The biosynthesis and catabolism of the maleic anhydride moiety of stipitatonic acid

Publikation: Beitrag in FachzeitschriftArtikelForschungPeer-Review

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  • University of Bristol
  • National Research Center, Cairo
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OriginalspracheEnglisch
Seiten (von - bis)7519-7523
Seitenumfang5
FachzeitschriftAngewandte Chemie
Jahrgang53
Ausgabenummer29
PublikationsstatusVeröffentlicht - 14 Juli 2014

Abstract

A series of directed knockout experiments, combined with an in vitro assay of pathway components, has elucidated for the first time the chemical steps involved in the biosynthesis of the tropolone class of fungal maleic anhydrides. The pathway involves the stepwise oxidation of aldehyde and methyl carbon atoms to form a 1,2-dicarboxylate. A hydrolase-catalyzed interconversion of this and the corresponding maleic anhydride, followed by decarboxylation of the diacid leads to the pathway's final product of stipitatic acid.

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The biosynthesis and catabolism of the maleic anhydride moiety of stipitatonic acid. / Al Fahad, Ahmed; Abood, Amira; Simpson, Thomas J. et al.
in: Angewandte Chemie , Jahrgang 53, Nr. 29, 14.07.2014, S. 7519-7523.

Publikation: Beitrag in FachzeitschriftArtikelForschungPeer-Review

Al Fahad A, Abood A, Simpson TJ, Cox RJ. The biosynthesis and catabolism of the maleic anhydride moiety of stipitatonic acid. Angewandte Chemie . 2014 Jul 14;53(29):7519-7523. doi: 10.1002/anie.201403450, 10.1002/ange.201403450
Al Fahad, Ahmed ; Abood, Amira ; Simpson, Thomas J. et al. / The biosynthesis and catabolism of the maleic anhydride moiety of stipitatonic acid. in: Angewandte Chemie . 2014 ; Jahrgang 53, Nr. 29. S. 7519-7523.
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