1) and its congeners have been isolated from higher plants, mosses and from an Actinomycete, Actinosynnema pretiosum. The ansamitocins P-1 to P-4 (11b-11e) are structurally closely related macrolactam antibiotics which have been obtained from bacterial sources, mainly A. pretiosum. Many of these compounds are antitumor agents of extraordinary potency. Detailed structure-activity relationship (SAR) studies have been hampered by the accessibility of analogues in sufficient amounts. The present review focuses on several synthetic approaches towards the maytansinoids which include total synthesis, semisynthesis and mutational biosynthesis utilising genetically engineered microorganisms.
ASJC Scopus Sachgebiete
- Chemie (insg.)
- Allgemeine Chemie
- Chemische Verfahrenstechnik (insg.)
- Allgemeine chemische Verfahrenstechnik
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in: Comptes Rendus Chimie (Print), Jahrgang 11, Nr. 11-12, 05.09.2008, S. 1523-1543.
Publikation: Beitrag in Fachzeitschrift › Survey Paper › Forschung › Peer-Review
}
TY - JOUR
T1 - The chemistry and biology of the maytansinoid antitumor agents
AU - Kirschning, Andreas
AU - Harmrolfs, Kirsten
AU - Knobloch, Tobias
PY - 2008/9/5
Y1 - 2008/9/5
N2 - Maytansine (1) and its congeners have been isolated from higher plants, mosses and from an Actinomycete, Actinosynnema pretiosum. The ansamitocins P-1 to P-4 (11b-11e) are structurally closely related macrolactam antibiotics which have been obtained from bacterial sources, mainly A. pretiosum. Many of these compounds are antitumor agents of extraordinary potency. Detailed structure-activity relationship (SAR) studies have been hampered by the accessibility of analogues in sufficient amounts. The present review focuses on several synthetic approaches towards the maytansinoids which include total synthesis, semisynthesis and mutational biosynthesis utilising genetically engineered microorganisms.
AB - Maytansine (1) and its congeners have been isolated from higher plants, mosses and from an Actinomycete, Actinosynnema pretiosum. The ansamitocins P-1 to P-4 (11b-11e) are structurally closely related macrolactam antibiotics which have been obtained from bacterial sources, mainly A. pretiosum. Many of these compounds are antitumor agents of extraordinary potency. Detailed structure-activity relationship (SAR) studies have been hampered by the accessibility of analogues in sufficient amounts. The present review focuses on several synthetic approaches towards the maytansinoids which include total synthesis, semisynthesis and mutational biosynthesis utilising genetically engineered microorganisms.
KW - Antibiotics
KW - Maytansinoids
KW - Mutational biosynthesis
KW - Natural products
KW - Semisynthesis
KW - Total synthesis
UR - http://www.scopus.com/inward/record.url?scp=57049092389&partnerID=8YFLogxK
U2 - 10.1016/j.crci.2008.02.006
DO - 10.1016/j.crci.2008.02.006
M3 - Survey paper
AN - SCOPUS:57049092389
VL - 11
SP - 1523
EP - 1543
JO - Comptes Rendus Chimie (Print)
JF - Comptes Rendus Chimie (Print)
SN - 1631-0748
IS - 11-12
ER -